Results 61 to 70 of about 18,213,481 (205)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Changes in levels of cartilage oligomeric proteinase and urinary C-terminal telopeptide of type II collagen in subjects with knee osteoarthritis after dextrose prolotherapy: A randomized controlled trial

Journal of Rehabilitation Medicine, 2021
Objective: To assess the effects of dextrose prolotherapy in patients with knee osteoarthritis on the levels of serum cartilage oligomeric proteinase and urinary C-terminal telopeptide of type II collagen, and on the Western Ontario McMaster Universities
Yose Waluyo, Budu, Agussalim Bukhari, Endy Adnan, Ratna Darjanti Haryadi, Irfan Idris, Firdaus Hamid, Andry Usman, Muhammad Phetrus Johan, Andi Alfian Zainuddin   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A case of proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) positive/IgG4-related lung disease

Respiratory Medicine Case Reports, 2017
IgG4-related lung disease (IgG4-RLD) is a rare and chronic progressive autoimmune disease. We report a case of IgG4-related inflammatory pseudo-tumor of the lung that was seropositive for proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA). A 61-
Hirokazu Touge, Katsuyuki Tomita, Akira Yamasaki, Eiji Shimizu   +3 more
doaj   +1 more source

Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis? [PDF]

, 2020
Aim. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in
Oya Türkollu, Gül Atilla, Necil Kütükçüler, Elif Azarsjz, Gülnur Emingil   +4 more
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Proteinase 3 activity as a biomarker for disease severity in Chronic Obstructive Pulmonary Disease [PDF]

, 2022
Background Alpha-1 antitrypsin (AAT) deficiency (AATD) represents a subset of chronic obstructive pulmonary disease (COPD) which is a progressive, inflammatory disease of the lungs.
Crisford, Helena Anne
core   +3 more sources

Determination of proteinase 3—α1-antitrypsin complexes in inflammatory fluids [PDF]

, 1992
Physiological inhibitors were tested for their in vitro interaction with neutrophil proteinase 3 (PR3). The major plasma proteinase inhibitor of PR3 is α1AT.
Hack, C. E., Kam, Chih-Min, Roel Goldschmeding, Bart A. van de Wiel, C.Erik Hack, van de Wiel, Bart A., Abbink, J. J., Powers, J. C., Chih-Min Kam, von dem Borne, A. E., Arnoud Sonnenberg, James C. Powers, Sonnenberg, A., Goldschmeding, R., Goldschmeding, Roel, Koert M. Dolman, Jannie J. Abbink, van de Wiel, B. A., Kam, C. M., Abbink, Jannie J., Albert E.G.Kr. von dem Borne, Dolman, Koert M., Powers, James C., von dem Borne, Albert E.G.Kr., Dolman, K. M., Hack, C.Erik, Sonnenberg, Arnoud   +26 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Antineutrophil cytoplasmic antibody profiles differ according to type of primary sclerosing cholangitis and autoimmune hepatitis [PDF]

Clinics
OBJECTIVES: To determine the frequency of the antineutrophil cytoplasmic antibodies (ANCA), antiproteinase-3 and antimyeloperoxidase, in primary sclerosing cholangitis (PSC) with or without inflammatory bowel disease (IBD+ or IBD-) and in different types
Juliana Goldbaum Crescente, Alessandra Dellavance, Marcio Augusto Diniz, Flair Jose Carrilho, Luis Eduardo Coelho de Andrade, Eduardo Luiz Rachid Cançado   +5 more
doaj   +2 more sources