Results 171 to 180 of about 84,285 (265)

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Growth Plate Morphogens as Potential Modulators of Cellular Tissue Remodeling by Annulus Fibrosus Cells. [PDF]

JOR Spine
Stradovnik-Poikilidis K, Teunissen M, Riemers FM, van Doeselaar M, Foolen J, Abinzano F, Tryfonidou MA, Callens SJP, Ito K.   +8 more
europepmc   +1 more source

Early Synovial Regulatory T Cell Engagement in Posttraumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early postinjury biologic processes within the synovium shape disease trajectories. We investigated whether synovial Treg cells are engaged during the early phase following joint injury and whether experimental enrichment of this ...
Xueyou Zhang, Mingde Cao, Jianting Li, Bruma Sai‐Chuen Fu, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung   +5 more
wiley   +1 more source

Ameliorative effect of Gastrodia elata Blume extract on inflammation in a rat model of osteoarthritis. [PDF]

Lab Anim Res
Lee YS, Jung DE, Seo JW, Na HJ, Park JS, Hong JW, Lee HJ, Shin JH.   +7 more
europepmc   +1 more source

MDL‐800–Induced Sirtuin 6 Activation Decreases Age‐Associated Osteoarthritis in Mice

Arthritis &Rheumatology, EarlyView.
Objective Sirtuin 6 (SIRT6) is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of MDL‐800, a small molecule activator of SIRT6, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Fragile skin may benefit from decoration. [PDF]

Mol Ther Adv
Järvinen TAH, Liao Y.
europepmc   +1 more source

Arthroscopic Marrow‐Stimulating Procedure for Full‐Thickness Knee Cartilage Lesions

Arthroscopy Techniques, EarlyView.
Abstract Articular cartilage defects remain challenging to treat because cartilage is avascular, sparsely cellular and has limited intrinsic healing potential. If left untreated, these lesions may progress to degenerative osteoarthritis, resulting in persistent pain and functional limitation.
Jyothiprasanth M., Jithin C. R., Rahul Subramaniam P. S., Akhil K. Thomas, Aghosh M. C.   +4 more
wiley   +1 more source

Introduction to the Special Issue on Proteoglycan and Glycosaminoglycan Biology. [PDF]

Proteoglycan Res
Park PW, Wang L.
europepmc   +1 more source

Biological Augmentation of Arthroscopic Partial‐Thickness Bursal‐Sided Rotator Cuff Repair Using Minced Autologous Glenohumeral Ligament Tissue Particles

Arthroscopy Techniques, EarlyView.
Abstract Rotator cuff tears are associated with high retear rates and limited healing capacity after repair. We describe an arthroscopic biological augmentation technique using minced autologous glenohumeral ligament tissue during double‐row partial‐thickness bursal‐sided rotator cuff repair.
Hengzhi Liu, Xinji Wang, Huajie Mao, Weiliang Shen   +3 more
wiley   +1 more source

<i>In Vivo</i> comparative evaluation of early- and late-stage ACLT-hMnX rat models: a case study of avidin as a cartilage-penetrating nanocarrier for disease-modifying osteoarthritis drugs. [PDF]

Front Pharmacol
Morici L, Allémann E, Jordan O.
europepmc   +1 more source