Results 261 to 270 of about 76,619 (310)
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Experientia, 1993
In this review the structure and functions of two non-related proteoglycan families are discussed. One family represents a group of extracellular matrix macromolecules characterized by core proteins with leucine-rich repeat motifs. Within this family special attention is given to those members which carry chondroitin or dermatan sulfate ...
H, Kresse, H, Hausser, E, Schönherr
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In this review the structure and functions of two non-related proteoglycan families are discussed. One family represents a group of extracellular matrix macromolecules characterized by core proteins with leucine-rich repeat motifs. Within this family special attention is given to those members which carry chondroitin or dermatan sulfate ...
H, Kresse, H, Hausser, E, Schönherr
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Proteoglycans in Dentinogenesis
Critical Reviews in Oral Biology & Medicine, 2001The predominant proteoglycans present in predentin and dentin are the chondroitin-sulphate-rich decorin and biglycan and the keratan-sulphate-rich lumican and fibromodulin. These are small, interstitial, leucine-rich proteoglycans which have recently been shown to exist in gradients across the predentin.
G, Embery +4 more
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Proteoglycans in amyloidogenesis
Neurobiology of Aging, 1989The potentially important role of proteoglycans and glycosaminoglycans in the modern concept of general amyloidogenesis has been discussed.
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Cornea, 2002
Various proteoglycans are expressed in ocular tissues. We investigated and reviewed the distribution and the potential roles of proteoglycans in cornea, trabecular meshwork, and retinal tissues.Immunohistochemical studies were performed in rat ocular tissues. The concentration of transforming growth factor (TGF)-beta2, which regulates the expression of
Hidenobu, Tanihara +4 more
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Various proteoglycans are expressed in ocular tissues. We investigated and reviewed the distribution and the potential roles of proteoglycans in cornea, trabecular meshwork, and retinal tissues.Immunohistochemical studies were performed in rat ocular tissues. The concentration of transforming growth factor (TGF)-beta2, which regulates the expression of
Hidenobu, Tanihara +4 more
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Current Pharmaceutical Design, 2017
Most proteoglycans are heterogeneous molecules composed of a protein core with glycosaminoglycans (GAGs) attached. GAGs are highly negatively charged molecules that readily bind to enzymes, growth factors, cytokines etc. and as such have many functions.
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Most proteoglycans are heterogeneous molecules composed of a protein core with glycosaminoglycans (GAGs) attached. GAGs are highly negatively charged molecules that readily bind to enzymes, growth factors, cytokines etc. and as such have many functions.
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1994
Cytokines play an important regulatory role in the metabolism of proteoglycans. Proteoglycans are found in plasma membranes, but predominantly in the extra-cellular matrix. In the latter they are quantitatively and qualitatively essential components. Especially in a tissue like cartilage without any blood vessels, the cells are dependent on cytokines ...
J J, Nietfeld +2 more
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Cytokines play an important regulatory role in the metabolism of proteoglycans. Proteoglycans are found in plasma membranes, but predominantly in the extra-cellular matrix. In the latter they are quantitatively and qualitatively essential components. Especially in a tissue like cartilage without any blood vessels, the cells are dependent on cytokines ...
J J, Nietfeld +2 more
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Radioimmunoassay of Proteoglycans
Journal of Immunoassay, 1984Human articular cartilage proteoglycan monomers (PG) were purified and used for developing a radioimmunoassay. Its analytical sensitivity is 0.6 ng/tube and its clinical sensitivity is 20 microliter/tube for serum and 0.12 microliter/tube for synovial fluid.
P, Gysen, P, Franchimont
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Bulletin of Experimental Biology and Medicine, 1996
Studies of proteoglycans for their capacity to perform the function of steric exclusion of cells are reviewed. The ability of the proteoglycans hyaluronic acid and protein-chrondroitinkeratosulfate and their aggregates to effect cell aggregation and steric exclusion is determined by the structure of glycosaminoglycan components and the amount of ...
S M, Bychkov, S A, Kuz'mina
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Studies of proteoglycans for their capacity to perform the function of steric exclusion of cells are reviewed. The ability of the proteoglycans hyaluronic acid and protein-chrondroitinkeratosulfate and their aggregates to effect cell aggregation and steric exclusion is determined by the structure of glycosaminoglycan components and the amount of ...
S M, Bychkov, S A, Kuz'mina
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Interaction of bone proteoglycans and proteoglycan components with hydroxyapatite
Biochimica et Biophysica Acta (BBA) - General Subjects, 2001The small leucine-rich proteoglycans (SLRPs) of bone interact with hydroxyapatite (HAP) and are proposed to play an important role in the regulation of the mineralisation process. The present study has examined the interaction of bone SLRPs, purified, liberated bone glycosaminoglycan (GAG) chains and core proteins, as well as commercial chondroitin 4 ...
S G, Rees +3 more
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Evidence of proteoglycan/proteoglycan interactions within aggregates
Journal of Orthopaedic Research, 1991AbstractNonaggregated proteoglycan monomers, digested fragments of the monomers, as well as link proteins have been shown to self‐associate. These associations have not been shown to occur on the aggregate. However, previous reports, using the Kleinschmidt technique of monolayer electron microscopy, have noted proteoglycan subunits on the aggregate ...
A, Kahn +3 more
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