Results 11 to 20 of about 391,640 (387)
The model of proteolysis [PDF]
Nature Precedings, 2010 AbstractThis document presents the original approach for estimating parameters of proteolysis process. Data used to fit the model are taken from massspectrometric experiments. For parameters estimation the Levenberg-Marquadt algorithm is used. The motivation for model is a hypothesisthat discrimination between cancer patients and healthy donors can be ...
Piotr Dittwald, Anna Gambin
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Regulated Proteolysis in Bacteria. [PDF]
Annual Review of Biochemistry, 2018 Regulated proteolysis is a vital process that affects all living things. Bacteria use energy-dependent AAA+ proteases to power degradation of misfolded and native regulatory proteins.
S. Mahmoud, Peter Chien
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CHEMISTRY OF PROTEOLYSIS [PDF]
, 1946 Explanations have been put forward on the basis of the dipole moments of C—H, C—C, N-H bonds for the enzymatic breakdown of protein molecules. The observed fact that proteolysis is favoured in the vicinity of an aromatic ring, is suggested to be due to the property of this group to induce polarity in the neighbouring carbon atom.
SUDHINDRA NATH SEN
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Product inhibition in native-state proteolysis. [PDF]
PLoS ONE, 2014 The proteolysis kinetics of intact proteins by nonspecific proteases provides valuable information on transient partial unfolding of proteins under native conditions.
Joseph R Kasper +2 more
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Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies
Frontiers in Endocrinology, 2022 The physiological roles of proteolysis are not limited to degrading unnecessary proteins. Proteolysis plays pivotal roles in various biological processes through cleaving peptide bonds to activate and inactivate proteins including enzymes, transcription ...
Daiji Kiyozumi +4 more
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IUCrJ, 2020 Tannerella forsythia is an oral dysbiotic periodontopathogen involved in severe human periodontal disease. As part of its virulence factor armamentarium, at the site of colonization it secretes mirolysin, a metallopeptidase of the unicellular pappalysin ...
Tibisay Guevara +4 more
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Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy
Journal of Hematology & Oncology, 2020 Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. A bifunctional PROTAC molecule consists of a ligand (mostly small-molecule inhibitor) of the protein of interest (POI) and a covalently ...
Xin Li, Yongcheng Song
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Cells, 2021 The degradation of most intracellular proteins is a dynamic and tightly regulated process performed by proteasomes. To date, different forms of proteasomes have been identified.
Alexander Burov +14 more
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Microbiome, 2021 Background Proteolysis regulation allows gut microbes to respond rapidly to dynamic intestinal environments by fast degradation of misfolded proteins and activation of regulatory proteins.
Zhixiang Yan +11 more
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Phosphorylation Meets Proteolysis [PDF]
Structure, 2012 Phosphorylation is a reversible post-translational modification that regulates many proteins and enzymes, including proteases, as shown by two recent publications. Huang and colleagues and Velázquez-Delgado and Hardy (this issue of Structure) describe how phosphorylation activates the protease activity of the deubiquitinating enzyme DUBA and how it ...
Christopher J. Farady, Martin Renatus
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