Results 11 to 20 of about 437,752 (336)
Regulated Proteolysis in Bacteria [PDF]
Annual Review of Biochemistry, 2018 Regulated proteolysis is a vital process that affects all living things. Bacteria use energy-dependent AAA+ proteases to power degradation of misfolded and native regulatory proteins. Given that proteolysis is an irreversible event, specificity and selectivity in degrading substrates are key.
Samar A, Mahmoud, Peter, Chien
openaire +3 more sources
Proteolysis-targeting chimeras (PROTACs) in cancer therapy
Molecular Cancer, 2022 Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits target protein and E3 ubiquitin ligase together to trigger proteasomal ...
Xinyi Li +5 more
semanticscholar +1 more source
The Proteolysis of ECM in Intervertebral Disc Degeneration
International Journal of Molecular Sciences, 2022 Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs throughout the human life span and is a major cause of lower back pain. Better elucidation of the molecular mechanisms involved in disc degeneration could provide
Huaizhen Liang +5 more
semanticscholar +1 more source
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery.
Cell, 2020 New biological tools provide new techniques to probe fundamental biological processes. Here we describe the burgeoning field of proteolysis-targeting chimeras (PROTACs), which are capable of modulating protein concentrations at a post-translational level
George M. Burslem, C. Crews
semanticscholar +1 more source
Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy
Journal of Hematology & Oncology, 2020 Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. A bifunctional PROTAC molecule consists of a ligand (mostly small-molecule inhibitor) of the protein of interest (POI) and a covalently ...
Xin Li, Yongcheng Song
semanticscholar +1 more source
Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies
Frontiers in Endocrinology, 2022 The physiological roles of proteolysis are not limited to degrading unnecessary proteins. Proteolysis plays pivotal roles in various biological processes through cleaving peptide bonds to activate and inactivate proteins including enzymes, transcription ...
Daiji Kiyozumi +4 more
doaj +1 more source
Microbiome, 2021 Background Proteolysis regulation allows gut microbes to respond rapidly to dynamic intestinal environments by fast degradation of misfolded proteins and activation of regulatory proteins.
Zhixiang Yan +11 more
doaj +1 more source
Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function
Microbiology Spectrum, 2023 Many CAAX proteins, such as Ras GTPase, undergo a series of posttranslational modifications at their carboxyl terminus (i.e., cysteine prenylation, endoproteolysis of AAX, and carboxylmethylation).
Rajani Ravishankar +6 more
doaj +1 more source
Phosphorylation Meets Proteolysis [PDF]
Structure, 2012 Phosphorylation is a reversible post-translational modification that regulates many proteins and enzymes, including proteases, as shown by two recent publications. Huang and colleagues and Velázquez-Delgado and Hardy (this issue of Structure) describe how phosphorylation activates the protease activity of the deubiquitinating enzyme DUBA and how it ...
Renatus, Martin, Farady, Christopher J.
openaire +2 more sources
Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
eLife, 2020 APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55 ...
James Holder +2 more
doaj +1 more source