Results 21 to 30 of about 391,640 (387)
Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function
Microbiology Spectrum, 2023 Many CAAX proteins, such as Ras GTPase, undergo a series of posttranslational modifications at their carboxyl terminus (i.e., cysteine prenylation, endoproteolysis of AAX, and carboxylmethylation).
Rajani Ravishankar +6 more
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Nature Communications, 2020 Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the potential to prevent and treat various age-related diseases and extend healthspan.
Yonghan He +21 more
semanticscholar +1 more source
The Role of Proteolysis in Amyloidosis
International Journal of Molecular Sciences, 2022 Amyloidoses are a group of diseases associated with deposits of amyloid fibrils in different tissues. So far, 36 different types of amyloidosis are known, each due to the misfolding and accumulation of a specific protein. Amyloid deposits can be found in several organs, including the heart, brain, kidneys, and spleen, and can affect single or multiple ...
Acquasaliente L., De Filippis V.
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Nanomechanical in situ monitoring of proteolysis of peptide by Cathepsin B. [PDF]
PLoS ONE, 2009 Characterization and control of proteolysis of peptides by specific cellular protease is a priori requisite for effective drug discovery. Here, we report the nanomechanical, in situ monitoring of proteolysis of peptide chain attributed to protease ...
Taeyun Kwon +9 more
doaj +1 more source
PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics
Oncogene, 2020 Using PROteolysis TArgeting Chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has emerged as a potential therapeutic strategy for cancer. PROTACs are heterobifunctional molecules consisting of one ligand for binding to a protein
Sajid Khan +7 more
semanticscholar +1 more source
Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
eLife, 2020 APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-counteracting phosphatases PP1 and PP2A-B55 ...
James Holder +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer. One important post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylation ...
Dominique Manikowski +6 more
doaj +1 more source
European Respiratory Journal, 2003 Pulmonary emphysema is a major component of the morbidity and mortality of chronic obstructive pulmonary disease (COPD), a condition that has become the fourth leading cause of death in the USA, and is becoming epidemic worldwide. Emphysema is defined as enlargement of peripheral airspaces of the lung including respiratory bronchioles, alveolar ducts ...
openaire +3 more sources
IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin [PDF]
, 2009 Background: Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage
Brundin, Patrick +4 more
core +3 more sources
Epigenetics & Chromatin, 2023 Background Proteolysis of the histone H3 N-terminal tail (H3NT) is an evolutionarily conserved epigenomic feature of nearly all eukaryotes, generating a cleaved H3 product that is retained in ~ 5–10% of the genome.
Benjamin H. Weekley, Judd C. Rice
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