Results 31 to 40 of about 391,640 (387)
Proteolysis‐targeting chimeras in drug development: A safety perspective
British Journal of Pharmacology, 2020 Proteolysis‐targeting chimeras are a new drug modality that exploits the endogenous ubiquitin proteasome system to degrade a protein of interest for therapeutic benefit.
K. Moreau +8 more
semanticscholar +1 more source
The Role of DmCatD, a Cathepsin D-Like Peptidase, and Acid Phosphatase in the Process of Follicular Atresia in Dipetalogaster maxima (Hemiptera: Reduviidae), a Vector of Chagas' Disease [PDF]
, 2015 In this work, we have investigated the involvement of DmCatD, a cathepsin D-like peptidase, and acid phosphatase in the process of follicular atresia of Dipetalogaster maxima, a hematophagous insect vector of Chagas' disease. For the studies, fat bodies,
Canavoso, Lilian Etelvina +3 more
core +8 more sources
The regions of the sequence most exposed to the solvent within the amyloidogenic state of a protein initiate the aggregation process. [PDF]
, 2004 Formation of misfolded aggregates is an essential part of what proteins can do. The process of protein aggregation is central to many human diseases and any aggregating event needs to be prevented within a cell and in protein design.
AMORESANO, ANGELA +6 more
core +1 more source
Frontiers in Sports and Active Living, 2021 Background: It is often advised to ensure a high-protein intake during energy-restricted diets. However, it is unclear whether a high-protein intake is able to maintain muscle mass and contractility in the absence of resistance training.Materials and ...
Christian Roth +2 more
doaj +1 more source
Scientific Reports, 2018 Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 as a highly transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes angiotensin-converting enzyme 2 (ACE2) as a host protein receptor and mediates ...
R. Kirchdoerfer +9 more
semanticscholar +1 more source
Nature, 1957 IT was shown by Linderstrom-Lang and co-workers1 that the tryptic hydrolysis of β-lactoglobulin involves the reversible denaturation of the protein as a preliminary stage. A consideration of known facts, together with new evidence obtained in connexion with an investigation of the mechanism of bating of skins in leather manufacture2, indicates that ...
openaire +2 more sources
Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep [PDF]
, 2006 The aim of this study was to characterize the cerebrospinal fluid (CSF) prion protein (PrP) of healthy and naturally scrapie-affected sheep. The soluble form of CSF PrPC immunoblotted with an anti-octarepeat and an anti-C terminus mAb showed two isoforms
Andréoletti +24 more
core +3 more sources
Relationship between haptoglobin and serum amyloid A in milk and milk quality [PDF]
, 2008 The objective of this study was to evaluate relationships between the presence in milk of the major bovine acute phase proteins, haptoglobin (Hp) and serum amyloid A (SAA), and milk quality parameters.
Bach Larsen, Lotte +4 more
core +1 more source
Regulated degradation of the APC coactivator Cdc20
Cell Division, 2010 Background Cdc20 is a highly conserved activator of the anaphase-promoting complex (APC), promoting cell-cycle-regulated ubiquitination and proteolysis of a number of critical cell-cycle-regulatory targets including securin and mitotic cyclins. APC-Cdc20
Robbins Jonathan A, Cross Frederick R
doaj +1 more source
Evidence for Proline Utilization by Oral Bacterial Biofilms Grown in Saliva
Frontiers in Microbiology, 2021 Within the mouth bacteria are starved of saccharides as their main nutrient source between meals and it is unclear what drives their metabolism. Previously oral in vitro biofilms grown in saliva have shown proteolytic degradation of salivary proteins and
Leanne M. Cleaver +2 more
doaj +1 more source