Results 1 to 10 of about 538,471 (385)
Highly accurate protein structure prediction for the human proteome
Nature, 2021 Protein structures can provide invaluable information, both for reasoning about biological processes and for enabling interventions such as structure-based drug development or targeted mutagenesis.
Kathryn Tunyasuvunakool +2 more
exaly +2 more sources
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput
Nature Methods, 2019 We present an easy-to-use integrated software suite, DIA-NN, that exploits deep neural networks and new quantification and signal correction strategies for the processing of data-independent acquisition (DIA) proteomics experiments.
Vadim Demichev +2 more
exaly +2 more sources
Undulating changes in human plasma proteome profiles across the lifespan
Nature Medicine, 2019 Aging is a predominant risk factor for several chronic diseases that limit healthspan1. Mechanisms of aging are thus increasingly recognized as potential therapeutic targets.
Benoit Lehallier +2 more
exaly +2 more sources
A draft map of the human proteome
Nature, 2014 The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the
Min-Sik Kim +2 more
exaly +2 more sources
Severe childhood malaria syndromes defined by plasma proteome profiles [PDF]
, 2012 BACKGROUND Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood.
A Hodgetts +36 more
core +17 more sources
Neurobiology of Disease, 2021 Choroid plexus epithelial cells (CPEpiCs) determine the composition of cerebrospinal fluid (CSF) and constitute the blood-CSF barrier (BCSFB), functions that are altered in neurodegenerative diseases.
Alan Zanardi +5 more
doaj +1 more source
Data in Brief, 2022 In this article, we present a data dependent acquisition (DDA) dataset which was generated as a reference and ground truth quantitative dataset. While initially used to compare samples measured with DDA and data independent acquisition (DIA) (Barkovits ...
Julian Uszkoreit +6 more
doaj +1 more source
Accurate proteome-wide missense variant effect prediction with AlphaMissense
Science, 2023 The vast majority of missense variants observed in the human genome are of unknown clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on human and primate variant population frequency databases to predict missense ...
Jun Cheng +15 more
semanticscholar +1 more source
Quality Control—A Stepchild in Quantitative Proteomics: A Case Study for the Human CSF Proteome
Biomolecules, 2023 Proteomic studies using mass spectrometry (MS)-based quantification are a main approach to the discovery of new biomarkers. However, a number of analytical conditions in front and during MS data acquisition can affect the accuracy of the obtained outcome.
Svitlana Rozanova +7 more
doaj +1 more source