Identification of novel functional brain proteins for treatment-resistant schizophrenia: Based on a proteome-wide association study [PDF]
European Psychiatry, 2023 Objective Genetic approaches are increasingly advantageous in characterizing treatment-resistant schizophrenia (TRS). We aimed to identify TRS-associated functional brain proteins, providing a potential pathway for improving psychiatric classification ...
Wenming Wei +13 more
doaj +6 more sources
PWAS: proteome-wide association study—linking genes and phenotypes by functional variation in proteins [PDF]
Genome Biology, 2020 We introduce Proteome-Wide Association Study (PWAS), a new method for detecting gene-phenotype associations mediated by protein function alterations. PWAS aggregates the signal of all variants jointly affecting a protein-coding gene and assesses their ...
Nadav Brandes +2 more
doaj +6 more sources
New insights into the hypothalamic–pituitary– thyroid axis: a transcriptome- and proteome-wide association study [PDF]
European Thyroid JournalIntroduction: Thyroid hormones have systemic effects on the human body and play a key role in the development and function of virtually all tissues.
Sara Monteiro-Martins +7 more
doaj +10 more sources
Brain proteome‐wide association study linking‐genes in multiple sclerosis pathogenesis [PDF]
Annals of Clinical and Translational Neurology, 2023 Objectives To identify genes that confer MS risk via the alteration of cis‐regulated protein abundance and verify their aberrant expression in human brain.
Tingting Jia +4 more
doaj +4 more sources
Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage [PDF]
Genome Biology, 2023 Background The pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic, transcriptomic, and proteomic association studies can nominate causal determinants of kidney function and ...
Pascal Schlosser +12 more
doaj +4 more sources
A proteome-wide association study reveals novel plasma proteins as potential therapeutic targets for metabolic dysfunction-associated steatotic liver disease [PDF]
Frontiers in EndocrinologyIntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health burden with limited therapeutic options. To identify novel proteins involved in its pathogenesis and reveal potential drug targets, we performed an ...
Qian Zhong +7 more
doaj +4 more sources
Novel candidate plasma proteins for the pathogenesis and treatment of atopic dermatitis revealed by proteome-wide association study [PDF]
Scientific ReportsAtopic dermatitis (AD) is an immune-related skin disease with a genetic background. Numerous loci have been identified associated with AD to better comprehend its complicated genetic mechanisms by genome‑wide association studies (GWASs). However, current
Chen Luo +9 more
doaj +4 more sources
ICA1L Is Associated with Small Vessel Disease: A Proteome-Wide Association Study in Small Vessel Stroke and Intracerebral Haemorrhage. [PDF]
Int J Mol Sci, 2022 Small vessel strokes (SVS) and intracerebral haemorrhages (ICH) are acute outcomes of cerebral small vessel disease (SVD). Genetic studies combining both phenotypes have identified three loci associated with both traits. However, the genetic cis-regulation at the protein level associated with SVD has not been studied before.
Cullell N +11 more
europepmc +8 more sources
Plasma proteome analysis implicates novel proteins as potential therapeutic targets for chronic kidney disease: A proteome-wide association study [PDF]
HeliyonChronic kidney disease (CKD) is prevalent globally with limited therapeutic drugs available. To systemically identify novel proteins involved in the pathogenesis of CKD and possible therapeutic targets, we integrated human plasma proteomes with the ...
Yang Xiong +7 more
doaj +2 more sources
Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases [PDF]
Cardiovascular DiabetologyBackground Cardiovascular diseases (CVD) are the leading cause of global mortality, yet current treatments benefit only a subset of patients. To identify new potential treatment targets, we conducted the first proteome wide association study (PWAS) for ...
Jia-Hao Wang +14 more
doaj +2 more sources