Results 1 to 10 of about 42,373 (143)

PWAS: proteome-wide association study—linking genes and phenotypes by functional variation in proteins [PDF]

Genome Biology, 2020
We introduce Proteome-Wide Association Study (PWAS), a new method for detecting gene-phenotype associations mediated by protein function alterations. PWAS aggregates the signal of all variants jointly affecting a protein-coding gene and assesses their ...
Nadav Brandes, Nathan Linial, Michal Linial   +2 more
doaj   +6 more sources

New insights into the hypothalamic–pituitary– thyroid axis: a transcriptome- and proteome-wide association study [PDF]

European Thyroid Journal
Introduction: Thyroid hormones have systemic effects on the human body and play a key role in the development and function of virtually all tissues.
Sara Monteiro-Martins, Rosalie B T M Sterenborg, Oleg Borisov, Nora Scherer, Yurong Cheng, Marco Medici, Anna Köttgen, Alexander Teumer   +7 more
doaj   +10 more sources

Brain proteome‐wide association study linking‐genes in multiple sclerosis pathogenesis [PDF]

Annals of Clinical and Translational Neurology, 2023
Objectives To identify genes that confer MS risk via the alteration of cis‐regulated protein abundance and verify their aberrant expression in human brain.
Tingting Jia, Yanni Ma, Fengqin Qin, Feng Han, Chengcheng Zhang   +4 more
doaj   +4 more sources

Brain proteome-wide association study implicates novel proteins in depression pathogenesis. [PDF]

Nat Neurosci, 2021
Depression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated depression genome-wide association study (GWAS) results (N = 500,199) with human brain proteomes (N = 376) to perform a proteome-wide association study of depression followed by Mendelian randomization.
Wingo TS, Liu Y, Gerasimov ES, Gockley J, Logsdon BA, Duong DM, Dammer EB, Lori A, Kim PJ, Ressler KJ, Beach TG, Reiman EM, Epstein MP, De Jager PL, Lah JJ, Bennett DA, Seyfried NT, Levey AI, Wingo AP.   +18 more
europepmc   +8 more sources

Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies [PDF]

HGG Advances, 2023
Summary: Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, most ...
Daiwei Zhang, Boran Gao, Qidi Feng, Ani Manichaikul, Gina M. Peloso, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Stacey Gabriel, Namrata Gupta, Joshua D. Smith, Francois Aguet, Kristin G. Ardlie, Thomas W. Blackwell, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Laura J. Scott, Xiang Zhou, Seunggeun Lee   +21 more
doaj   +6 more sources

Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster [PDF]

Nature Communications, 2016
How genetic diversity generates complex phenotypes along a continuum remains a fundamental question of biology. Here—applying the emerging SWATH proteomics technology—the authors describe a proteome wide association study (PWAS) of Drosophila wing size ...
Hirokazu Okada, H. Alexander Ebhardt, Sibylle Chantal Vonesch, Ruedi Aebersold, Ernst Hafen   +4 more
doaj   +7 more sources

Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder. [PDF]

Genes (Basel), 2022
Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer risk of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with the PTSD GWAS dataset, respectively, to conduct a ...
Zhang Z, Meng P, Zhang H, Jia Y, Wen Y, Zhang J, Chen Y, Li C, Pan C, Cheng S, Yang X, Yao Y, Liu L, Zhang F.   +13 more
europepmc   +5 more sources

ICA1L Is Associated with Small Vessel Disease: A Proteome-Wide Association Study in Small Vessel Stroke and Intracerebral Haemorrhage. [PDF]

Int J Mol Sci, 2022
Small vessel strokes (SVS) and intracerebral haemorrhages (ICH) are acute outcomes of cerebral small vessel disease (SVD). Genetic studies combining both phenotypes have identified three loci associated with both traits. However, the genetic cis-regulation at the protein level associated with SVD has not been studied before.
Cullell N, Gallego-Fábrega C, Cárcel-Márquez J, Muiño E, Llucià-Carol L, Lledós M, Martín-Campos JM, Molina J, Casas L, Almeria M, Fernández-Cadenas I, Krupinski J.   +11 more
europepmc   +8 more sources

Identification of novel functional brain proteins for treatment-resistant schizophrenia: Based on a proteome-wide association study [PDF]

European Psychiatry, 2023
Objective Genetic approaches are increasingly advantageous in characterizing treatment-resistant schizophrenia (TRS). We aimed to identify TRS-associated functional brain proteins, providing a potential pathway for improving psychiatric classification ...
Wenming Wei, Huijie Zhang, Bolun Cheng, Xiaoyue Qin, Dan He, Na Zhang, Yijing Zhao, Qingqing Cai, Sirong Shi, Xiaoge Chu, Yan Wen, Huan Liu, Yumeng Jia, Feng Zhang   +13 more
doaj   +4 more sources

Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia. [PDF]

Am J Hum Genet
Transcriptome-wide association study (TWAS) tools have been applied to conduct proteome-wide association studies (PWASs) by integrating proteomics data with genome-wide association study (GWAS) summary data. The genetic effects of PWAS-identified significant genes are potentially mediated through genetically regulated protein abundance, thus informing ...
Hu T, Parrish RL, Dai Q, Buchman AS, Tasaki S, Bennett DA, Seyfried NT, Epstein MP, Yang J.   +8 more
europepmc   +5 more sources