Results 101 to 110 of about 115,149 (302)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics.

PLoS ONE
While genome-wide association studies (GWAS) have identified genetic variants associated with intelligence, their biological mechanisms remain largely unexplored.
Zheng Zhang, Yousong Zhu, Junlong Zhang, Wenbin He, Cheng Han   +4 more
doaj   +1 more source

Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome

Genome Medicine, 2023
Background The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) study to identify candidate protein markers and therapeutic targets for colorectal cancer (CRC).
Jing Sun, Jianhui Zhao, Fangyuan Jiang, Lijuan Wang, Qian Xiao, Fengyan Han, Jie Chen, Shuai Yuan, Jingsun Wei, Susanna C. Larsson, Honghe Zhang, Malcolm G Dunlop, Susan M Farrington, Kefeng Ding, Evropi Theodoratou, Xue Li   +15 more
doaj   +1 more source

Proteomic Analysis of Chloroplast-to-Chromoplast Transition in Tomato Reveals Metabolic Shifts Coupled with Disrupted Thylakoid Biogenesis Machinery and Elevated Energy-Production Components [PDF]

, 2012
A comparative proteomic approach was performed to identify differentially expressed proteins in plastids at three stages of tomato(Solanum lycopersicum) fruit ripening (mature-green, breaker, red). Stringent curation and processing of the data from three
Alba, Aldridge, Altschul, Andersson, Andon, Armbruster, Asano, Baginsky, Balmer, Bannai, Barry, Barsan, Benjamini, Benning, Bian, Birtić, Blanke, Booth, Botella-Pavía, Bouvier, Bouyssié, Bramley, Bräutigam, Cai, Camara, Chen, Chen, Cho, Deborde, Delmar, Delmar, Demartini, Dieterle, Egea, Egea, Emanuelsson, Emes, Fan, Faurobert, Ferro, Fischer, Harris, Heazlewood, Heazlewood, Hetherington, Huang, Issaq, Jebanathirajah, Jeong, Jimenez, Kahlau, Kato, Kato, Kleffmann, Krech, Lee, Li, Li, Liu, Liu, Liu, Ljubesić, Lopez-Juez, Lundquist, Lytovchenko, Maple, Maple, Marano, McAndrew, Millar, Moing, Neta-Sharir, Niewiadomski, Onishi, Osorio, Palma, Paoletti, Pech, Peng, Pierleoni, Pirrello, Plücken, Ren, Richly, Rocco, Rutschow, Schauer, Seigneurin-Berny, Shipman-Roston, Siddique, Simkin, Small, Smith, Spurr, Su, Sun, Suzuki, Thelen, Thimm, Thomson, Tiwari, Torgrip, van Wijk, Vitha, von Zychlinski, Waters, Yakir-Tamang, Zeng, Zhang, Zhu, Zybailov   +110 more
core   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach [PDF]

, 2017
The symptoms of malaria are brought about by blood-stage parasites, which are established when merozoites invade human erythrocytes. Our understanding of the molecular events that underpin erythrocyte invasion remains hampered by the short-period of time
Geromanos, Scott J., Haynes, J. David, Herrera, Raul, Kumar, Krishan, Moch, J. Kathleen, Nagarajan, Vijayaraj, Narum, David L., Nold, Michael J., Otto, Thomas D., Porcella, Stephen F., Rayner, Julian C., Reiter, Karine, Squires, R. Burke, Srinivasan, Prakash, Sturdevant, Dan   +14 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source