Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases [PDF]
Cardiovascular DiabetologyBackground Cardiovascular diseases (CVD) are the leading cause of global mortality, yet current treatments benefit only a subset of patients. To identify new potential treatment targets, we conducted the first proteome wide association study (PWAS) for ...
Jia-Hao Wang +14 more
doaj +4 more sources
Proteome‐Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease [PDF]
CNS Neurosci TherTo identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset and progression of Parkinson's disease (PD) through integrative proteomic and genetic analyses.
Chenhao Gao +13 more
europepmc +3 more sources
Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma [PDF]
GigasciencePancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy, largely due to the paucity of reliable biomarkers for early detection and therapeutic targeting.
Jingjing Zhu +19 more
europepmc +3 more sources
Identification and validation of ECM1 as a causal plasma biomarker in knee osteoarthritis through proteome-wide association study and bioinformatics [PDF]
Medicine (Baltimore)Knee osteoarthritis (KOA) is a degenerative joint disease with a genetic component. Nonetheless, it remains largely unknown how risk variants influence the OA risk through their effects on proteins.
Huadong Wang +3 more
europepmc +3 more sources
Identification of novel plasma proteins as potential therapeutic targets for benign prostatic hyperplasia: a proteome-wide association study [PDF]
Transl Androl UrolBackground Benign prostatic hyperplasia (BPH) represents a prevalent age-related disorder with suboptimal pharmacological management. To systematically identify plasma proteins causally linked to BPH pathogenesis and therapeutic potential, we conducted a
Xinyi Luo +5 more
europepmc +3 more sources
Brain proteome-wide association study implicates novel proteins in depression pathogenesis. [PDF]
Nat Neurosci, 2021 Depression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated depression genome-wide association study (GWAS) results (N = 500,199) with human brain proteomes (N =
Wingo TS +18 more
europepmc +2 more sources
Integrative Post-Genome-Wide Association Study Analyses Relevant to Psychiatric Disorders: Imputing Transcriptome and Proteome Signals [PDF]
Complex Psychiatry, 2023 Background: The genome-wide association study (GWAS) is a common tool to identify genetic variants associated with complex traits, including psychiatric disorders (PDs).
Hüseyin Gedik +4 more
openalex +2 more sources
Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease [PDF]
npj Parkinson's Disease, 2023 Common and rare variants in the LRRK2 locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remain unknown.
Carlos Cruchaga +25 more
semanticscholar +4 more sources
Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage [PDF]
Genome Biology, 2023 Background The pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic, transcriptomic, and proteomic association studies can nominate causal determinants of kidney function and ...
Pascal Schlosser +12 more
doaj +2 more sources
Omnibus proteome-wide association study (PWAS-O) identified 43 risk genes for Alzheimer’s disease dementia [PDF]
medRxiv, 2022 Proteome-wide association study (PWAS) integrating proteomics data with GWAS summary data is a powerful tool to identify risk genes for complex diseases.
Tingyang Hu +8 more
openalex +2 more sources