Results 11 to 20 of about 115,149 (302)

A proteome-wide association study identifies putative causal proteins for breast cancer risk. [PDF]

Br J Cancer
Abstract Background Genome-wide association studies (GWAS) have identified more than 200 breast cancer risk-associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function.
Zhao T, Xu S, Ping J, Jia G, Dou Y, Henry JE, Zhang B, Guo X, Cote ML, Cai Q, Shu XO, Zheng W, Long J.   +12 more
europepmc   +6 more sources

Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder. [PDF]

Genes (Basel), 2022
Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer risk of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with the PTSD GWAS dataset, respectively, to conduct a ...
Zhang Z, Meng P, Zhang H, Jia Y, Wen Y, Zhang J, Chen Y, Li C, Pan C, Cheng S, Yang X, Yao Y, Liu L, Zhang F.   +13 more
europepmc   +5 more sources

Proteome-Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease. [PDF]

CNS Neurosci Ther
ABSTRACTObjectiveTo identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset and progression of Parkinson's disease (PD) through integrative proteomic and genetic analyses.MethodWe utilized large‐scale plasma and brain protein quantitative trait loci (pQTL) datasets from the deCODE Health ...
Gao C, Zhou H, Liang W, Wen Z, Liao W, Xie Z, Liao C, He L, Sun J, Chen Z, Li D, Yuan N, Huang C, Zhang J.   +13 more
europepmc   +5 more sources

Proteome-wide association study and functional validation identify novel protein markers for pancreatic ductal adenocarcinoma. [PDF]

Gigascience
Abstract   Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy, largely due to the paucity of reliable biomarkers for early detection and therapeutic targeting. Existing blood protein biomarkers for PDAC often suffer from replicability issues, arising from inherent limitations such as ...
Zhu J, Wu K, Liu S, Masca A, Zhong H, Yang T, Ghoneim DH, Surendran P, Liu T, Yao Q, Liu T, Fahle S, Butterworth A, Alam MA, Vadgama JV, Deng Y, Deng HW, Wu C, Wu Y, Wu L.   +19 more
europepmc   +6 more sources

Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster [PDF]

Nature Communications, 2016
How genetic diversity generates complex phenotypes along a continuum remains a fundamental question of biology. Here—applying the emerging SWATH proteomics technology—the authors describe a proteome wide association study (PWAS) of Drosophila wing size ...
Hirokazu Okada, H. Alexander Ebhardt, Sibylle Chantal Vonesch, Ruedi Aebersold, Ernst Hafen   +4 more
doaj   +6 more sources

Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies [PDF]

HGG Advances, 2023
Summary: Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWASs) have discovered hundreds of variants associated with lipids in humans, most ...
Daiwei Zhang, Boran Gao, Qidi Feng, Ani Manichaikul, Gina M. Peloso, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Stacey Gabriel, Namrata Gupta, Joshua D. Smith, Francois Aguet, Kristin G. Ardlie, Thomas W. Blackwell, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Laura J. Scott, Xiang Zhou, Seunggeun Lee   +21 more
doaj   +5 more sources

TIMP4 as a Potential Complementary Biomarker and Therapeutic Target in Membranous Nephropathy: A Multi-Omics Investigation with Clinical Validation [PDF]

Journal of Inflammation Research
Qingsong Chen, Gang Wang, Ruo Zhao, Qiyuan Hu, Jiayun Li, Yuting Wang, Jingyang Ran, Qi Huang, Guiquan Yu, Yanjia Luo, Xiaohui Liao Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ...
Chen Q, Wang G, Zhao R, Hu Q, Li J, Wang Y, Ran J, Huang Q, Yu G, Luo Y, Liao X   +10 more
doaj   +2 more sources

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease [PDF]

Alzheimer's & Dementia, 2023
AbstractBackgroundLeucine‐rich repeat kinase 2 (LRRK2) common gene variants (tagged by rs76904798) are associated with Parkinson’s disease (PD) risk. In a previous study, we found that rs76904798 was associated with CSF GRN levels, but a comprehensive unbiased analysis of associated proteins remains incomplete due to prior focus on cis‐protein ...
Carlos Cruchaga, Daniel Western, Lihua Wang, Jigyasha Timsina, Yi-Chen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Álvarez, Miquel Aguilar, Pau Pástor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García‐González, Itziar de Rojas, Marta Marquié, Merçé Boada, Agustı́n Ruiz, Joel S. Perlmutter, Laura Ibáñez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga, Carlos Cruchaga   +26 more
  +9 more sources

Brain proteome-wide association study implicates novel proteins in depression pathogenesis. [PDF]

Nat Neurosci, 2021
Depression is a common condition, but current treatments are only effective in a subset of individuals. To identify new treatment targets, we integrated depression genome-wide association study (GWAS) results (N = 500,199) with human brain proteomes (N = 376) to perform a proteome-wide association study of depression followed by Mendelian randomization.
Wingo TS, Liu Y, Gerasimov ES, Gockley J, Logsdon BA, Duong DM, Dammer EB, Lori A, Kim PJ, Ressler KJ, Beach TG, Reiman EM, Epstein MP, De Jager PL, Lah JJ, Bennett DA, Seyfried NT, Levey AI, Wingo AP.   +18 more
europepmc   +6 more sources

Integrative analysis of proteome-wide association and transcriptome-wide association study identifies candidate brain proteins associated with insomnia [PDF]

, 2021
Abstract Great progress has been made in identifying risk loci for insomnia by genome-wide association studies (GWAS) analysis, but its association with human brain proteome is unclear. Two insomnia GWAS summary datasets were derived from deCODE (n = 113,006) and 23andMe (n = 1,331,010). Two human brain proteomic datasets were obtained from ROS/
Peilin Meng, Bolun Cheng, Chun’e Li, Huijie Zhang, Shiqiang Cheng, Li Liu, Xuena Yang, Chujun Liang, Yao Yao, Jing Ye, Xiaomeng Chu, Chuyu Pan, Yujing Chen, Jingxi Zhang, Zhen Zhang, Yan Wen, Yumeng Jia, Xiong Guo, Lingyan Liu   +18 more
openalex   +2 more sources