Results 211 to 220 of about 260,383 (299)

BRIGHT Enables High‐SNR Live‐Cell Imaging of Non‐Repetitive Sequences via Bivalent Fluorescent Nanobody‐Mediated Cascade‐Dependent Illumination

Advanced Science, EarlyView.
BRIGHT is a newly developed live‐cell imaging system that integrates cascade amplification with background denoising through the bivalent binding capability and antigen‐dependent stability of a bivalent fluorescent nanobody targeting ALFA peptides.
Lei Feng, Tao Huang, Yanxi Han, Meng Tian, Duo Wang, Zilong Mei, Yu Ma, Yingshuo Ma, Jinming Li, Rui Zhang   +9 more
wiley   +1 more source

Plasma proteins and onset of atherosclerosis: integrating human plasma proteogenomics, transcriptomics and in vivo evidence. [PDF]

J Transl Med
Chen K, Pan Y, Wang Y, Luan M, Yan H, Yu J, Xin D, Zhao Y, Xu X, Li M, Zheng C.   +10 more
europepmc   +1 more source

ADA2 Forms Nuclear Condensates with GCN5 and ATP‐Citrate Lyase (ACL) to Modulate H3K9 Acetylation at Genes Functioning in Rice Meristems

Advanced Science, EarlyView.
This study unveils a novel GAA (GCN5‐ADA2‐ACL) complex that forms nuclear condensates to boost local acetyl‐CoA, facilitating histone acetylation and gene transcription in rice meristems. The research underscores the role of ADA2's disordered region in complex condensation and ACL's role in acetyl‐CoA production.
Yaping Yue, Tingting Lu, Xiaoyuan Guo, Biao Liu, Shiteng Lv, Heba A. M. Abdalla, Xuelei Lai, Ruihui Zhang, Jianpin Guo, Yu Zhao, Dao‐Xiu Zhou, Shaoli Zhou   +11 more
wiley   +1 more source

Evaluating the causal effect of circulating proteome on the risk of Juvenile idiopathic arthritis: an omics pipeline study. [PDF]

Pediatr Rheumatol Online J
Wu X, Luo Q, Luo X, Liu D, Li F, Ma C, Tang X.   +6 more
europepmc   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

Proteome-wide association studies using summary pQTL data of brain, CSF, and plasma identify 30 risk genes of Alzheimer’s disease dementia [PDF]

Tingyang Hu, Qiang Liu, Qile Dai, Aron S. Buchman, Philip L. De Jager, Shinya Tasaki, Yanling Wang, Nicholas T. Seyfried, Philip L. De Jager, Michael P. Epstein, Jingjing Yang   +10 more
openalex   +1 more source

Additional file 2 of PWAS: proteome-wide association study—linking genes and phenotypes by functional variation in proteins

, 2020
Nadav Brandes, Nathan Linial, Michal Linial   +2 more
openalex   +1 more source

Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for cutaneous melanoma. [PDF]

Medicine (Baltimore)
Zhou D, Luo W, Zou J, Zhu X, Hu Z, Jie X, Zhu L, Wu M.   +7 more
europepmc   +1 more source

Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing

Advanced Science, EarlyView.
Sample multiplexing offers a critical solution for boosting throughput and minimizing batch effects in single‐cell sequencing. This review navigates the latest experimental methodologies and computational deconvolution algorithms, bridging the gap between wet‐lab design and analytical success.
Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
wiley   +1 more source

Causal associations between human plasma proteins and prostate cancer identified by proteome-wide Mendelian randomization. [PDF]

Elife
Chen L, Gu Y, Chen Y, Yu W, Zhou Y, Rong Z, Pang X.   +6 more
europepmc   +1 more source