Results 201 to 210 of about 44,050 (232)

ICA1L Is Associated with Small Vessel Disease: A Proteome-Wide Association Study in Small Vessel Stroke and Intracerebral Haemorrhage [PDF]

International Journal of Molecular Sciences, 2022
Small vessel strokes (SVS) and intracerebral haemorrhages (ICH) are acute outcomes of cerebral small vessel disease (SVD). Genetic studies combining both phenotypes have identified three loci associated with both traits. However, the genetic cis-regulation at the protein level associated with SVD has not been studied before.
Natalia Cullell, Elena Muino, Miquel Lledós   +2 more
exaly   +9 more sources

Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder [PDF]

Genes, 2022
Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer risk of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with the PTSD GWAS dataset, respectively, to conduct a ...
, , Zhen Zhang
exaly   +4 more sources

Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia [PDF]

American Journal of Human Genetics
Transcriptome-wide association study (TWAS) tools have been applied to conduct proteome-wide association studies (PWASs) by integrating proteomics data with genome-wide association study (GWAS) summary data. The genetic effects of PWAS-identified significant genes are potentially mediated through genetically regulated protein abundance, thus informing ...
Michael Epstein, Jingjing Yang, Nicholas Seyfried   +2 more
exaly   +4 more sources

The genetic structure of pain in depression patients: A genome-wide association study and proteome-wide association study [PDF]

Journal of Psychiatric Research, 2022
Comparing with the general population, the pain in depression patients has more complex biological mechanism. We aim to explore the etiological mechanism of pain in depression patients from the perspective of genetics.Utilizing the UK Biobank samples with self-reported depression status or PHQ score ≥10, we conducted genome-wide association studies ...
Zhen Zhang, Yujing Chen, Chun’E Li
exaly   +4 more sources

Integrated analysis of proteome-wide and transcriptome-wide association studies identified novel genes and chemicals for vertigo

Brain Communications, 2022
Abstract Vertigo is a leading symptom of various peripheral and central vestibular disorders. Although genome-wide association studies (GWASs) have identified multiple risk variants for vertigo, how these risk variants contribute to the risk of vertigo remains unknown.
Peilin Meng, Shiqiang Cheng, Yumeng Jia   +2 more
exaly   +3 more sources

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Proteome-wide Association Study Provides Insights Into the Genetic Component of Protein Abundance in Psychiatric Disorders

Biological Psychiatry, 2021
Genome-wide association studies have identified multiple risk variants for psychiatric disorders. Nevertheless, how the risk variants confer risk of psychiatric disorders remains largely unknown.We performed proteome-wide association studies to identify genes whose cis-regulated protein abundance change in the human brain were associated with ...
Jiewei Liu, Xiaoyan Li, Xiong-Jian Luo
openaire   +2 more sources

Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma

The American Journal of Human Genetics
We performed a series of integrative analyses including transcriptome-wide association studies (TWASs) and proteome-wide association studies (PWASs) of renal cell carcinoma (RCC) to nominate and prioritize molecular targets for laboratory investigation.
Diptavo Dutta, Xinyu Guo, Timothy D. Winter, Om Jahagirdar, Mark P. Purdue, Diptavo Dutta, Mitchell J. Machiela, Bryan R. Gorman, Timothy Winter, Dayne Okuhara, Sara Cleland, Aida Ferreiro-Iglesias, Paul Scheet, Aoxing Liu, Chao Wu, Samuel O. Antwi, James Larkin, Stênio C. Zequi, Maxine Sun, Keiko Hikino, Ali Hajiran, Keith A. Lawson, Flavio Cárcano, Odile Blanchet, Brian Shuch, Kenneth G. Nepple, Gaëlle Margue, Debasish Sundi, W. Ryan Diver, Maria A.A.K. Folgueira, Adrie van Bokhoven, Florencia Neffa, Kevin M. Brown, Jonathan N. Hofmann, Jongeun Rhee, Meredith Yeager, Nathan R. Cole, Belynda D. Hicks, Michelle R. Manning, Amy A. Hutchinson, Nathaniel Rothman, Wen-Yi Huang, W. Marston Linehan, Adriana Lori, Matthieu Ferragu, Merzouka Zidane-Marinnes, Sérgio Serrano, Wesley J. Magnabosco, null BioBank Japan Project Consortium, Ana Vilas, Ricardo Decia, Florencia Carusso, Laura S. Graham, Kyra Anderson, Mehmet A. Bilen, Cletus Arciero, Isabelle Pellegrin, Solène Ricard, null FinnGen, Ghislaine Scelo, Rosamonde E. Banks, Naveen S. Vasudev, Naeem Soomro, Grant D. Stewart, Adebanji Adeyoju, Stephen Bromage, David Hrouda, Norma Gibbons, Poulam Patel, Mark Sullivan, Andrew Protheroe, Francesca I. Nugent, Michelle J. Fournier, Xiaoyu Zhang, Lisa J. Martin, Maria Komisarenko, Timothy Eisen, Sonia A. Cunningham, Denise C. Connolly, Robert G. Uzzo, David Zaridze, Anush Mukeria, Ivana Holcatova, Anna Hornakova, Lenka Foretova, Vladimir Janout, Dana Mates, Viorel Jinga, Stefan Rascu, Mirjana Mijuskovic, Slavisa Savic, Sasa Milosavljevic, Valérie Gaborieau, Behnoush Abedi-Ardekani, James McKay, Mattias Johansson, Larry Phouthavongsy, Lindsay Hayman, Jason Li, Ilinca Lungu, Stephania M. Bezerra, Aline G. de Souza, Claudia T.G. Sares, Rodolfo B. Reis, Fabio P. Gallucci, Mauricio D. Cordeiro, Mark Pomerantz, Gwo-Shu M. Lee, Matthew L. Freedman, Anhyo Jeong, Samantha E. Greenberg, Alejandro Sanchez, R. Houston Thompson, Vidit Sharma, David D. Thiel, Colleen T. Ball, Diego Abreu, Elaine T. Lam, William C. Nahas, Viraj A. Master, Alpa V. Patel, Jean-Christophe Bernhard, Neal D. Freedman, Pierre Bigot, Rui M. Reis, Leandro M. Colli, Antonio Finelli, Brandon J. Manley, Chikashi Terao, Toni K. Choueiri, Dirce M. Carraro, Richard Houlston, Jeanette E. Eckel-Passow, Philip H. Abbosh, Andrea Ganna, Paul Brennan, Jian Gu, Stephen J. Chanock, Eunji Ha, Katalin Susztak, Mitchell J. Machiela, Stephen J. Chanock, Mark P. Purdue   +142 more
openaire   +2 more sources

Proteome Wide Association Studies of LRRK2 variants identify novel causal and druggable for Parkinson’s disease

2023
Abstract Common and rare variants in the LRRK2 locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remains unknown.
Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga   +25 more
openaire   +1 more source

Proteome-Wide and Transcriptome-Wide Association Studies of Kidney Function

Journal of the American Society of Nephrology, 2021
Pascal Schlosser, Jingning Zhang, Hongbo Liu, Aditya L. Surapaneni, Bing Yu, Eric Boerwinkle, Nilanjan Chatterjee, Katalin Susztak, Anna Kottgen, Josef Coresh, Morgan Grams   +10 more
openaire   +1 more source