Results 21 to 30 of about 115,149 (302)

Integrative analysis of transcriptome and proteome wide association studies prioritized functional genes for obesity [PDF]

Human Genetics, 2023
Abstract Background Genome-wide association studies have identified dozens of genomic loci for obesity. However, functional genes and their detailed genetic mechanisms underlying these loci are mainly unknown. In this study, we conducted an integrative study to prioritize plausibly functional genes by combining information from genome ...
Qi‐Gang Zhao, Xin-Ling Ma, Qian Xu, Zi-Tong Song, Fan Bu, Kuan Li, Bai‐Xue Han, Shanshan Yan, Lei Zhang, Yuan Luo, Yu‐Fang Pei   +10 more
openalex   +3 more sources

Integrated analysis of proteome-wide and transcriptome-wide association studies identified novel genes and chemicals for vertigo [PDF]

Brain Communications, 2022
Abstract Vertigo is a leading symptom of various peripheral and central vestibular disorders. Although genome-wide association studies (GWASs) have identified multiple risk variants for vertigo, how these risk variants contribute to the risk of vertigo remains unknown.
Bolun Cheng, Peilin Meng, Xuena Yang, Shiqiang Cheng, Li Liu, Yumeng Jia, Yan Wen, Lingyan Liu   +7 more
openalex   +3 more sources

Human Brain Proteome-Wide Association Study Implicates Potential Therapeutic Targets for Obesity

, 2023
Qi‐Gang Zhao, Xin-Ling Ma, Qian Xu, Zi-Tong Song, Fan Bu, Kuan Li, Lei Zhang, Yu‐Fang Pei   +7 more
openalex   +2 more sources

The Genetic Structure of Pain in Depression Patients: A Genome-Wide Association Study and Proteome-Wide Association Study [PDF]

Journal of Psychiatric Research, 2022
Comparing with the general population, the pain in depression patients has more complex biological mechanism. We aim to explore the etiological mechanism of pain in depression patients from the perspective of genetics.Utilizing the UK Biobank samples with self-reported depression status or PHQ score ≥10, we conducted genome-wide association studies ...
Zhen Zhang, Li Liu, Huijie Zhang, Chun’e Li, Yujing Chen, Jingxi Zhang, Chuyu Pan, Shiqiang Cheng, Xuena Yang, Peilin Meng, Yao Yao, Dan He, Yumeng Jia, Yan Wen, Lingyan Liu   +14 more
  +5 more sources

Proteome-wide association study identifies novel Alzheimer's disease- associated proteins [PDF]

Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disease, with a critical shortage of effective prevention and treatment options. Here, we aimed to identify proteins whose genetically regulated plasma levels were associated with AD and its related phenotypes.
Lingyun Sun, Guikang Wei, Feiyang Ji, Yihong Ding, Jiayao Fan, Yue Xu, Chunfeng He, Yuan Zhou, Zuyun Liu, Zeyu Sun, Dan Zhou   +10 more
openalex   +2 more sources

Identification and validation of ECM1 as a causal plasma biomarker in knee osteoarthritis through proteome-wide association study and bioinformatics. [PDF]

Medicine (Baltimore)
Wang H, Yao Y, Yin X, Zhang Q.
europepmc   +2 more sources

Methylome-wide association studies and epigenetic biomarker development for 133 mass spectrometry-assessed circulating proteins in 14,671 Generation Scotland participants [PDF]

Genome Biology
Background DNA methylation (DNAm) can regulate gene expression, and its genome-wide patterns (epigenetic scores or EpiScores) can act as biomarkers for complex traits. The relative stability of methylation profiles may enable better assessment of chronic
Josephine A. Robertson, Jakub Bajzik, Spyros Vernardis, Aleksandra D. Chybowska, Daniel L. McCartney, Arturas Grauslys, Jure Mur, Hannah M. Smith, Archie Campbell, Camilla Drake, Hannah Grant, Jamie Pearce, Tom C. Russ, Poppy Adkin, Matthew White, Charles Brigden, Christoph B. Messner, David J. Porteous, Caroline Hayward, Simon R. Cox, Aleksej Zelezniak, Markus Ralser, Matthew R. Robinson, Riccardo E. Marioni   +23 more
doaj   +2 more sources

A Proteome-Wide Association Study Identified Candidate Human Brain Proteins Associated with Coffee Consumption [PDF]

, 2021
Abstract Background Increasing evidence suggests the association between caffeine and the brain and nervous system. However, there is limited research on the genetic associations between coffee consumption subtypes and brain proteome, plasma proteomes, and peripheral metabolites. Methods First, proteome-wide association study (PWAS) of coffee
Chun’e Li, Xiao Liang, Yumeng Jia, Yan Wen, Huijie Zhang, Shiqiang Cheng, Chuyu Pan, Jingxi Zhang, Zhen Zhang, Yujing Chen, Xuena Yang, Peilin Meng, Yao Yao, Feng Zhang, Cuiyan Wu, Sen Wang, Yujie Ning, Xi Wang   +17 more
openalex   +2 more sources

Identification of novel plasma proteins as potential therapeutic targets for benign prostatic hyperplasia: a proteome-wide association study. [PDF]

Transl Androl Urol
Luo X, Wu C, Xiong Y, Wang W, Jiang Q, Liu Z.   +5 more
europepmc   +2 more sources

Multivariate proteome-wide association study to identify causal proteins for Alzheimer disease. [PDF]

Am J Hum Genet
Alzheimer disease (AD) is a complex and progressive neurodegenerative disorder that accounts for the majority of individuals with dementia. Here, we aim to identify causal plasma proteins for AD, shedding light on the etiology of AD. We utilized the latest large-scale plasma proteomic data from the UK Biobank Pharma Proteomics Project (UKB-PPP) and AD ...
Fang L, Xue H, Lin Z, Pan W.
europepmc   +3 more sources