Results 21 to 30 of about 260,383 (299)

The Genetic Structure of Pain in Depression Patients: A Genome-Wide Association Study and Proteome-Wide Association Study [PDF]

Journal of Psychiatric Research, 2022
BACKGROUND Comparing with the general population, the pain in depression patients has more complex biological mechanism. We aim to explore the etiological mechanism of pain in depression patients from the perspective of genetics.
Zhen Zhang, Li Liu, Huijie Zhang, Chun’e Li, Yujing Chen, Jingxi Zhang, Chuyu Pan, Shiqiang Cheng, Xuena Yang, Peilin Meng, Yao Yao, Dan He, Yumeng Jia, Yan Wen, Feng Zhang   +14 more
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Integrative analysis of proteome-wide association and transcriptome-wide association study identifies candidate brain proteins associated with insomnia [PDF]

, 2021
Great progress has been made in identifying risk loci for insomnia by genome-wide association studies (GWAS) analysis, but its association with human brain proteome is unclear.
Peilin Meng, Bolun Cheng, Chun’e Li, Huijie Zhang, Shiqiang Cheng, Li Liu, Xuena Yang, Chujun Liang, Yao Yao, Jing Ye, Xiaomeng Chu, Chuyu Pan, Yujing Chen, Jingxi Zhang, Zhen Zhang, Yan Wen, Yumeng Jia, Xiong Guo, Feng Zhang   +18 more
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Proteome-wide association studies using summary pQTL data of three tissues identified 30 risk genes of Alzheimer’s disease dementia [PDF]

medRxiv
Characterizing the genetic mechanisms underlying Alzheimer's disease (AD) dementia is crucial for developing new therapeutics. Proteome-wide association study (PWAS) integrating proteomics data with genome-wide association study (GWAS) summary data was ...
Tingyang Hu, Qiang Liu, Qile Dai, Randy L. Parrish, Aron S. Buchman, Shinya Tasaki, Nicholas T. Seyfried, Yanling Wang, David A. Bennett, Philip L. De Jager, Michael P. Epstein, Jingjing Yang   +11 more
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TIMP4 as a Potential Complementary Biomarker and Therapeutic Target in Membranous Nephropathy: A Multi-Omics Investigation with Clinical Validation [PDF]

Journal of Inflammation Research
Qingsong Chen, Gang Wang, Ruo Zhao, Qiyuan Hu, Jiayun Li, Yuting Wang, Jingyang Ran, Qi Huang, Guiquan Yu, Yanjia Luo, Xiaohui Liao Department of Nephrology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ...
Chen Q, Wang G, Zhao R, Hu Q, Li J, Wang Y, Ran J, Huang Q, Yu G, Luo Y, Liao X   +10 more
doaj   +2 more sources

Integrating brain proteomes and genetics to identify novel risk genes in chronic widespread musculoskeletal pain [PDF]

Scientific Reports
Chronic widespread musculoskeletal pain (CWP), a core symptom of fibromyalgia, is a complex condition with an unclear pathogenesis. Despite findings from genome-wide association studies (GWAS), translating genetic risk variants into therapeutic targets ...
Zhisen Dai, Yanlin Wu, Huaqing Huang, Huizhe Zheng   +3 more
doaj   +2 more sources

Proteome-Wide Association Studies for Blood Lipids and Comparison with Transcriptome-Wide Association Studies [PDF]

bioRxiv, 2023
Blood lipid traits are treatable and heritable risk factors for heart disease, a leading cause of mortality worldwide. Although genome-wide association studies (GWAS) have discovered hundreds of variants associated with lipids in humans, most of the ...
Daiwei Zhang, Boran Gao, Qidi Feng, Ani Manichaikul, Gina M. Peloso, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Stacey Gabriel, Namrata Gupta, Joshua D. Smith, François Aguet, Kristin Ardlie, Thomas W. Blackwell, Robert E. Gerszten, Stephen S. Rich, Jerome I. Rotter, Laura J. Scott, Xiang Zhou, Seunggeun Lee   +21 more
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PWAS: Proteome-Wide Association Study [PDF]

bioRxiv, 2019
Over the last two decades, GWAS (Genome-Wide Association Study) has become a canonical tool for exploratory genetic research, generating countless gene-phenotype associations.
Nadav Brandes, Nathan Linial, Michal Linial   +2 more
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A Proteome-Wide Association Study Identified Candidate Human Brain Proteins Associated with Coffee Consumption [PDF]

, 2021
Background Increasing evidence suggests the association between caffeine and the brain and nervous system. However, there is limited research on the genetic associations between coffee consumption subtypes and brain proteome, plasma proteomes, and ...
Chun’e Li, Xiao Liang, Yumeng Jia, Yan Wen, Huijie Zhang, Shiqiang Cheng, Chuyu Pan, Jingxi Zhang, Zhen Zhang, Yujing Chen, Xuena Yang, Peilin Meng, Yao Yao, Feng Zhang, Cuiyan Wu, Sen Wang, Yujie Ning, Xi Wang   +17 more
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Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia. [PDF]

Am J Hum Genet
Hu T, Parrish RL, Dai Q, Buchman AS, Tasaki S, Bennett DA, Seyfried NT, Epstein MP, Yang J.   +8 more
europepmc   +2 more sources

Human Brain Proteome-wide Association Study Provides Insights into the Genetic Components of Protein Abundance in Obesity [PDF]

International Journal of Obesity
Yu‐Fang Pei, Qi‐Gang Zhao, Xin-Ling Ma, Qian Xu, ZiTong Song, Fan Bu, Kuan Li, Lei Zhang   +7 more
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