Results 31 to 40 of about 260,383 (299)

Multivariate proteome-wide association study to identify causal proteins for Alzheimer disease. [PDF]

Am J Hum Genet
Fang L, Xue H, Lin Z, Pan W.
europepmc   +2 more sources

Integrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics [PDF]

European Journal of Medical Research
Background This study aimed to explore associations and causality between excessive daytime sleepiness (EDS), narcolepsy, and hypertension. Methods Publicly available data from the National Health and Nutrition Examination Survey (NHANES), genome-wide ...
Shenghui Feng, Xiangfei Liu, Yibo Sun, Yaoyao Cai, Shen Chen, Yan Liang   +5 more
doaj   +2 more sources

Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study [PDF]

Metabolism: Clinical and Experimental, 2023
Alice Giontella, Loukas Zagkos, Milan S. Geybels, Susanna C. Larsson, Ioanna Tzoulaki, Christos S. Mantzoros, Birgitte Andersen, Dipender Gill, Héléne T. Cronjé   +8 more
openalex   +2 more sources

Identification of potential changes in protein abundance associated with post-traumatic stress disorder through brain proteome-wide association study [PDF]

medRxiv
Jiewei Liu, Zhongchun Liu
openalex   +2 more sources

Identifying causal genes for stroke via integrating the proteome and transcriptome from brain and blood

Journal of Translational Medicine, 2022
Background Genome-wide association studies (GWAS) have revealed numerous loci associated with stroke. However, the underlying mechanisms at these loci in the pathogenesis of stroke and effective stroke drug targets are elusive.
Bang-Sheng Wu, Shu-Fen Chen, Shu-Yi Huang, Ya-Nan Ou, Yue-Ting Deng, Shi-Dong Chen, Qiang Dong, Jin-Tai Yu   +7 more
doaj   +1 more source

Identifying causal genes for migraine by integrating the proteome and transcriptome

The Journal of Headache and Pain, 2023
Background While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these variants contribute to the development of migraine.
Shuang-jie Li, Jing-jing Shi, Cheng-yuan Mao, Chan Zhang, Ya-fang Xu, Yu Fan, Zheng-wei Hu, Wen-kai Yu, Xiao-yan Hao, Meng-jie Li, Jia-di Li, Dong-rui Ma, Meng-nan Guo, Chun-yan Zuo, Yuan-yuan Liang, Yu-ming Xu, Jun Wu, Shi-lei Sun, Yong-gang Wang, Chang-he Shi   +19 more
doaj   +1 more source

Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies

Nature Genetics, 2022
Jingning Zhang, Diptavo Dutta, Anna Köttgen, Adrienne Tin, Pascal Schlosser, Morgan E. Grams, Benjamin Harvey, Bing Yu, Eric Boerwinkle, Josef Coresh, Nilanjan Chatterjee   +10 more
openalex   +3 more sources

Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits [PDF]

American Journal of Human Genetics
Henry Wittich, Kristin Ardlie, Kent D. Taylor, Peter Durda, Yongmei Liu, Anna V. Mikhaylova, Chris Gignoux, Michael H. Cho, Stephen S. Rich, Jerome I. Rotter, Ani Manichaikul, Hae Kyung Im, Heather E. Wheeler   +12 more
openalex   +2 more sources

Bacterial riboproteogenomics : the era of N-terminal proteoform existence revealed [PDF]

, 2020
With the rapid increase in the number of sequenced prokaryotic genomes, relying on automated gene annotation became a necessity. Multiple lines of evidence, however, suggest that current bacterial genome annotations may contain inconsistencies and are ...
Fijalkowska, Daria, Fijalkowski, Igor, Van Damme, Petra, Willems, Patrick   +3 more
core   +2 more sources

Systems biology in inflammatory bowel diseases [PDF]

, 2014
Purpose of review: Ulcerative colitis (UC) and Crohn’s Disease (CD) are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the US.
Iliopoulos, D, Koukos, G, Polytarchou, C
core   +1 more source