Results 31 to 40 of about 115,149 (302)
PWAS: Proteome-Wide Association Study [PDF]
, 2019 AbstractOver the last two decades, GWAS (Genome-Wide Association Study) has become a canonical tool for exploratory genetic research, generating countless gene-phenotype associations. Despite its accomplishments, several limitations and drawbacks still hinder its success, including low statistical power and obscurity about the causality of implicated ...
Nadav Brandes +2 more
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Human Brain Proteome-wide Association Study Provides Insights into the Genetic Components of Protein Abundance in Obesity [PDF]
International Journal of ObesityAbstract Backgrounds:Genome-wide association studies have identified multiple genetic variants associated with obesity. However, most obesity-associated loci were waiting to be translated into new biological insights. Given the critical role of brain in obesity development, we sought to explore whether obesity-associated genetic variants could ...
Yu‐Fang Pei +7 more
openalex +3 more sources
Sex‐Specific Causal Genes for Alzheimer’s Disease via Proteome‐Wide Association Studies
Alzheimer's & DementiaAbstractBackgroundWomen are at higher risk of developing Alzheimer’s disease (AD). Sex differences in AD pathobiology and prevalence appear to be partially attributed to genetics, but sex‐stratified genome‐wide association studies (GWAS) of AD have demonstrated a relative paucity of associated variants, which may reflect challenges of limited power ...
Danielle Marie Reid, Michaël E. Belloy
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Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia. [PDF]
Am J Hum GenetTranscriptome-wide association study (TWAS) tools have been applied to conduct proteome-wide association studies (PWASs) by integrating proteomics data with genome-wide association study (GWAS) summary data. The genetic effects of PWAS-identified significant genes are potentially mediated through genetically regulated protein abundance, thus informing ...
Hu T +8 more
europepmc +3 more sources
Journal of Translational Medicine, 2022 Background Genome-wide association studies (GWAS) have revealed numerous loci associated with stroke. However, the underlying mechanisms at these loci in the pathogenesis of stroke and effective stroke drug targets are elusive.
Bang-Sheng Wu +7 more
doaj +1 more source
Identifying causal genes for migraine by integrating the proteome and transcriptome
The Journal of Headache and Pain, 2023 Background While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these variants contribute to the development of migraine.
Shuang-jie Li +19 more
doaj +1 more source
Omnibus proteome-wide association study (PWAS-O) identified 43 risk genes for Alzheimer’s disease dementia [PDF]
, 2022 AbstractProteome-wide association study (PWAS) integrating proteomics data with GWAS data is a powerful tool to identify risk genes for complex diseases, which can inform disease mechanisms with genetic effects mediated through protein abundance. We propose a novel omnibus method to improve PWAS power by modeling unknown genetic architectures with ...
Tingyang Hu +8 more
openalex +2 more sources
Bacterial riboproteogenomics : the era of N-terminal proteoform existence revealed [PDF]
, 2020 With the rapid increase in the number of sequenced prokaryotic genomes, relying on automated gene annotation became a necessity. Multiple lines of evidence, however, suggest that current bacterial genome annotations may contain inconsistencies and are ...
Fijalkowska, Daria +3 more
core +2 more sources
Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study [PDF]
Metabolism, 2023 Fibroblast growth factor 21 (FGF21) has demonstrated efficacy for reducing liver fat and reversing non-alcoholic steatohepatitis in phase 2 clinical trials. It is also postulated to have anti-fibrotic effects and therefore may be amenable to repurposing for the prevention and treatment of chronic kidney disease (CKD).We leverage a missense genetic ...
Alice Giontella +8 more
openalex +6 more sources
Systems biology in inflammatory bowel diseases [PDF]
, 2014 Purpose of review: Ulcerative colitis (UC) and Crohn’s Disease (CD) are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the US.
Iliopoulos, D, Koukos, G, Polytarchou, C
core +1 more source