Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease [PDF]
, 2016 The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD.
Heerspink, Hiddo J.L. +2 more
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Glycomic analysis of high density lipoprotein shows a highly sialylated particle. [PDF]
, 2014 Many of the functional proteins and lipids in high density lipoprotein (HDL) particles are potentially glycosylated, yet very little is known about the glycoconjugates of HDL.
German, J Bruce +6 more
core +1 more source
PLOS GeneticsGenome-wide association studies (GWAS) performed on large cohort and biobank datasets have identified many genetic loci associated with Alzheimer’s disease (AD). However, the younger demographic of biobank participants relative to the typical age of late-onset AD has resulted in an insufficient number of AD cases, limiting the statistical power of GWAS
Ruoyu He +3 more
openalex +4 more sources
Pharmacoproteomic characterisation of human colon and rectal cancer [PDF]
, 2017 Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome-guided pre-clinical drug sensitivity studies are only beginning to emerge.
Domingo, Enric +19 more
core +1 more source
Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection. [PDF]
, 2016 Novel biomarkers and non-invasive diagnostic methods are urgently needed for the screening of gastric cancer to reduce its high mortality. We employed quantitative proteomics approach to develop discriminatory biomarker signatures from human saliva for ...
Cao, Cheng-Xi +9 more
core +5 more sources
Proceedings of the EuBIC Winter School 2019 [PDF]
, 2019 The 2019 European Bioinformatics Community (EuBIC) Winter School was held from January 15th to January 18th 2019 in Zakopane, Poland. This year’s meeting was the third of its kind and gathered international researchers in the field of (computational ...
Bittremieux, Wout +9 more
core +4 more sources
Linear and non-linear proteome-wide association studies provide novel insight into venous thromboembolism [PDF]
Nature CommunicationsVenous thromboembolism is a life-threatening vascular event with high prevalence and genetic determinants. PWAS has become a popular strategy to identify therapeutic targets of complex diseases. However, the current PWAS model only considers the linear relationship between protein and disease.
Yifan Kong +9 more
openalex +2 more sources
A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. [PDF]
, 2015 A variety of cellular pathways are regulated by protein modifications with ubiquitin-family proteins. SUMO, the Small Ubiquitin-like MOdifier, is covalently attached to lysine on target proteins via a cascade reaction catalyzed by E1, E2, and E3 enzymes.
Albuquerque, Claudio P +5 more
core +4 more sources
Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? [PDF]
, 2006 The organization and mining of malaria genomic and post-genomic data is highly motivated by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data
Bastien, Olivier +14 more
core +5 more sources
Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus [PDF]
, 2018 Background: Systematic lupus erythematosus (SLE) is characterized with various complications which can cause serious organ damage in the human body. Despite the significant improvements in disease management of SLE patients, the non-invasive diagnosis ...
Burkly, L.C. +6 more
core +1 more source