Results 61 to 70 of about 115,149 (302)

Associations of plasma protein levels with risk of colorectal cancer: a proteome-wide Mendelian randomization study [PDF]

Clinical Proteomics
Abstract Background The treatment of advanced or metastatic colorectal cancer (CRC) poses a global challenge. Mendelian Randomization (MR) has been primarily applied for repurposing licensed drugs and uncovering new therapeutic targets. Objective This study aims to systematically identify potential plasma protein targets for CRC using ...
Zhen-Kun Pan, Menghua Wu, Shi H, Yong-Jian Ni, Quan-Li Geng, Jinsheng Ye   +5 more
openalex   +2 more sources

Elucidating the susceptibility to breast cancer: an in-depth proteomic and transcriptomic investigation into novel potential plasma protein biomarkers

Frontiers in Molecular Biosciences
Objectives: This study aimed to identify plasma proteins that are associated with and causative of breast cancer through Proteome and Transcriptome-wide association studies combining Mendelian Randomization.Methods: Utilizing high-throughput datasets, we
Yang Wang, Kexin Yi, Baoyue Chen, Bailin Zhang, Gao Jidong, Gao Jidong   +5 more
doaj   +1 more source

Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions [PDF]

, 2016
Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis.
Ben Mamoun, Choukri, Brancato, Jana, Chibucos, Marcus, Colinge, Jacques, Cornillot, Emmanuel, Crabtree, Jonathan, Dwivedi, Ankit, Fraser, Claire M., Frutos, Roger, Gotia, Hanzel T., Hung, Chris, Ifeonu, Olukemi O., Krause, Peter J., Kumar, Vidya, Kumari, Priti, Lawres, Lauren, McCracken, Carrie, Molina, Douglas M., Orvis, Joshua, Ott, Sandy, Pablo, Jozelyn V., Pazzi, Joseph E., Reynes, Christelle, Sadzewicz, Lisa, Sengamalay, Naomi, Shetty, Amol C., Silva, Joana C., Su, Qi, Tallon, Luke, Tretina, Kyle, Usmani-Brown, Sahar, Virji, Azan Z.   +31 more
core   +3 more sources

Serum proteomics of active tuberculosis patients and contacts reveals unique processes activated during Mycobacterium tuberculosis infection. [PDF]

, 2020
Tuberculosis (TB) is the most lethal infection among infectious diseases. The specific aim of this study was to establish panels of serum protein biomarkers representative of active TB patients and their household contacts who were either infected (LTBI)
Anibarro, L, Carrera, M, Estévez, O, Gallardo, JM, Gomes-Maueia, C, González-Fernández, Á, Mateos, J, Medina, I, Mussá, T, Nguilichane, A, Pallarés, Á, Reljic, R   +11 more
core   +2 more sources

Structural Prediction of Protein–Protein Interactions by Docking: Application to Biomedical Problems [PDF]

, 2018
A huge amount of genetic information is available thanks to the recent advances in sequencing technologies and the larger computational capabilities, but the interpretation of such genetic data at phenotypic level remains elusive.
Barradas-Bautista, Didier, Fernández-Recio, Juan, Pallara, Chiara, Rosell, Mireia   +3 more
core   +2 more sources

Integrative Analysis of Proteome-wide Association Studies and Functional Enrichment Analysis to Identify Genes and Chemicals Associated with Alcohol Dependence

Journal of Addiction Medicine, 2022
Objectives Alcohol dependence accounts for a large proportion of the global burden of disease and disability. This study aims to investigate the candidate genes and chemicals associated with alcohol dependence. Methods Using data from published alcohol dependence genome-wide ...
Zhang, Jingxi, Meng, Peilin, Yao, Yao, Zhang, Huijie, Pan, Chuyu, Li, Chun'e, Chen, Yujing, Zhang, Zhen, Cheng, Shiqiang, Liu, Li, Yang, Xuena, Jia, Yumeng, Zhang, Feng   +12 more
openaire   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Identifying novel potential drug targets for endometriosis via plasma proteome screening

Frontiers in Endocrinology
BackgroundEndometriosis (EM) is a chronic painful condition that predominantly affects women of reproductive age. Currently, surgery or medication can only provide limited symptom relief.
Tian Tao, Xiaoyu Mo, Liangbin Zhao
doaj   +1 more source

Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age

Nature Communications, 2019
Cognitive abilities tend to decline over time in advanced age, yet some individuals experience stable abilities or rapid decline. Here the authors present a proteome-wide association study of cognitive trajectory, and identify 38 proteins associated with
Aliza P. Wingo, Eric B. Dammer, Michael S. Breen, Benjamin A. Logsdon, Duc M. Duong, Juan C. Troncosco, Madhav Thambisetty, Thomas G. Beach, Geidy E. Serrano, Eric M. Reiman, Richard J. Caselli, James J. Lah, Nicholas T. Seyfried, Allan I. Levey, Thomas S. Wingo   +14 more
doaj   +1 more source

Protein-Based Immunome Wide Association Studies (PIWAS) for the Discovery of Significant Disease-Associated Antigens

Frontiers in Immunology, 2021
Identification of the antigens associated with antibodies is vital to understanding immune responses in the context of infection, autoimmunity, and cancer.
Winston A. Haynes, Kathy Kamath, Rebecca Waitz, Patrick S. Daugherty, John C. Shon   +4 more
doaj   +1 more source