Results 101 to 110 of about 447,819 (251)

A time-resolved multi-omic atlas of the developing mouse stomach

open access: yesNature Communications, 2018
The mammalian stomach is a complex organ with diverse roles in health and disease. Here, the authors integrate proteomics and transcriptomics to analyze the mouse stomach at 15 time points during development, providing molecular level insights into ...
Xianju Li   +12 more
doaj   +1 more source

A protein sequence-based deep transfer learning framework for identifying human proteome-wide deubiquitinase-substrate interactions

open access: yesNature Communications
Protein ubiquitination regulates a wide range of cellular processes. The degree of protein ubiquitination is determined by the delicate balance between ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination.
Yuan Liu   +10 more
doaj   +1 more source

Nuclear and cytoplasmic specific RNA binding proteome enrichment and its changes upon ferroptosis induction

open access: yesNature Communications
The key role of RNA-binding proteins (RBPs) in posttranscriptional regulation of gene expression is intimately tied to their subcellular localization. Here, we show a subcellular-specific RNA labeling method for efficient enrichment and deep profiling of
Haofan Sun   +4 more
doaj   +1 more source

A Bioinformatics View of Glycan–Virus Interactions

open access: yesViruses, 2019
Evidence of the mediation of glycan molecules in the interaction between viruses and their hosts is accumulating and is now partially reflected in several online databases. Bioinformatics provides convenient and efficient means of searching, visualizing,
Philippe Le Mercier   +6 more
doaj   +1 more source

Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology [PDF]

open access: green, 2000
Steven P. Gygi   +4 more
openalex   +1 more source

An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

open access: yesNature Communications, 2017
Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and costly.
Yang Li   +12 more
doaj   +1 more source

Stallion Epididymal Fluid Proteome: Qualitative and Quantitative Characterization; Secretion and Dynamic Changes of Major Proteins1 [PDF]

open access: bronze, 2000
Sophie Fouchécourt   +4 more
openalex   +1 more source

NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression

open access: yesNature Communications
Niemann-Pick disease type C protein 1 (NPC1), classically associated with cholesterol transport and viral entry, has an emerging role in cancer biology.
Shuangyan Li   +7 more
doaj   +1 more source

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