Results 101 to 110 of about 538,471 (385)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Dysbiosis of skin microbiome and gut microbiome in melanoma progression

BMC Microbiology, 2022
Background The microbiome alterations are associated with cancer growth and may influence the immune system and response to therapy. Particularly, the gut microbiome has been recently shown to modulate response to melanoma immunotherapy.
Chahrazed Mekadim, Helena Kupcova Skalnikova, Jana Cizkova, Veronika Cizkova, Anna Palanova, Vratislav Horak, Jakub Mrazek   +6 more
doaj   +1 more source

SLoMo: automated site localization of modifications from ETD/ECD mass spectra [PDF]

, 2009
Recently, software has become available to automate localization of phosphorylation sites from CID data and to assign associated confidence scores. We present an algorithm, SLoMo (Site Localization of Modifications), which extends this capability to ETD ...
Bailey, Christopher M, Cooper, Helen J., Cunningham, Debbie L, Heath, John K, Sweet, Steve M M, Zeller, Martin   +5 more
core   +1 more source

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis*

Molecular & Cellular Proteomics, 2012
Most proteomic studies use liquid chromatography coupled to tandem mass spectrometry to identify and quantify the peptides generated by the proteolysis of a biological sample.
Ludovic C. Gillet, Pedro Navarro, S. Tate, H. Röst, N. Selevsek, L. Reiter, R. Bonner, R. Aebersold   +7 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7

Scientific Reports, 2022
The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechanisms in various malignancies, leading to aberrant Rho GTPase signaling and thus facilitating cancer progression.
Yannick Frey, Mirita Franz-Wachtel, Boris Macek, Monilola A. Olayioye   +3 more
doaj   +1 more source

Defining the core proteome of the chloroplast envelope membranes [PDF]

, 2013
High-throughput protein localization studies require multiple strategies. Mass spectrometric analysis of defined cellular fractions is one of the complementary approaches to a diverse array of cell biological methods. In recent years, the protein content
Ibrahim, Mohamed, Karas, Michael, Leisegang, Matthias, Mirus, Oliver, Müller, Bernd, Papasotiriou, Dimitrios, Schleiff, Enrico, Schorge, Tobias, Simm, Stefan, Sommer, Maik Sascha   +9 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Hybrid Spectral Library Combining DIA-MS Data and a Targeted Virtual Library Substantially Deepens the Proteome Coverage [PDF]

, 2020
Ronghui Lou, Pan Tang, Kang Ding, Shanshan Li, Cuiping Tian, Yunxia Li, Suwen Zhao, Yaoyang Zhang, Wenqing Shui   +8 more
openalex   +1 more source

A selective c-Met and Trks inhibitor Indo5 suppresses hepatocellular carcinoma growth

Journal of Experimental & Clinical Cancer Research, 2019
Background Human hepatocellular carcinoma (HCC) lacks effective curative therapy and there is an urgent need to develop a novel molecular-targeted therapy for HCC. Selective tyrosine kinase inhibitors have shown promise in treating cancers including HCC.
Teng Luo, Shou-Guo Zhang, Ling-Fei Zhu, Fei-Xiang Zhang, Wei Li, Ke Zhao, Xiao-Xue Wen, Miao Yu, Yi-Qun Zhan, Hui Chen, Chang-Hui Ge, Hui-Ying Gao, Lin Wang, Xiao-Ming Yang, Chang-Yan Li   +14 more
doaj   +1 more source