Results 101 to 110 of about 461,354 (348)

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

bioRxiv, 2019
The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels.
Jie Zheng, Valeriia Haberland, D. Baird, V. Walker, P. Haycock, Alex Gutteridge, T. Richardson, James R. Staley, B. Elsworth, S. Burgess, B. Sun, J. Danesh, H. Runz, J. Maranville, H. Martin, J. Yarmolinsky, Charles Laurin, M. Holmes, J. Liu, K. Estrada, L. McCarthy, M. Hurle, D. Waterworth, M. Nelson, A. Butterworth, G. Smith, G. Hemani, R. Scott, Tom R. Gaunt   +28 more
semanticscholar   +1 more source

Advances and Utility of the Human Plasma Proteome.

Journal of Proteome Research, 2021
The study of proteins circulating in blood offers tremendous opportunities to diagnose, stratify, or possibly prevent diseases. With recent technological advances and the urgent need to understand the effects of COVID-19, the proteomic analysis of blood ...
E. Deutsch, G. Omenn, Zhi Sun, Michal Maes, M. Pernemalm, K. K. Palaniappan, N. Letunica, Y. Vandenbrouck, V. Brun, S. Tao, Xiaobo Yu, Philipp E. Geyer, V. Ignjatovic, R. Moritz, J. Schwenk   +14 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Defining the core proteome of the chloroplast envelope membranes [PDF]

, 2013
High-throughput protein localization studies require multiple strategies. Mass spectrometric analysis of defined cellular fractions is one of the complementary approaches to a diverse array of cell biological methods. In recent years, the protein content
Ibrahim, Mohamed, Karas, Michael, Leisegang, Matthias, Mirus, Oliver, Müller, Bernd, Papasotiriou, Dimitrios, Schleiff, Enrico, Schorge, Tobias, Simm, Stefan, Sommer, Maik Sascha   +9 more
core   +2 more sources

Vibrio harveyi Infection Significantly Alters Amino Acid and Carbohydrate Metabolism in Whiteleg Shrimp, Litopenaeus vannamei

Metabolites, 2020
Vibrio harveyi is one of the pathogens that threaten the shrimp farming industry. However, metabolic changes induced by V. harveyi infection in shrimp remain unknown. In this study, we first conducted high resolution-magic angle spinning (HR-MAS) nuclear
Seohee Ma, Ahran Kim, Wonho Lee, Seonghye Kim, Sujin Lee, Dahye Yoon, Jin-Sol Bae, Chan-Il Park, Suhkmann Kim   +8 more
doaj   +1 more source

The 2022 Report on the Human Proteome from the HUPO Human Proteome Project.

Journal of Proteome Research, 2022
The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 407 (93.2%) of the 19 750 predicted proteins coded in the human genome, a net gain ...
G. Omenn, Lydie Lane, C. Overall, C. Pineau, N. Packer, I. Cristea, C. Lindskog, S. Weintraub, S. Orchard, M. Roehrl, E. Nice, Siqi Liu, N. Bandeira, Yu‐Ju Chen, T. Guo, R. Aebersold, R. Moritz, E. Deutsch   +17 more
semanticscholar   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Proteomic Analysis of Chloroplast-to-Chromoplast Transition in Tomato Reveals Metabolic Shifts Coupled with Disrupted Thylakoid Biogenesis Machinery and Elevated Energy-Production Components [PDF]

, 2012
A comparative proteomic approach was performed to identify differentially expressed proteins in plastids at three stages of tomato(Solanum lycopersicum) fruit ripening (mature-green, breaker, red). Stringent curation and processing of the data from three
Alba, Aldridge, Altschul, Andersson, Andon, Armbruster, Asano, Baginsky, Balmer, Bannai, Barry, Barsan, Benjamini, Benning, Bian, Birtić, Blanke, Booth, Botella-Pavía, Bouvier, Bouyssié, Bramley, Bräutigam, Cai, Camara, Chen, Chen, Cho, Deborde, Delmar, Delmar, Demartini, Dieterle, Egea, Egea, Emanuelsson, Emes, Fan, Faurobert, Ferro, Fischer, Harris, Heazlewood, Heazlewood, Hetherington, Huang, Issaq, Jebanathirajah, Jeong, Jimenez, Kahlau, Kato, Kato, Kleffmann, Krech, Lee, Li, Li, Liu, Liu, Liu, Ljubesić, Lopez-Juez, Lundquist, Lytovchenko, Maple, Maple, Marano, McAndrew, Millar, Moing, Neta-Sharir, Niewiadomski, Onishi, Osorio, Palma, Paoletti, Pech, Peng, Pierleoni, Pirrello, Plücken, Ren, Richly, Rocco, Rutschow, Schauer, Seigneurin-Berny, Shipman-Roston, Siddique, Simkin, Small, Smith, Spurr, Su, Sun, Suzuki, Thelen, Thimm, Thomson, Tiwari, Torgrip, van Wijk, Vitha, von Zychlinski, Waters, Yakir-Tamang, Zeng, Zhang, Zhu, Zybailov   +110 more
core   +1 more source

Functional proteomics

Clinica Chimica Acta, 2005
With the increase in the number of genome sequencing projects, there is a concomitant exponential growth in the number of protein sequences whose function is still unknown. Functional proteomics constitutes an emerging research area in the proteomic field whose approaches are addressed towards two major targets: the elucidation of the biological ...
MONTI, MARIA, ORRU S, PAGNOZZI D, PUCCI, PIETRO   +3 more
openaire   +4 more sources

Simulated digestions of free oligosaccharides and mucin-type O-glycans reveal a potential role for Clostridium perfringens

Scientific Reports
The development of a stable human gut microbiota occurs within the first year of life. Many open questions remain about how microfloral species are influenced by the composition of milk, in particular its content of human milk oligosaccharides (HMOs ...
Andrew G. McDonald, Frédérique Lisacek
doaj   +1 more source