Results 111 to 120 of about 205,179 (309)
Large‐Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain
Advanced Science, EarlyView.This study delineates both common and site‐specific proteins linked to various chronic pain conditions, elucidating their implications across molecular pathways and health status. These findings, particularly those proteins with genetic causal links to pain or predictive capabilities, have the potential to significantly benefit both research and ...
Ze‐Yu Li +17 more
wiley +1 more source
A time-resolved multi-omic atlas of the developing mouse stomach
Nature Communications, 2018 The mammalian stomach is a complex organ with diverse roles in health and disease. Here, the authors integrate proteomics and transcriptomics to analyze the mouse stomach at 15 time points during development, providing molecular level insights into ...
Xianju Li +12 more
doaj +1 more source
Amino acid metabolism conflicts with protein diversity [PDF]
arXiv, 2014 The twenty protein coding amino acids are found in proteomes with different relative abundances. The most abundant amino acid, leucine, is nearly an order of magnitude more prevalent than the least abundant amino acid, cysteine. Amino acid metabolic costs differ similarly, constraining their incorporation into proteins.
arxiv
The Yeast Protein Database (YPD): a curated proteome database for Saccharomyces cerevisiae [PDF]
, 1998 Peter E. Hodges
openalex +1 more source
Advanced Science, EarlyView.Schematic diagram of the working model of TRAF3IP3 in the coordination of ER stress and autophagy related apoptosis in lung cancer cells. Abstract TNF receptor‐associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation.
Guang Zhao +11 more
wiley +1 more source
Nature CommunicationsThe key role of RNA-binding proteins (RBPs) in posttranscriptional regulation of gene expression is intimately tied to their subcellular localization. Here, we show a subcellular-specific RNA labeling method for efficient enrichment and deep profiling of
Haofan Sun +4 more
doaj +1 more source
2‐D Proteome analysis protocols, by Andrew J. Link, Ed. 1999. Totowa, New Jersey: Humana Press. 704 pp. $89.50 (hardcover) [PDF]
, 1999 Julio E. Celis
openalex +1 more source
Advanced Science, EarlyView.αPD‐1 therapy has left an indelible mark in the field of NSCLC treatment; however, its efficacy is limited in clinical practice owing to the effector T‐cell exhaustion. These findings underscore CK2B as a promising target for overcoming the exhaustion of effector CD8+ T cells, thereby enhancing the efficacy of αPD‐1 and adoptive cell therapies in NSCLC.
Shaochuan Liu +15 more
wiley +1 more source
Advanced Science, EarlyView.Ca2+/calmodulin‐dependent kinase II (CaMKII) activation is likely driven by oxidative stress, particularly excessive reactive oxygen species (ROS) production. This study identifies P21‐activated kinase 2 (Pak2) as a novel regulator of ROS‐induced CaMKII activation and abnormal Ca2⁺ dynamics in acute adrenergic and chronic pressure‐overload stressed ...
Tao Li +21 more
wiley +1 more source
Nature Communications, 2017 Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and costly.
Yang Li +12 more
doaj +1 more source