Results 121 to 130 of about 437,208 (323)
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz+2 more
wiley +1 more source
Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum+28 more
wiley +1 more source
Human Sperm Proteome: Immunodominant Sperm Surface Antigens Identified with Sera from Infertile Men and Women1 [PDF]
Jagathpala Shetty+5 more
openalex +1 more source
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua+9 more
wiley +1 more source
The Yeast Protein Database (YPD): a curated proteome database for Saccharomyces cerevisiae [PDF]
Peter E. Hodges
openalex +1 more source
High‐Speed Raman Readout of Single Polypeptides via Plasmonic Nanopores
A label‐free method is presented for single‐protein investigation using plasmonic nanopores that enable stable, cost‐effective Raman detection of polypeptides in real time. An average of 6 photons is measured during a dwell time of 7 microseconds per amino acid.
Foroogh Khozeymeh Sarbishe+11 more
wiley +1 more source
Protein ubiquitination regulates a wide range of cellular processes. The degree of protein ubiquitination is determined by the delicate balance between ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination.
Yuan Liu+10 more
doaj +1 more source
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao+14 more
wiley +1 more source
The key role of RNA-binding proteins (RBPs) in posttranscriptional regulation of gene expression is intimately tied to their subcellular localization. Here, we show a subcellular-specific RNA labeling method for efficient enrichment and deep profiling of
Haofan Sun+4 more
doaj +1 more source
Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and costly.
Yang Li+12 more
doaj +1 more source