Results 11 to 20 of about 195,001 (261)
Military Medical Research, 2023 The rapid development of genome editing technology has brought major breakthroughs in the fields of life science and medicine. In recent years, the clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing toolbox has been ...
Zhen-Hua Li +4 more
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Frontiers in Microbiology, 2019 Lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria provide the first line of defense against antibiotics and other harmful compounds. LPS biosynthesis critically depends on LpxC catalyzing the first committed enzyme in this process.
Nikolas Thomanek +7 more
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Current Protocols in Protein Science, 2006 AbstractThis unit describes strategies for studying the proteomes of organelles, which is one example of targeted proteomics. It relies heavily on previously published units dealing with organelle preparation, protein solubilization, and proteomics techniques. A specific commentary for organelle proteomics is provided.
Lescuyer, Pierre +3 more
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BMC Molecular and Cell Biology, 2021 Background One striking feature of the large KRAB domain-containing zinc finger protein (KZFP) family is its rapid evolution, leading to hundreds of member genes with various origination time in a certain mammalian genome. However, a comprehensive genome-
Pan Shen +6 more
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Proteomic overview of hepatocellular carcinoma cell lines and generation of the spectral library
Scientific Data, 2022 Measurement(s) Proteome of hepatocellular carcinoma cell lines Technology Type(s) Liquid chromatography-tandem mass spectrometry Sample Characteristic - Organism Homo ...
Mingchao Wang +6 more
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Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach
Biology Direct, 2018 Background One of the main current challenges in computational biology is to make sense of the huge amounts of multidimensional experimental data that are being produced.
Léon-Charles Tranchevent +7 more
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High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth
BMC Medicine, 2022 Background Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for clinical use.
Zhihua Wang +10 more
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Cell Death and Disease, 2023 BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated the pathophysiological role of BRISC in acute
Wen Zhang +20 more
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Proteoforms expand the world of microproteins and short open reading frame-encoded peptides
iScience, 2023 Summary: Microproteins and short open reading frame-encoded peptides (SEPs) can, like all proteins, carry numerous posttranslational modifications. Together with posttranscriptional processes, this leads to a high number of possible distinct protein ...
Liam Cassidy +2 more
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Toward an understanding of the protein interaction network of the human liver
Molecular Systems Biology, 2011 Proteome‐scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery.
Jian Wang +37 more
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