Results 21 to 30 of about 437,208 (323)

Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach

Biology Direct, 2018
Background One of the main current challenges in computational biology is to make sense of the huge amounts of multidimensional experimental data that are being produced.
Léon-Charles Tranchevent, Petr V. Nazarov, Tony Kaoma, Georges P. Schmartz, Arnaud Muller, Sang-Yoon Kim, Jagath C. Rajapakse, Francisco Azuaje   +7 more
doaj   +1 more source

High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth

BMC Medicine, 2022
Background Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for clinical use.
Zhihua Wang, Miaomiao Wang, Mengxin Zhang, Kaikun Xu, Xinshuai Zhang, Yi Xie, Yiming Zhang, Cheng Chang, Xiaolu Li, Aihua Sun, Fuchu He   +10 more
doaj   +1 more source

proteomics technologies: Probing the proteome [PDF]

Nature, 2003
The completion of the human genome sequence, coupled with analytical techniques such as mass spectrometry, has fuelled interest in proteomics. Diane Gershon reports.
openaire   +3 more sources

Dataset containing physiological amounts of spike-in proteins into murine C2C12 background as a ground truth quantitative LC-MS/MS reference

Data in Brief, 2022
In this article, we present a data dependent acquisition (DDA) dataset which was generated as a reference and ground truth quantitative dataset. While initially used to compare samples measured with DDA and data independent acquisition (DIA) (Barkovits ...
Julian Uszkoreit, Katalin Barkovits, Sandra Pacharra, Kathy Pfeiffer, Simone Steinbach, Katrin Marcus, Martin Eisenacher   +6 more
doaj  

Proteomic overview of hepatocellular carcinoma cell lines and generation of the spectral library

Scientific Data, 2022
Measurement(s) Proteome of hepatocellular carcinoma cell lines Technology Type(s) Liquid chromatography-tandem mass spectrometry Sample Characteristic - Organism Homo ...
Mingchao Wang, Shuang Weng, Chaoying Li, Ying Jiang, Xiaohong Qian, Ping Xu, Wantao Ying   +6 more
doaj   +1 more source

Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity [PDF]

, 2019
Background: Salmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal ...
Barbé, Barbara, Deborggraeve, Stijn, Gevaert, Kris, Jacobs, Jan, Saleh, Sara, Staes, An, Timmerman, Evy, Van Puyvelde, Sandra   +7 more
core   +2 more sources

Conserved paradoxical relationships among the evolutionary, structural and expressional features of KRAB zinc-finger proteins reveal their special functional characteristics

BMC Molecular and Cell Biology, 2021
Background One striking feature of the large KRAB domain-containing zinc finger protein (KZFP) family is its rapid evolution, leading to hundreds of member genes with various origination time in a certain mammalian genome. However, a comprehensive genome-
Pan Shen, Aishi Xu, Yushan Hou, Huqiang Wang, Chao Gao, Fuchu He, Dong Yang   +6 more
doaj   +1 more source

Proteomic Approach for Extracting Cytoplasmic Proteins from Streptococcus sanguinis using Mass Spectrometry [PDF]

, 2017
Streptococcus sanguinis is a commensal and early colonizer of oral cavity as well as an opportunistic pathogen of infectious endocarditis. Extracting the soluble proteome of this bacterium provides deep insights about the physiological dynamic changes ...
Elrami, Fadi, Nelson, Kristina, Xu, Ping
core   +3 more sources

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury

Cell Death and Disease, 2023
BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated the pathophysiological role of BRISC in acute
Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, Xian Liu, Dong-Xu Li, Yang Xiao, Xu Chen, Ya-Ting Li, Yi-Qun Zhan, Shen-Si Xiang, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Zhi-Qiang Ge, Xiao-Ming Yang, Rong-Hua Yin   +20 more
doaj   +1 more source

Constrained Allocation Flux Balance Analysis [PDF]

, 2016
New experimental results on bacterial growth inspire a novel top-down approach to study cell metabolism, combining mass balance and proteomic constraints to extend and complement Flux Balance Analysis.
De Martino, Andrea, Hwa, Terence, Marinari, Enzo, Martin, Olivier C., Mori, Matteo   +4 more
core   +6 more sources