Results 41 to 50 of about 447,819 (251)

Toward an understanding of the protein interaction network of the human liver

Molecular Systems Biology, 2011
Proteome‐scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery.
Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang   +37 more
doaj   +1 more source

Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions

Scientific Reports, 2021
Interestingly, some protein domains are intrinsically disordered (abbreviated as IDD), and the disorder degree of same domains may differ in different contexts.
Chao Gao, Chong Ma, Huqiang Wang, Haolin Zhong, Jiayin Zang, Rugang Zhong, Fuchu He, Dong Yang   +7 more
doaj   +1 more source

Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases [PDF]

, 2016
Purpose of review: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years.
Magalhães, Pedro, Mischak, Harald, Zürbig, Petra   +2 more
core   +1 more source

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

Nature Communications, 2019
Neutrophils and macrophages are both involved in the initiation of inflammation, but whether and how they may participate in inflammation resolution is unclear.
Wenting Yang, Yuandong Tao, Yan Wu, Xinyuan Zhao, Weijie Ye, Dianyuan Zhao, Ling Fu, Caiping Tian, Jing Yang, Fuchu He, Li Tang   +10 more
doaj   +1 more source

RIBAR and xRIBAR: methods for reproducible relative MS/MS-based label-free protein quantification [PDF]

, 2011
Mass spectrometry-driven proteomics is increasingly relying on quantitative analyses for biological discoveries. As a result, different methods and algorithms have been developed to perform relative or absolute quantification based on mass spectrometry ...
Colaert, Niklaas, Gevaert, Kris, Martens, Lennart   +2 more
core   +1 more source

A two-level model for the role of complex and young genes in the formation of organism complexity and new insights into the relationship between evolution and development

EvoDevo, 2018
Background How genome complexity affects organismal phenotypic complexity is a fundamental question in evolutionary developmental biology. Previous studies proposed various contributing factors of genome complexity and tried to find the connection ...
Dong Yang, Aishi Xu, Pan Shen, Chao Gao, Jiayin Zang, Chen Qiu, Hongsheng Ouyang, Ying Jiang, Fuchu He   +8 more
doaj   +1 more source

Defining the core proteome of the chloroplast envelope membranes [PDF]

, 2013
High-throughput protein localization studies require multiple strategies. Mass spectrometric analysis of defined cellular fractions is one of the complementary approaches to a diverse array of cell biological methods. In recent years, the protein content
Ibrahim, Mohamed, Karas, Michael, Leisegang, Matthias, Mirus, Oliver, Müller, Bernd, Papasotiriou, Dimitrios, Schleiff, Enrico, Schorge, Tobias, Simm, Stefan, Sommer, Maik Sascha   +9 more
core   +2 more sources

GIT2 deficiency attenuates concanavalin A‐induced hepatitis in mice

FEBS Open Bio, 2015
G protein‐coupled receptor kinase interactor 2 (GIT2) is a signaling scaffold protein involved in regulation of cytoskeletal dynamics and the internalization of G protein‐coupled receptors (GPCRs). The short‐splice form of GIT2 is expressed in peripheral
Yu-E Hao, Dong-Fang He, Rong-Hua Yin, Hui Chen, Jian Wang, Shao-Xia Wang, Yi-Qun Zhan, Chang-Hui Ge, Chang-Yan Li, Miao Yu, Xiao-Ming Yang   +10 more
doaj   +1 more source

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]

, 2014
The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart, Brewer, Heather M, Camp, David G, II, Depuydt, Geert, Petyuk, Vladislav A, Smith, Richard D, Smolders, Arne, Xie, Fang   +7 more
core   +2 more sources

The protein-protein interaction ontology: for better representing and capturing the biological context of protein interaction

BMC Genomics, 2021
Background With the rapid increase in the amount of Protein-Protein Interaction (PPI) data, the establishment of an event-centered PPI ontology that contains temporal and spatial vocabularies is urgently needed to clarify PPI biological annotations.
Mansheng Li, Qiang He, Chunyuan Yang, Jie Ma, Fuchu He, Tao Chen, Yunping Zhu   +6 more
doaj   +1 more source