Results 51 to 60 of about 461,354 (348)

Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions

Scientific Reports, 2021
Interestingly, some protein domains are intrinsically disordered (abbreviated as IDD), and the disorder degree of same domains may differ in different contexts.
Chao Gao, Chong Ma, Huqiang Wang, Haolin Zhong, Jiayin Zang, Rugang Zhong, Fuchu He, Dong Yang   +7 more
doaj   +1 more source

Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-PAINT [PDF]

, 2019
In the brain, the strength of each individual synapse is defined by the complement of proteins present or the "local proteome." Activity-dependent changes in synaptic strength are the result of changes in this local proteome and posttranslational protein
Böger, C., Endesfelder, U., Hafner, A., Heilemann, M., Jungmann, R., Malkusch, S., Schlichthärle, T., Schuman, E., Strauss, M.   +8 more
core   +2 more sources

Toward an understanding of the protein interaction network of the human liver

Molecular Systems Biology, 2011
Proteome‐scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery.
Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang   +37 more
doaj   +1 more source

OsteoporosAtlas: a human osteoporosis-related gene database [PDF]

PeerJ, 2019
Background Osteoporosis is a common, complex disease of bone with a strong heritable component, characterized by low bone mineral density, microarchitectural deterioration of bone tissue and an increased risk of fracture.
Xun Wang, Lihong Diao, Dezhi Sun, Dan Wang, Jiarun Zhu, Yangzhige He, Yuan Liu, Hao Xu, Yi Zhang, Jinying Liu, Yan Wang, Fuchu He, Yang Li, Dong Li   +13 more
doaj   +2 more sources

Oxidative stress response: a proteomic view [PDF]

Expert Rev Proteomics 2, 6 (2005) 949-56, 2008
The oxidative stress response is characterized by various effects on a range of biologic molecules. When examined at the protein level, both expression levels and protein modifications are altered by oxidative stress. While these effects have been studied in the past by classic biochemical methods, the recent onset of proteomics methods has allowed the
arxiv   +1 more source

Proteome Discoverer—A Community Enhanced Data Processing Suite for Protein Informatics

Proteomes, 2021
Proteomics researchers today face an interesting challenge: how to choose among the dozens of data processing and analysis pipelines available for converting tandem mass spectrometry files to protein identifications.
Benjamin C. Orsburn
semanticscholar   +1 more source

The Whereabouts of 2D Gels in Quantitative Proteomics [PDF]

Methods in Molecular Biology -Clifton then Totowa- 893 (2012) 25-35, 2012
Two-dimensional gel electrophoresis has been instrumental in the development of proteomics. Although it is no longer the exclusive scheme used for proteomics, its unique features make it a still highly valuable tool, especially when multiple quantitative comparisons of samples must be made, and even for large samples series.
arxiv   +1 more source

The proteostasis network and its decline in ageing

, 2019
Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Hartl, F., Hipp, M., Kasturi, P.
core   +1 more source

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

Nature Communications, 2019
Neutrophils and macrophages are both involved in the initiation of inflammation, but whether and how they may participate in inflammation resolution is unclear.
Wenting Yang, Yuandong Tao, Yan Wu, Xinyuan Zhao, Weijie Ye, Dianyuan Zhao, Ling Fu, Caiping Tian, Jing Yang, Fuchu He, Li Tang   +10 more
doaj   +1 more source

A two-level model for the role of complex and young genes in the formation of organism complexity and new insights into the relationship between evolution and development

EvoDevo, 2018
Background How genome complexity affects organismal phenotypic complexity is a fundamental question in evolutionary developmental biology. Previous studies proposed various contributing factors of genome complexity and tried to find the connection ...
Dong Yang, Aishi Xu, Pan Shen, Chao Gao, Jiayin Zang, Chen Qiu, Hongsheng Ouyang, Ying Jiang, Fuchu He   +8 more
doaj   +1 more source