Results 81 to 90 of about 538,471 (385)

Vibrio harveyi Infection Significantly Alters Amino Acid and Carbohydrate Metabolism in Whiteleg Shrimp, Litopenaeus vannamei

Metabolites, 2020
Vibrio harveyi is one of the pathogens that threaten the shrimp farming industry. However, metabolic changes induced by V. harveyi infection in shrimp remain unknown. In this study, we first conducted high resolution-magic angle spinning (HR-MAS) nuclear
Seohee Ma, Ahran Kim, Wonho Lee, Seonghye Kim, Sujin Lee, Dahye Yoon, Jin-Sol Bae, Chan-Il Park, Suhkmann Kim   +8 more
doaj   +1 more source

A model of large-scale proteome evolution [PDF]

, 2002
The next step in the understanding of the genome organization, after the determination of complete sequences, involves proteomics. The proteome includes the whole set of protein-protein interactions, and two recent independent studies have shown that its
Kepler, Thomas B., Pastor-Satorras, Romualdo, Smith, Eric, Sole, Ricard V.   +3 more
core   +3 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Vectorial Proteomics [PDF]

IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2005
Vectorial proteomics is a methodology for the differential identification and characterization of proteins and their domains exposed to the opposite sides of biological membranes. Proteomics of membrane vesicles from defined isolated membranes automatically determine cellular localization of the identified proteins and reduce complexity of protein ...
Alexander V, Vener, Peter, Strålfors
openaire   +2 more sources

Identification of functional gene modules by integrating multi-omics data and known molecular interactions

Frontiers in Genetics, 2023
Multi-omics data integration has emerged as a promising approach to identify patient subgroups. However, in terms of grouping genes (or gene products) into co-expression modules, data integration methods suffer from two main drawbacks.
Xiaoqing Chen, Xiaoqing Chen, Mingfei Han, Yingxing Li, Xiao Li, Jiaqi Zhang, Yunping Zhu, Yunping Zhu   +7 more
doaj   +1 more source

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma [PDF]

, 2011
In this work, the variations in the metabolic profile of blood plasma from lung cancer patients and healthy controls were investigated through NMR-based metabonomics, to assess the potential of this approach for lung cancer screening and diagnosis.
Ana Gomes, Ana M. Gil, António S. Barros, Asiago V. M., Bathe O. F., Bell J. D., Brian J. Goodfellow, Brière J.-J., Carrola J., Cláudia M. Rocha, Daykin C. A., Dong J., Duarte I. F., Duarte I. F., Erol A., Fan T. W. M., Fiorenza A. M., Fiorenza A. M., Freedman D. S., Gao H., Gao H. C., Gu H. W., Haffner H. T., Heber D., Iola F. Duarte, Isabel M. Carreira, Joana Carrola, João Bernardo, Jordan K. W., Keun H. C., Kochhar S., Lai H.-S., Laiakis E. C., Lin L., Lina Carvalho, Liu M., Lokhov P. G., Ludwig C., Ma Y., MacIntyre D. A., Maeda J., Muntoni S., Naini A. B., Norton J. A., Okamoto N., Pirozynski M., Psychogios N., Qiu Y. P., Ritchie S. A., Rocha C. M., Sitter B., Spratlin J. L., Sreekumar A., Stringer K. A., Thysell E., Tiziani S., Travis W. D., Trygg J., Urayama S., Vitor Sousa, Xu Q. S., Xue R., Yin P., Zhang J. A., Zhang Z. Y., Zhou J., Zira A. N.   +66 more
core   +2 more sources

Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome

bioRxiv, 2022
Single-cell Deep Visual Proteomics integrates imaging, cell segmentation, laser microdissection and multiplexed mass spectrometry for spatial single-cell proteomics measurements in complex tissues.
Florian A. Rosenberger, Marvin Thielert, Maximilian T. Strauss, Constantin Ammar, Sophia C. Mädler, L. Schweizer, Andreas Metousis, Patricia Skowronek, Maria Wahle, Janine Gote-Schniering, Anna Semenova, H. Schiller, Edwin H. Rodriguez, T. Nordmann, A. Mund, Matthias Mann   +15 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Simulated digestions of free oligosaccharides and mucin-type O-glycans reveal a potential role for Clostridium perfringens

Scientific Reports
The development of a stable human gut microbiota occurs within the first year of life. Many open questions remain about how microfloral species are influenced by the composition of milk, in particular its content of human milk oligosaccharides (HMOs ...
Andrew G. McDonald, Frédérique Lisacek
doaj   +1 more source

COVID‐19 diagnostic testing: Technology perspective

Clinical and Translational Medicine, 2020
The corona virus disease 2019 (COVID‐19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
Meng Xu, Dan Wang, Hongye Wang, Xiaomei Zhang, Te Liang, Jiayu Dai, Meng Li, Jiahui Zhang, Kai Zhang, Danke Xu, Xiaobo Yu   +10 more
doaj   +1 more source