Results 81 to 90 of about 461,354 (348)

Pathway analysis and transcriptomics improve protein identification by shotgun proteomics from samples comprising small number of cells - a benchmarking study [PDF]

, 2014
BACKGROUND: Proteomics research is enabled with the high-throughput technologies, but our ability to identify expressed proteome is limited in small samples. The coverage and consistency of proteome expression are critical problems in proteomics.
Brusic, Vladimir, Fenyo, David, Ivanov, Alexander R., Karger, Barry L., Li, Siyang, Lisacek, Frederique, Murthy, Shashi K., Sun, Jing, Zhang, Guang Lan   +8 more
core   +5 more sources

Nanotechnologies in Proteomics [PDF]

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Victor A. Bykov, Vadim M. Govorun, Alexander I. Archakov, Yuri D. Ivanov   +3 more
openaire   +4 more sources

Experimental Measurements and Mathematical Modeling of Cytosolic Ca2+ Signatures upon Elicitation by Penta-N-acetylchitopentaose Oligosaccharides in Nicotiana tabacum Cell Cultures

Plants, 2013
Plants have developed sophisticated recognition systems for different kinds of pathogens. Pathogen-associated molecular patterns (PAMPs) can induce various defense mechanisms, e.g., the production of reactive oxygen species (ROS) as an early event. Plant
Kalina Mrozek, Karsten Niehaus, Petra Lutter   +2 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Toll-like receptor 5-mediated signaling enhances liver regeneration in mice

Military Medical Research, 2021
Background Toll-like receptor 5 (TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic diseases.
Wen Zhang, Lei Wang, Xue-Hua Sun, Xian Liu, Yang Xiao, Jie Zhang, Ting Wang, Hui Chen, Yi-Qun Zhan, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Guang-Ming Ren, Rong-Hua Yin, Xiao-Ming Yang   +14 more
doaj   +1 more source

Undulating changes in human plasma proteome profiles across the lifespan

Nature Network Boston, 2019
Aging is a predominant risk factor for several chronic diseases that limit healthspan1. Mechanisms of aging are thus increasingly recognized as potential therapeutic targets.
B. Lehallier, D. Gate, N. Schaum, T. Nánási, S. Lee, H. Yousef, Patricia Moran Losada, D. Berdnik, A. Keller, J. Verghese, Sanish Sathyan, C. Franceschi, S. Milman, N. Barzilai, T. Wyss-Coray   +14 more
semanticscholar   +1 more source

Increasing cell size remodels the proteome and promotes senescence

bioRxiv, 2021
Cell size is tightly controlled in healthy tissues, but it is poorly understood how variations in cell size affect cell physiology. To address this, we employed a high-accuracy mass spectrometry-based approach to measure how the proteome changes with ...
Michael C. Lanz, E. Zatulovskiy, Matthew P. Swaffer, Lichao Zhang, Ilayda Ilerten, Shuyuan Zhang, D. You, G. Marinov, Patrick L. McAlpine, Josh E. Elias, J. Skotheim   +10 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

A List of Candidate Cancer Biomarkers for Targeted Proteomics

Biomarker Insights, 2006
We have compiled from literature and other sources a list of 1261 proteins believed to be differentially expressed in human cancer. These proteins, only some of which have been detected in plasma to date, represent a population of candidate plasma ...
Malu Polanski, N. Leigh Anderson
doaj   +1 more source

Pancreatic cancer cells spectral library by DIA-MS and the phenotype analysis of gemcitabine sensitivity

Scientific Data, 2022
Measurement(s) protein expression profiling Technology Type(s) Mass ...
Ran Kong, Xiaohong Qian, Wantao Ying
doaj   +1 more source