Results 51 to 60 of about 22,304,287 (299)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Multicentric validation of proteomic biomarkers in urine specific for diabetic nephropathy [PDF]

, 2010
Background: Urine proteome analysis is rapidly emerging as a tool for diagnosis and prognosis in disease states. For diagnosis of diabetic nephropathy (DN), urinary proteome analysis was successfully applied in a pilot study.
Navis, G.J., Zürbig, P., Fuchs, S., Winklhofer-Roob, B.M., Cerna Marie, Rossing Peter, Federici, M., Bakker Stephan J. L., Fischer Christine, Bakker, Stephan J. L.; id_orcid, Fuchs Sebastian, Zurbig, Petra, Rychlik, Ivan, Rychlík, I., Karel Medek, Navis, Gerjan J., Fischer, Christine, Cerna, Marie, Rossing, K., Gerjan J. Navis, Mischak Harald, Sebastian Fuchs, Stephan J L Bakker, Bilo Henk J. G., Mischak, H., Kasper Rossing, Medek, K., Rossing Kasper, PREDICTIONS Group, Bilo, H.J.G., Medek, Karel, null null, Fischer, C., Johannes M. Roob, Roob Johannes M., Alkhalaf, A., Mischak, Harald, Cerna, M., Janssen, Bart, Fuchs, Sebastian, Bakker, S.J.L., Johannes M Roob, Alaa Alkhalaf, Janssen, B., Bakker, Stephan J. L., Ivan Rychlík, Brigitte M. Winklhofer-Roob, Tiran, Beate, Rychlík Ivan, Roob, Johannes M., Zürbig Petra, Sourij, H., Tiran Beate, Bilo, Henk J. G., Rossing, Peter, Sourij Harald, Winklhofer-Roob, Brigitte M., Navis Gerjan J., Gerjan J Navis, Marie Cerna, Alkhalaf, Alaa, Henk J G Bilo, Christine Fischer, Petra Zürbig, Janssen Bart, Peter Rossing, Bart Janssen, Henk J. G. Bilo, Alkhalaf Alaa, Medek Karel, Harald Mischak, Stephan J. L. Bakker, Tiran, B., Rossing, P., Brigitte M Winklhofer-Roob, Sourij, Harald, Rossing, Kasper, Roob, J.M., Harald Sourij, Beate Tiran, Winklhofer-Roob Brigitte M.   +80 more
core   +3 more sources

Antibacterial Activity and Multi-Targeted Mechanism of Action of Suberanilic Acid Isolated from Pestalotiopsis trachycarpicola DCL44: An Endophytic Fungi from Ageratina adenophora

Molecules
Methicillin-resistant Staphylococcus aureus (MRSA) is a highly threatening foodborne pathogen capable of causing severe organ and life-threatening diseases.
Juan Wen, Samuel Kumi Okyere, Shu Wang, Jianchen Wang, Ruya Huang, Ziyao Tang, Xiaoxuan Wang, Chenyang Shao, Yanchun Hu   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effects of Cannabidiol Oil on Anesthetic Requirements in Cats: MAC Determination and Serum Profiling via Nanoscale Liquid Chromatography–Tandem Mass Spectrometry

Animals
Cannabidiol (CBD), a non-psychotropic cannabinoid derived from Cannabis plants, is increasingly explored for its potential therapeutic applications in veterinary medicine.
Panisara Suriyawongpongsa, Sirirat Niyom, Kannika Wanapinit, Monchanok Vijarnsorn, Sittiruk Roytrakul, Sekkarin Ploypetch   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Proteomic candidate biomarkers of drug-induced nephrotoxicity in the rat [PDF]

, 2012
Improved biomarkers of acute nephrotoxicity are coveted by the drug development industry, regulatory agencies, and clinicians. In an effort to identify such biomarkers, urinary peptide profiles of rats treated with two different nephrotoxins were ...
Hanig, J., Mischak, H., Harald Mischak (103627), Rouse Rodney, Mullen, W., Metzger, J., William Mullen (103621), Rodney Rouse, William Mullen, Jochen Metzger, Jochen Metzger (171762), Hanig Joseph, Siwy, J., Joseph Hanig, Justyna Siwy (103595), Mullen William, Harald Mischak, Rouse, R., Justyna Siwy, Rodney Rouse (171753), Metzger Jochen, Joseph Hanig (82484), Siwy Justyna, Mischak Harald   +23 more
core   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source