Results 51 to 60 of about 428,393 (307)

Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]

, 2015
Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F, Andrew K Ottens, Bales JW, Begum G, Berger RP, Bonislawski DP, Bos R, Boulenguez P, Boutte AM, Brandner S, Brandner S, Campos-Martorell M, Cortes DF, Crawford F, Dachir S, Daoud H, Evans TM, Gackiere F, Gonzalez MI, Guingab-Cagmat JD, Gyorgy A, Gyorgy AB, Jaramillo ML, Jeter CB, Kabadi SV, Kabadi SV, Kahle KT, Kumar A, Levi S, Li BC, Liang J, Liang J, Lin WM, Loane DJ, Loov C, Lopez NE, Maier O, Manley GT, Maurer MH, Mehan ND, Mohseni S, Mondello S, Mondello S, Ottens AK, Ottens AK, Pavel N Lizhnyak, Prieto DA, Rau TF, Rosenfeld JV, Saatman KE, Schmid KE, Shen S, Shen Y, Siman R, Siman R, Sun C, Talley Watts L, Tsai YT, Wagner AK, Wu P, Xiong Y, Yu W, Zetterberg H, Zgavc T, Zhou XM   +64 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Pathway analysis and transcriptomics improve protein identification by shotgun proteomics from samples comprising small number of cells - a benchmarking study [PDF]

, 2014
BACKGROUND: Proteomics research is enabled with the high-throughput technologies, but our ability to identify expressed proteome is limited in small samples. The coverage and consistency of proteome expression are critical problems in proteomics.
Brusic, Vladimir, Fenyo, David, Ivanov, Alexander R., Karger, Barry L., Li, Siyang, Lisacek, Frederique, Murthy, Shashi K., Sun, Jing, Zhang, Guang Lan   +8 more
core   +12 more sources

The RpoS Sigma Factor Negatively Regulates Production of IAA and Siderophore in a Biocontrol Rhizobacterium, Pseudomonas chlororaphis O6

The Plant Pathology Journal, 2013
The stationary-phase sigma factor, RpoS, influences the expression of factors important in survival of Pseudomonas chlororaphis O6 in the rhizosphere. A partial proteomic profile of a rpoS mutant in P.
Sang A Oh, Ji Soo Kim, Ju Yeon Park, Song Hee Han, Christian Dimkpa, Anne J. Anderson, Young Cheol Kim   +6 more
doaj   +1 more source

Heat Adaptation Induced Cross Protection Against Ethanol Stress in Tetragenococcus halophilus: Physiological Characteristics and Proteomic Analysis

Frontiers in Microbiology, 2021
Ethanol is a toxic factor that damages membranes, disturbs metabolism, and may kill the cell. Tetragenococcus halophilus, considered as the cell factory during the manufacture of traditional fermented foods, encounters ethanol stress, which may affect ...
Huan Yang, Huan Yang, Shangjie Yao, Shangjie Yao, Min Zhang, Min Zhang, Chongde Wu, Chongde Wu   +7 more
doaj   +1 more source

Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure. [PDF]

, 2018
Acute exposure to high concentrations of H2S causes severe brain injury and long-term neurological disorders, but the mechanisms involved are not known.
Anantharam, Poojya, Gearhart, Jeffery M, Grobe, Nadja, Hoffmann, Andrea, Kim, Dong-Suk, Mahama, Belinda, Meade, Mitchell L, Rumbeiha, Wilson K, Whitley, Elizabeth M   +8 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib. [PDF]

, 2018
BackgroundEarly detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development.
DeLisle, Robert K, Ganz, Peter, Hyde, Craig, Malarstig, Anders, Murthy, Ashwin C, Ostroff, Rachel, Segal, Mark R, Weiss, Sophie J, Williams, Stephen A   +8 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source