Results 91 to 100 of about 784,733 (395)

Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis

Nature Communications, 2018
Microtubule asters originate from centrosomes but their role during interphase remains largely unknown. Here, the authors find that microtubule asters anchored by previously-uncharacterized FSD1 play a role in ciliogenesis by maintaining the dynamic ...
Hai-Qing Tu, Xuan-He Qin, Zhi-Bin Liu, Zeng-Qing Song, Huai-Bin Hu, Yu-Cheng Zhang, Yan Chang, Min Wu, Yan Huang, Yun-Feng Bai, Guang Wang, Qiu-Ying Han, Ai-Ling Li, Tao Zhou, Feng Liu, Xue-Min Zhang, Hui-Yan Li   +16 more
doaj   +1 more source

Identifying individuals using proteomics: are we there yet?

Frontiers in Molecular Biosciences, 2022
Multi-omics approaches including proteomics analyses are becoming an integral component of precision medicine. As clinical proteomics studies gain momentum and their sensitivity increases, research on identifying individuals based on their proteomics ...
Ivo Fierro-Monti, James C. Wright, Jyoti S. Choudhary, Juan Antonio Vizcaíno   +3 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Sialic acid linkage differentiation of glycopeptides using capillary electrophoresis – electrospray ionization – mass spectrometry

Scientific Reports, 2017
Sialylation is a glycosylation feature that occurs in different linkages at the non-reducing end of a glycan moiety, the linkage isomers are often differentially associated with various biological processes.
Guinevere S. M. Kammeijer, Bas C. Jansen, Isabelle Kohler, Anthonius A. M. Heemskerk, Oleg A. Mayboroda, Paul J. Hensbergen, Julie Schappler, Manfred Wuhrer   +7 more
doaj   +1 more source

A Direct MS-Based Approach to Profile Human Milk Secretory Immunoglobulin A (IgA1) Reveals Donor-Specific Clonal Repertoires With High Longitudinal Stability

Frontiers in Immunology, 2021
Recently, a mass spectrometry-based approach was introduced to directly assess the IgG1 immunoglobulin clonal repertoires in plasma. Here we expanded upon this approach by describing a mass spectrometry-based technique to assess specifically the clonal ...
Albert Bondt, Albert Bondt, Kelly A. Dingess, Kelly A. Dingess, Max Hoek, Max Hoek, Danique M. H. van Rijswijck, Danique M. H. van Rijswijck, Albert J. R. Heck, Albert J. R. Heck   +9 more
doaj   +1 more source

Stable isotopic labeling in proteomics [PDF]

, 2008
Labeling of proteins and peptides with stable heavy isotopes (deuterium, carbon-13, nitrogen-15, and oxygen-18) is widely used in quantitative proteomics.
Beynon, Blagoev, Borisov, Browder, Choe, Conrads, Craig, de Godoy, De Leenheer, Dean, Desiderio, Enoksson, Gerber, Gevaert, Gevaert, Gevaert, Gevaert, Gevaert, Gonzalez, Gronborg, Gruhler, Gygi, Hansen, Harsha, Hsu, Hsu, Hsu, Impens, Ji, Krijgsveld, Kuster, Kuster, Lange, Lanquar, Lopez-Otin, MacCoss, Mann, Mason, Mirzaei, Munchbach, Oda, Ong, Ong, Overall, Pan, Perkins, Pratt, Rivers, Ross, Schmidt, Schnolzer, Schulze, Scott, Selbach, Sethuraman, Staes, Staes, Tam, Van Damme, Van Hoof, Vande Walle, Wahlander, Wang, Washburn, Wiese, Wu, Zhang, Zhang, Zhang, Zhou   +69 more
core   +2 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

MSFragger: ultrafast and comprehensive peptide identification in shotgun proteomics

Nature Methods, 2017
There is a need to better understand and handle the 'dark matter' of proteomics—the vast diversity of post-translational and chemical modifications that are unaccounted in a typical mass spectrometry–based analysis and thus remain unidentified.
Andy T. Kong, F. V. Leprevost, D. Avtonomov, Dattatreya Mellacheruvu, A. Nesvizhskii   +4 more
semanticscholar   +1 more source

Proteomics-on-a-chip for Biomarker discovery [PDF]

, 2007
In proteomics research still two-dimensional gel electrophoresis (2D-GE) is currently used for biomarker discovery. We applied free flow electrophoresis (FFE) separation technology combined with biomolecular interaction sensing using Surface Plasmon ...
Berg, Albert van den, Eijkel, Jan, Kohlheyer, Dietrich, Schasfoort, Richard B.M., Schlautmann, Stefan   +4 more
core   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source