Results 51 to 60 of about 505,018 (335)

Foresight in clinical proteomics: current status, ethical considerations, and future perspectives [version 2; peer review: 3 approved]

Open Research Europe, 2023
With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research.
Filip Mundt, Sebastian Porsdam Mann, Nicolai J. Wewer Albrechtsen, Medini Ghodgaonkar-Steger, Peter Treit, Reinout Raijmakers, Martina O’Flaherty, Albert J.R. Heck, Juan Antonio Vizcaíno, Matthias Mann   +9 more
doaj  

Precise diagnosis and typing of early-stage renal immunoglobulin-derived amyloidosis by label-free quantification of parallel reaction monitoring-based targeted proteomics

BMC Nephrology, 2023
Background Early diagnosis and typing are crucial for improving the prognosis of patients with renal amyloidosis. Currently, Untargeted proteomics based precise diagnosis and typing of amyloid deposits are crucial for guiding patient management. Although
Yuan Li, Ying Zhang, Xinjin Zhou, Xinli Xue, Muxi Wang, Dedong Kang, Yali Zhou, Ruimin Hu, Songxia Quan, Guolan Xing, Jinghua Yang   +10 more
doaj   +1 more source

Proteomics: Concepts and applications in human medicine

World Journal of Biological Chemsitry, 2021
Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell.
Safa Al-Amrani, Zaaima Al-Jabri, A. Al-Zaabi, J. Alshekaili, M. Al-Khabori   +4 more
semanticscholar   +1 more source

Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery

Frontiers in Medicine, 2021
Proteomics has become an important field in molecular sciences, as it provides valuable information on the identity, expression levels, and modification of proteins. For example, cancer proteomics unraveled key information in mechanistic studies on tumor
Yang Woo Kwon, Han-Seul Jo, Sungwon Bae, Youngsuk Seo, Parkyong Song, Minseok Song, J. Yoon   +6 more
semanticscholar   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Application of a validated prognostic plasma protein biomarker test for renal decline in type 2 diabetes to type 1 diabetes: the Fremantle Diabetes Study Phase II

Clinical Diabetes and Endocrinology
Background There are scant data relating to prognostic biomarkers for chronic kidney disease (CKD) complicating type 1 diabetes. The aim of this study was to assess the performance of the plasma protein biomarker-based PromarkerD test developed and ...
Timothy M. E. Davis, Wendy A. Davis, Scott D. Bringans, James K. C. Lui, Tasha S. C. Lumbantobing, Kirsten E. Peters, Richard J. Lipscombe   +6 more
doaj   +1 more source

Human pituitary adenoma proteomics: new progresses and perspectives

Frontiers in Endocrinology, 2016
Pituitary adenoma (PA) is a commonly intracranial neoplasm that impacts on human health through interfering hypothalamus-pituitary-target organ axis systems. The development of proteomics gives great promises in clarification of molecular mechanisms of a
Xianquan eZhan, Xiaowei eWang, Tingting eCheng   +2 more
doaj   +1 more source

The Endogenous Metabolite Glycerophosphocholine Promotes Longevity and Fitness in Caenorhabditis elegans

Metabolites, 2022
Metabolism and aging are closely connected. The choline derivative glycerophosphocholine (GPC), an important precursor of the neurotransmitter acetylcholine, plays important roles in brain and nervous system function.
Jia-Yu Liu, Run-Qi Zheng, Yao Wang, Yan-Hong Liu, Shuai Jiang, Xin-Zheng Wang, Kun He, Xin Pan, Tao Zhou, Tao Li, Qing Xia, Wei-Na Zhang   +11 more
doaj   +1 more source

The ProteomeXchange consortium in 2020: enabling ‘big data’ approaches in proteomics

Nucleic Acids Res., 2019
The ProteomeXchange (PX) consortium of proteomics resources (http://www.proteomexchange.org) has standardized data submission and dissemination of mass spectrometry proteomics data worldwide since 2012.
E. Deutsch, N. Bandeira, Vagisha Sharma, Yasset Pérez-Riverol, Jeremy J. Carver, D. J. Kundu, D. García-Seisdedos, Andrew F. Jarnuczak, Suresh Hewapathirana, B. Pullman, J. Wertz, Zhi Sun, S. Kawano, Shujiro Okuda, Yu Watanabe, H. Hermjakob, B. MacLean, M. MacCoss, Yun-ping Zhu, Y. Ishihama, J. Vizcaíno   +20 more
semanticscholar   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source