Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases [PDF]
, 2016 Purpose of review: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years.
Magalhães, Pedro +2 more
core +1 more source
Two-dimensional gel electrophoresis in proteomics: past, present and future [PDF]
Journal of proteomics (2010) epub ahead of print, 2010 Two-dimensional gel electrophoresis has been instrumental in the birth and developments of proteomics, although it is no longer the exclusive separation tool used in the field of proteomics. In this review, a historical perspective is made, starting from the days where two-dimensional gels were used and the word proteomics did not even exist.
arxiv +1 more source
A Cross-platform Toolkit for Mass Spectrometry and Proteomics
Nature Biotechnology, 2012 Mass-spectrometry-based proteomics has become an important component of biological research. Numerous proteomics methods have been developed to identify and quantify the proteins in biological and clinical samples1, identify pathways affected by ...
Matthew Chambers +42 more
semanticscholar +1 more source
, 2012 Chemical cross-linking in combination with mass spectrometric analysis offers the potential to obtain low-resolution structural information from proteins and protein complexes. Identification of peptides connected by a cross-link provides direct evidence
Aebersold, R. +6 more
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ProteomeXchange provides globally co-ordinated proteomics data submission and dissemination
Nature Biotechnology, 2014 223 12. Li, G.-Z. et al. Proteomics 9, 1696–1719 (2009). 13. Blackburn, K., Mbeunkui, F., Mitra, S.K., Mentzel, T. & Goshe, M.B. J. Proteome Res. 9, 3621–3637 (2010). 14. Huang, X. et al. Anal. Chem. 83, 6971–6979 (2011). 15. Geiger, T., Cox, J.
J. Vizcaíno +24 more
semanticscholar +1 more source
Bioinformatics Approach for Functional Glycomics [PDF]
, 2007 Presentation in the Human Glycomics Proteomics Disease Initiative (HGPI ...
James C. Paulson
core +2 more sources
An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes. [PDF]
, 2018 Mass spectrometry (MS) has become a crucial technique for the analysis of protein complexes. Native MS has traditionally examined protein subunit arrangements, while proteomics MS has focused on sequence identification.
Campuzano, Iain DG +4 more
core +1 more source
Highly sensitive CE-ESI-MS analysis of N-glycans from complex biological samples
Nature Communications, 2019 In-depth characterization of complex glycomes is complicated by the immense structural diversity of glycans. Here, the authors present a mass spectrometry-based strategy for untargeted, sensitive glycan profiling and identify 167 N-glycan compositions in
Guinevere S. M. Lageveen-Kammeijer +7 more
doaj +1 more source
Mass-spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation [PDF]
Genome Biology, 2018, 2018 Cellular heterogeneity is important to biological processes, including cancer and development. However, proteome heterogeneity is largely unexplored because of the limitations of existing methods for quantifying protein levels in single cells. To alleviate these limitations, we developed Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS), and ...
arxiv +1 more source
Proceedings of the EuBIC Winter School 2019 [PDF]
, 2019 The 2019 European Bioinformatics Community (EuBIC) Winter School was held from January 15th to January 18th 2019 in Zakopane, Poland. This year’s meeting was the third of its kind and gathered international researchers in the field of (computational ...
Bittremieux, Wout +9 more
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