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Progress in the definition of a reference human mitochondrial proteome [PDF]
Proteomics 3 (02/2003) 157-67, 2006 Owing to the complexity of higher eukaryotic cells, a complete proteome is likely to be very difficult to achieve. However, advantage can be taken of the cell compartmentalization to build organelle proteomes, which can moreover be viewed as specialized tools to study specifically the biology and "physiology" of the target organelle. Within this frame,
arxiv +1 more source
ISPIDER Central: an integrated database web-server for proteomics [PDF]
, 2008 Despite the growing volumes of proteomic data, integration of the underlying results remains problematic owing to differences in formats, data captured, protein accessions and services available from the individual repositories.
Belhajjame, K. +17 more
core +2 more sources
Paleoproteomics explained to youngsters: how did the wedding of two-dimensional electrophoresis and protein sequencing spark proteomics on: Let there be light [PDF]
Journal of Proteomics 107C (2014) 5-12, 2014 Taking the opportunity of the 20th anniversary of the word "proteomics", this young adult age is a good time to remember how proteomics came from enormous progress in protein separation and protein microanalysis techniques, and from the conjugation of these advances into a high performance and streamlined working setup.
arxiv +1 more source
Membrane proteins and proteomics: Love is possible, but so difficult [PDF]
, 2009 Despite decades of extensive research, the large-scale analysis of membrane proteins remains a difficult task. This is due to the fact that membrane proteins require a carefully balanced hydrophilic and lipophilic environment, which optimum varies with ...
Adessi +103 more
core +4 more sources
Open Research Europe, 2023 With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research.
Filip Mundt +9 more
doaj
The Plasmodium falciparum artemisinin susceptibility-associated AP-2 adaptin mu subunit is clathrin-independent and essential for schizont-maturation v2.0 [PDF]
, 2020 Proteomics datasets, presented as a set of tables, produced as part of Dr Ryan Henrici's PhD project (completed 2018).
Henrici, Ryan, Sutherland, Colin
core +1 more source
Combining LOPIT with differential ultracentrifugation for high-resolution spatial proteomics
Nature Communications, 2019 Spatial proteomics allows studying cellular protein localisations at system-wide scale. Here, the authors show that combining the previously developed hyperLOPIT method with differential centrifugation yields protein localisation maps at suborganellar ...
Aikaterini Geladaki +8 more
doaj +1 more source
Oxidative stress response: a proteomic view [PDF]
Expert Rev Proteomics 2, 6 (2005) 949-56, 2008 The oxidative stress response is characterized by various effects on a range of biologic molecules. When examined at the protein level, both expression levels and protein modifications are altered by oxidative stress. While these effects have been studied in the past by classic biochemical methods, the recent onset of proteomics methods has allowed the
arxiv +1 more source
Journal of the American Society for Mass Spectrometry, 2021 Biological systems are composed of heterogeneous populations of cells that intercommunicate to form a functional living tissue. Biological function varies greatly across populations of cells, as each single cell has a unique transcriptome, proteome, and ...
Michael J Taylor +2 more
semanticscholar +1 more source
BMC Nephrology, 2023 Background Early diagnosis and typing are crucial for improving the prognosis of patients with renal amyloidosis. Currently, Untargeted proteomics based precise diagnosis and typing of amyloid deposits are crucial for guiding patient management. Although
Yuan Li +10 more
doaj +1 more source