Results 61 to 70 of about 490,947 (358)

The ProteomeXchange consortium in 2020: enabling ‘big data’ approaches in proteomics

Nucleic Acids Res., 2019
The ProteomeXchange (PX) consortium of proteomics resources (http://www.proteomexchange.org) has standardized data submission and dissemination of mass spectrometry proteomics data worldwide since 2012.
E. Deutsch, N. Bandeira, Vagisha Sharma, Yasset Pérez-Riverol, Jeremy J. Carver, D. J. Kundu, D. García-Seisdedos, Andrew F. Jarnuczak, Suresh Hewapathirana, B. Pullman, J. Wertz, Zhi Sun, S. Kawano, Shujiro Okuda, Yu Watanabe, H. Hermjakob, B. MacLean, M. MacCoss, Yun-ping Zhu, Y. Ishihama, J. Vizcaíno   +20 more
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Application of a validated prognostic plasma protein biomarker test for renal decline in type 2 diabetes to type 1 diabetes: the Fremantle Diabetes Study Phase II

Clinical Diabetes and Endocrinology
Background There are scant data relating to prognostic biomarkers for chronic kidney disease (CKD) complicating type 1 diabetes. The aim of this study was to assess the performance of the plasma protein biomarker-based PromarkerD test developed and ...
Timothy M. E. Davis, Wendy A. Davis, Scott D. Bringans, James K. C. Lui, Tasha S. C. Lumbantobing, Kirsten E. Peters, Richard J. Lipscombe   +6 more
doaj   +1 more source

Two-dimensional gel electrophoresis in proteomics: A tutorial [PDF]

Journal of Proteomics 74, 10 (2011) 1829-41, 2011
Two-dimensional electrophoresis of proteins has preceded, and accompanied, the birth of proteomics. Although it is no longer the only experimental scheme used in modern proteomics, it still has distinct features and advantages. The purpose of this tutorial paper is to guide the reader through the history of the field, then through the main steps of the
arxiv   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Sialic acid linkage differentiation of glycopeptides using capillary electrophoresis – electrospray ionization – mass spectrometry

Scientific Reports, 2017
Sialylation is a glycosylation feature that occurs in different linkages at the non-reducing end of a glycan moiety, the linkage isomers are often differentially associated with various biological processes.
Guinevere S. M. Kammeijer, Bas C. Jansen, Isabelle Kohler, Anthonius A. M. Heemskerk, Oleg A. Mayboroda, Paul J. Hensbergen, Julie Schappler, Manfred Wuhrer   +7 more
doaj   +1 more source

Precise diagnosis and typing of early-stage renal immunoglobulin-derived amyloidosis by label-free quantification of parallel reaction monitoring-based targeted proteomics

BMC Nephrology, 2023
Background Early diagnosis and typing are crucial for improving the prognosis of patients with renal amyloidosis. Currently, Untargeted proteomics based precise diagnosis and typing of amyloid deposits are crucial for guiding patient management. Although
Yuan Li, Ying Zhang, Xinjin Zhou, Xinli Xue, Muxi Wang, Dedong Kang, Yali Zhou, Ruimin Hu, Songxia Quan, Guolan Xing, Jinghua Yang   +10 more
doaj   +1 more source

A Direct MS-Based Approach to Profile Human Milk Secretory Immunoglobulin A (IgA1) Reveals Donor-Specific Clonal Repertoires With High Longitudinal Stability

Frontiers in Immunology, 2021
Recently, a mass spectrometry-based approach was introduced to directly assess the IgG1 immunoglobulin clonal repertoires in plasma. Here we expanded upon this approach by describing a mass spectrometry-based technique to assess specifically the clonal ...
Albert Bondt, Albert Bondt, Kelly A. Dingess, Kelly A. Dingess, Max Hoek, Max Hoek, Danique M. H. van Rijswijck, Danique M. H. van Rijswijck, Albert J. R. Heck, Albert J. R. Heck   +9 more
doaj   +1 more source

Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery

Frontiers in Medicine, 2021
Proteomics has become an important field in molecular sciences, as it provides valuable information on the identity, expression levels, and modification of proteins. For example, cancer proteomics unraveled key information in mechanistic studies on tumor
Yang Woo Kwon, Han-Seul Jo, Sungwon Bae, Youngsuk Seo, Parkyong Song, Minseok Song, J. Yoon   +6 more
semanticscholar   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source