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The Whereabouts of 2D Gels in Quantitative Proteomics [PDF]
Methods in Molecular Biology -Clifton then Totowa- 893 (2012)
25-35, 2012 Two-dimensional gel electrophoresis has been instrumental in the development of proteomics. Although it is no longer the exclusive scheme used for proteomics, its unique features make it a still highly valuable tool, especially when multiple quantitative comparisons of samples must be made, and even for large samples series.
arxiv +1 more source
Open Research Europe, 2023 With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research.
Filip Mundt +9 more
doaj
Using R and Bioconductor for proteomics data analysis [PDF]
Biochim Biophys Acta. 1844 (2014) 1844 42-51, 2013 This review presents how R, the popular statistical environment and programming language, can be used in the frame of proteomics data analysis. A short introduction to R is given, with special emphasis on some of the features that make R and its add-on packages a premium software for sound and reproducible data analysis.
arxiv +1 more source
Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling [PDF]
, 2014 <b>Background:</b> Proteomics-based approaches for biomarker discovery are promising strategies used in cancer research. We present state-of-art label-free quantitative proteomics method to assess proteome of renal cell carcinoma (RCC ...
Atrih, A. +8 more
core +3 more sources
Proteomics Characterization of Extracellular Space Components in the Human Aorta [PDF]
, 2010 The vascular extracellular matrix (ECM) is essential for the structural integrity of the vessel wall and also serves as a substrate for the binding and retention of secreted products of vascular cells as well as molecules coming from the circulation ...
Bregant +40 more
core +2 more sources
Metabolites, 2022 Metabolism and aging are closely connected. The choline derivative glycerophosphocholine (GPC), an important precursor of the neurotransmitter acetylcholine, plays important roles in brain and nervous system function.
Jia-Yu Liu +11 more
doaj +1 more source
Comprehensive Overview of Bottom-up Proteomics using Mass Spectrometry [PDF]
arXiv, 2023 Proteomics is the large scale study of protein structure and function from biological systems through protein identification and quantification. "Shotgun proteomics" or "bottom-up proteomics" is the prevailing strategy, in which proteins are hydrolyzed into peptides that are analyzed by mass spectrometry.
arxiv
The proteomic to biology inference, a frequently overlooked concern in the interpretation of proteomic data: A plea for functional validation [PDF]
PROTEOMICS 14, 2-3 (2014) 157-61, 2014 Proteomics will celebrate its 20th year in 2014. In this relatively short period of time, it has invaded most areas of biology and its use will probably continue to spread in the future. These two decades have seen a considerable increase in the speed and sensitivity of protein identification and characterization, even from complex samples.
arxiv +1 more source
Proteomics: Concepts and applications in human medicine
World Journal of Biological Chemsitry, 2021 Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell.
Safa Al-Amrani +4 more
semanticscholar +1 more source
Multiplierz: An Extensible API Based Desktop Environment for Proteomics Data Analysis [PDF]
, 2009 BACKGROUND. Efficient analysis of results from mass spectrometry-based proteomics experiments requires access to disparate data types, including native mass spectrometry files, output from algorithms that assign peptide sequence to MS/MS spectra, and ...
Askenazi, Manor +7 more
core +4 more sources