Results 241 to 250 of about 62,588 (334)

Editorial: Brain aging, neurodegeneration, and the role of natural molecules in maintaining brain health. [PDF]

Front Neurosci
Kujawska M, Kreiner G, Teissedre PL.
europepmc   +1 more source

Hematopoietic Stem Cells Require Elevated Protein Quality Control [PDF]

, 2018
Dillingham, Christopher, Hatters, Danny, Hong, Yuning, Kruta, Miriama, San Jose, Lorena Hidalgo, Signer, Robert, Sunshine, Mary Jean   +6 more
core  

ROC‐325 Attenuates Hypoxia‐Induced Pulmonary Hypertension Through Dual Inhibition of Autophagy and Hypoxia‐Inducible Factor 2α Signaling

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
In hypoxia‐induced pulmonary hypertension, endothelial HIF‐2α accumulation and autophagic activation drive vascular remodeling. We demonstrate that the novel lysosomal inhibitor ROC‐325 simultaneously attenuates this pathogenic autophagy and promotes HIF‐2α degradation.
Changlei Bao, Shuxin Liang, Dingyuan Liu, Xingting Wang, Dan Bai, Chuangjia Huang, Hanliang Sun, Zi Yang, Bitao Wu, Zixuan Chen, Jieyi Feng, Zinan Luo, Jintao Long, Jinsheng Zhu, June Bai, Li Zhang, Aiai Chu, Caojin Zhang, Haiyang Tang   +18 more
wiley   +1 more source

In and out of the mitochondrial intermembrane space

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Mitochondria are essential organelles constituted by two membranes, the outer (OMM) and inner mitochondrial membrane (IMM), and two aqueous compartments, the intermembrane space (IMS) and the matrix. Although mitochondria contain their own genome, which encodes for 13 proteins in humans (8 in budding yeast), the vast majority (99%) of ...
Fara van der Schans, Kostas Tokatlidis, Daniela G. Vitali   +2 more
wiley   +1 more source

Beyond fructolysis: ketohexokinase orchestrates ER proteostasis in nutrient-stressed hepatocytes. [PDF]

Am J Physiol Gastrointest Liver Physiol
Elsaid S, Wu X, Hu J, Ambye N, Tee SS.
europepmc   +1 more source

Shade‐induced transcriptional reprogramming and metabolic adaptation in contrasting soybean genotypes

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Shade stress affects soybean yield in intercropping, but the molecular basis of cultivar‐specific tolerance is unclear. We analyzed shade‐tolerant (Guru) and sensitive (Heinong 53) soybeans under 30% and 70% shade using transcriptomic, physiological, and biochemical methods.
Fengyi Zhang, Runnan Zhou, Rongqiang Yuan, Xiao Zhu, Xinyue Zhang, Sobhi F. Lamlom, Dai Shi, Ahmed M. Abdelghany, Jidao Du, Honglei Ren, Lijuan Qiu   +10 more
wiley   +1 more source

Editorial: Cellular contributors and consequences of protein misfolding and aggregation. [PDF]

Front Mol Biosci
Arunagiri A, Sontag E, Kohler V, Venkatesan A.   +3 more
europepmc   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1622-1637, March 2026.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source

Bidirectional crosstalk between ER stress and lipid metabolism: From proteostasis to tumor adaptation. [PDF]

Cell Death Discov
Wu Y, Luo H, Pan Z, Chen W, Bi L.
europepmc   +1 more source

Tau Phosphorylation as an Adaptive Physiological Response: Implications for the Therapy of Tauopathies

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
Drawing on recent studies suggesting that tau phosphorylation is reversible, therapies for tauopathies could enhance reversibility, for example, by dismantling aggregated tau species. ABSTRACT Recent evidence demonstrates that tau phosphorylation, traditionally viewed as a hallmark of neurodegeneration, also occurs in completely reversible ...
Timothy Daly, Bruno P. Imbimbo
wiley   +1 more source