Results 281 to 290 of about 62,588 (334)

Assessing the Role of Chronic Stress in Aging Among Individuals Experiencing Homelessness: A Pilot Study

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims To investigate the relationship between chronic stress and telomere shortening among individuals experiencing homelessness compared to those in stable housing. Methods This pilot study analyzed a nested sample of 13 participants (8 males, 5 females) from a larger cohort of 90 individuals (65 unhoused, 25 housed ...
Raina K. Patel, Gesulla Cavanaugh, Patrick Hardigan, Raymond L. Ownby   +3 more
wiley   +1 more source

Editorial: Ubiquitin proteasome system (UPS) and ubiquitin-independent proteasome-mediated proteolysis (UIPP) crosstalk in development and disease. [PDF]

Front Cell Dev Biol
Sharon M, Stohwasser R.
europepmc   +1 more source

Prediabetes Associates With Musculoskeletal Alterations Independent of Total Body Adiposity

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Excess adiposity is a major risk factor for insulin resistance, prediabetes, and Type 2 diabetes and increases the risk for sarcopenia and osteosarcopenia later in life. It has been proposed that altered metabolic function and musculoskeletal status in people with obesity are directly linked, presumably because they share common ...
Alan Fappi, Clifton J. Holmes, Chao Cao, Vasavi Shabrish, Aman P. Aher, Karen Shen, Paul K. Commean, Dwight A. Towler, Dominic N. Reeds, Gretchen A. Meyer, Bettina Mittendorfer   +10 more
wiley   +1 more source

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis. [PDF]

Nat Cell Biol
Minetti A, Omrani O, Brenner C, Cansiz F, Imada S, Rösler J, Khawaled S, Allies G, Meckelmann SW, Gebert N, Heinze I, Rahnis N, Lu J, Spengler K, Rasa M, Cirri E, Heller R, Yilmaz Ö, Tasdogan A, Neri F, Ori A.   +20 more
europepmc   +1 more source

Largely Distinct Post‐Translational Modifications Differentiate Skeletal Muscle Wasting Caused by Cancer, Dexamethasone and Aging

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Skeletal muscle wasting and weakness are prominent disease features. Originally considered to arise from common transcriptional changes, recent analyses demonstrated that different stimuli induce muscle wasting via largely distinct mRNA and protein changes.
Anna Stephan, Flavia A. Graca, Suresh Poudel, Yingxue Fu, Yong‐Dong Wang, Myriam Labelle, Fabio Demontis   +6 more
wiley   +1 more source

Human clearance systems have a layered architecture across tissues and cell types that supports varied proteome compositions. [PDF]

Autophagy
Vinogradov-Talyah E, Edri B, Ravkaie L, Lazarescu O, Gharra F, Jubran J, Ben-Zvi A, Yeger-Lotem E.   +7 more
europepmc   +1 more source

The Proteomic Profiling of Circulating Extracellular Vesicles of Western Diet and Chemical‐Induced Murine MASH Model

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 2, February 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is an increasingly prevalent chronic liver condition that can progress to severe complications such as metabolic dysfunction‐associated steatohepatitis (MASH). Despite its growing burden, there are no reliable non‐invasive biomarkers for tracking disease progression.
Szu‐Jen Wang, Yung‐Ho Wang, Jee‐Fu Huang, En‐Sheng Lin, Wei‐Shiun Chen, Chia‐Yang Li, Chia‐Yen Dai, Wan‐Long Chuang, Ming‐Lung Yu, Shu‐Chi Wang   +9 more
wiley   +1 more source

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Revisiting molecular hydrogen signaling in mitochondria: Is the Rieske protein the entry point or a downstream sentinel? [PDF]

Redox Biol
Ostojic SM.
europepmc   +1 more source

<i>In vivo</i> manipulation of the protein homeostasis network in rhabdomyosarcoma. [PDF]

Oncotarget
Kwong K, Pan Y, Morales J, Watson M, Allegakoen DV, Lee AG, Bivona TG, Wipf P, Guerriero CJ, Brodsky JL, Sabnis AJ.   +10 more
europepmc   +1 more source