Results 21 to 30 of about 507 (153)

Photo‐Catalyzed Labeling of Amyloid Deposits in Human Tissue to Proteotype Amyloidosis Diseases

Aggregate
Over 40 amyloidogenic proteins have been identified to cause amyloidosis diseases in clinics. Tissue deposition of amyloid proteins entangled with interacting partners is a characteristic pathological hallmark of amyloidosis diseases.
Huan Feng, Fangliang Guo, Yan Wang, Meng You, Qiuxuan Xia, Wang Wan, Di Shen, Kaini Shen, Xin Zhang, Wei Li, Yu Liu   +10 more
doaj   +2 more sources

The astounding exhaustiveness and speed of the Astral mass analyzer for highly complex samples is a quantum leap in the functional analysis of microbiomes [PDF]

Microbiome
Background By analyzing the proteins which are the workhorses of biological systems, metaproteomics allows us to list the taxa present in any microbiota, monitor their relative biomass, and characterize the functioning of complex biological systems ...
Thibaut Dumas, Roxana Martinez Pinna, Clément Lozano, Sonja Radau, Olivier Pible, Lucia Grenga, Jean Armengaud   +6 more
doaj   +2 more sources

Proteotyping bacteria: Characterization, differentiation and identification of pneumococcus and other species within the Mitis Group of the genus Streptococcus by tandem mass spectrometry proteomics. [PDF]

PLoS ONE, 2018
A range of methodologies may be used for analyzing bacteria, depending on the purpose and the level of resolution needed. The capability for recognition of species distinctions within the complex spectrum of bacterial diversity is necessary for progress ...
Roger Karlsson, Lucia Gonzales-Siles, Margarita Gomila, Antonio Busquets, Francisco Salvà-Serra, Daniel Jaén-Luchoro, Hedvig E Jakobsson, Anders Karlsson, Fredrik Boulund, Erik Kristiansson, Edward R B Moore   +10 more
doaj   +4 more sources

Induced pluripotent stem cell-derived hepatocytes reveal TCA cycle disruption and the potential basis for triheptanoin treatment for malate dehydrogenase 2 deficiency [PDF]

Molecular Genetics and Metabolism Reports
Mitochondrial malate dehydrogenase 2 (MDH2) is crucial to cellular energy generation through direct participation in the tricarboxylic acid (TCA) cycle and the malate aspartate shuttle (MAS).
Déborah Mathis, Jasmine Koch, Sophie Koller, Kay Sauter, Christa Flück, Anne-Christine Uldry, Patrick Forny, D. Sean Froese, Alexander Laemmle   +8 more
doaj   +2 more sources

A Fulminant Case of Adenovirus Genotype C108 Infection in a Pediatric Stem Cell Transplant Recipient with x-Linked Lymphoproliferative Syndrome Type 1 [PDF]

Viruses
A 3-year-old male with X-linked lymphoproliferative syndrome type 1 underwent an unrelated umbilical cord blood transplant (UUCBT). The week prior to transplant the patient tested positive for adenovirus (HAdV) with a viral load of
Bradford A. Becken, Daryl M. Lamson, Gabriel Gonzalez, Sachit Patel, Kirsten St. George, Adriana E. Kajon   +5 more
doaj   +2 more sources

Comparison of two automated ApoE4 proteotype immunoassays

Alzheimer's & Dementia
Abstract Background The polymorphic APOE gene is a susceptibility gene for Alzheimer's disease (AD). The ε4 allele is associated with increased risk for AD, particularly late‐onset disease, in a dose‐dependent manner ...
Figdore, Daniel, Ashrafzadeh‐Kian, Susan, Bornhorst, Joshua A, Algeciras‐Schimnich, Alicia   +3 more
openaire   +3 more sources

Identification of Mycobacterium abscessus using the peaks of ribosomal protein L29, L30 and hemophore-related protein by MALDI-MS proteotyping [PDF]

Scientific Reports
Mycobacteroides (Mycobacterium) abscessus, which causes a variety of infectious diseases in humans, is becoming detected more frequently in clinical specimens as cases are spreading worldwide. Taxonomically, M.
Satomi Takei, Kanae Teramoto, Yuji Sekiguchi, Hiroaki Ihara, Mari Tohya, Shinichi Iwamoto, Koichi Tanaka, Abdullah Khasawneh, Yuki Horiuchi, Shigeki Misawa, Toshio Naito, Teruo Kirikae, Tatsuya Tada, Yoko Tabe   +13 more
doaj   +2 more sources

A hybrid DDA/DIA-PASEF based assay library for a deep proteotyping of triple-negative breast cancer [PDF]

Scientific Data
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and deeper proteome coverage is needed for its molecular characterization.
Petr Lapcik, Klara Synkova, Lucia Janacova, Pavla Bouchalova, David Potesil, Rudolf Nenutil, Pavel Bouchal   +6 more
doaj   +2 more sources

Olfactory proteotyping: towards the enlightenment of the neurodegeneration

Neural Regeneration Research, 2019
Joaquín Fernández-Irigoyen, Enrique Santamaría   +1 more
doaj   +3 more sources

An automated plasma-based proteotyping immunoassay for APOE ε4 zygosity classification in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Determining apolipoprotein E (APOE) ε4 allele status, a key genetic risk factor for Alzheimer's disease (AD), requires molecular genotyping infrastructure not widely accessible beyond specialized centers. METHODS A fully automated high‐throughput apoE E4 proteotyping immunoassay was evaluated for clinical performance (460 ...
Levin S, Engel B, Carlson C, Hinson J, Holland M, Figdore D, Lim HK, Tiers L, Bhatt K, Schlichtmann B, Hoffmann K, Bae YE, Szabo M, Lehmann S, Um YH, Algeciras-Schimnich A.   +15 more
europepmc   +2 more sources