Photo‐Catalyzed Labeling of Amyloid Deposits in Human Tissue to Proteotype Amyloidosis Diseases
AggregateOver 40 amyloidogenic proteins have been identified to cause amyloidosis diseases in clinics. Tissue deposition of amyloid proteins entangled with interacting partners is a characteristic pathological hallmark of amyloidosis diseases.
Huan Feng +10 more
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The astounding exhaustiveness and speed of the Astral mass analyzer for highly complex samples is a quantum leap in the functional analysis of microbiomes [PDF]
MicrobiomeBackground By analyzing the proteins which are the workhorses of biological systems, metaproteomics allows us to list the taxa present in any microbiota, monitor their relative biomass, and characterize the functioning of complex biological systems ...
Thibaut Dumas +6 more
doaj +2 more sources
Proteotyping as alternate typing method to differentiate Campylobacter coli clades [PDF]
Scientific Reports, 2019 Besides Campylobacter jejuni, Campylobacter coli is the most common bacterial cause of gastroenteritis worldwide. C. coli is subdivided into three clades, which are associated with sample source.
Bader, Oliver +8 more
core +4 more sources
Spatial single-cell proteotyping reveals immunotherapy-resistant features within the complex tumor microenvironment of metastatic NSCLC [PDF]
The Journal of Clinical InvestigationBACKGROUND Immune checkpoint inhibitors (ICIs) targeting the programmed cell death 1 axis have revolutionized metastatic non–small cell lung cancer (mNSCLC) treatment.
Kohsuke Isomoto +13 more
doaj +2 more sources
Induced pluripotent stem cell-derived hepatocytes reveal TCA cycle disruption and the potential basis for triheptanoin treatment for malate dehydrogenase 2 deficiency [PDF]
Molecular Genetics and Metabolism ReportsMitochondrial malate dehydrogenase 2 (MDH2) is crucial to cellular energy generation through direct participation in the tricarboxylic acid (TCA) cycle and the malate aspartate shuttle (MAS).
Déborah Mathis +8 more
doaj +2 more sources
Comparison of two automated ApoE4 proteotype immunoassays
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background The polymorphic APOE gene is a susceptibility gene for Alzheimer's disease (AD). The ε4 allele is associated with increased risk for AD, particularly late‐onset disease, in a dose‐dependent manner. Additionally, homozygous ε4/ε4 individuals have increased risk of adverse events when undergoing amyloid lowering treatments.
Daniel Figdore +3 more
wiley +3 more sources
A Fulminant Case of Adenovirus Genotype C108 Infection in a Pediatric Stem Cell Transplant Recipient with x-Linked Lymphoproliferative Syndrome Type 1 [PDF]
VirusesA 3-year-old male with X-linked lymphoproliferative syndrome type 1 underwent an unrelated umbilical cord blood transplant (UUCBT). The week prior to transplant the patient tested positive for adenovirus (HAdV) with a viral load of
Bradford A. Becken +5 more
doaj +2 more sources
Identification of Mycobacterium abscessus using the peaks of ribosomal protein L29, L30 and hemophore-related protein by MALDI-MS proteotyping [PDF]
Scientific ReportsMycobacteroides (Mycobacterium) abscessus, which causes a variety of infectious diseases in humans, is becoming detected more frequently in clinical specimens as cases are spreading worldwide. Taxonomically, M.
Satomi Takei +13 more
doaj +2 more sources
A hybrid DDA/DIA-PASEF based assay library for a deep proteotyping of triple-negative breast cancer [PDF]
Scientific DataTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and deeper proteome coverage is needed for its molecular characterization.
Petr Lapcik +6 more
doaj +2 more sources
Olfactory proteotyping: towards the enlightenment of the neurodegeneration
Neural Regeneration Research, 2019 Joaquín Fernández-Irigoyen +1 more
doaj +3 more sources