Results 31 to 40 of about 719 (174)

Proteotypic Differences of Follicular-Patterned Thyroid Neoplasms

Frontiers in Endocrinology, 2022
The diagnosis of follicular-patterned thyroid tumors such as follicular thyroid adenoma (FA), follicular thyroid carcinoma (FTC), and follicular variant of papillary thyroid carcinoma (FvPTC) remains challenging. This study aimed to explore the molecular differences among these three thyroid tumors by proteomic analysis.
Dongdong Huang, Huifang Zhang, Lu Li, Lu Li, Lu Li, Lu Li, Weigang Ge, Wei Liu, Wei Liu, Wei Liu, Zhen Dong, Zhen Dong, Zhen Dong, Jinlong Gao, Jinlong Gao, Jinlong Gao, Nan Yao, Wenxin Fu, Lingling Huang, Tiannan Guo, Tiannan Guo, Tiannan Guo, Yaoting Sun, Yaoting Sun, Yaoting Sun, Xiaodong Teng   +25 more
openaire   +3 more sources

MALDI-TOF mass spectrometry: an emerging technology for microbial identification and diagnosis [PDF]

, 2015
Currently microorganisms are best identified using 16S rRNA and 18S rRNA gene sequencing. However, in recent years Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometry (MALDI-TOF MS) has emerged as a potential tool for microbial ...
Jugsharan S. Virdi, Manish Kumar, Neelja Singhal, Pawan K. Kanaujia   +3 more
core   +9 more sources

Accuracy of an Automated Plasma Apolipoprotein E4 Proteotyping Immunoassay for Determination of APOE Genotype [PDF]

Alzheimers Dement
Abstract Background Anti‐amyloid therapies (AAT) for Alzheimer's disease are associated with the risk of amyloid‐related imaging abnormalities (ARIA). APOE4 homozygotes (E4/E4) have the highest risk, followed by APOE4 carriers (E4), making APOE genotyping essential for risk assessment.
Smith R, Alkhodair Y, Yadegari M, DeMarco M.   +3 more
europepmc   +2 more sources

Matrix-assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) Can Precisely Discriminate the Lineages of Listeria monocytogenes and Species of Listeria. [PDF]

PLoS ONE, 2016
The genetic lineages of Listeria monocytogenes and other species of the genus Listeria are correlated with pathogenesis in humans. Although matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has become a ...
Teruyo Ojima-Kato, Naomi Yamamoto, Hajime Takahashi, Hiroto Tamura   +3 more
doaj   +1 more source

Ex vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma [PDF]

, 2023
Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM remains incurable and in need of guidelines to identify effective personalized ...
Dietliker, Nadja, Festl, Yasmin, Goetze, Sandra, Hale, Benjamin D, Kachel, Paul, Kropivsek, Klara, Manz, Markus G, Mena, Julien, Severin, Yannik, Snijder, Berend, Tchinda, Joëlle, van Drogen, Audrey, Wegmann, Rebekka, Wollscheid, Bernd   +13 more
core   +1 more source

Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency [PDF]

, 2022
Multi-layered omics approaches can help define relationships between genetic factors, biochemical processes and phenotypes thus extending research of inherited diseases beyond identifying their monogenic cause 1.
Aebersold, Ruedi, Baumgartner, Matthias R, Bingisser, Anna, Bonilla, Ximena, Bürer, Céline, Cherkaoui, Sarah, Dermitzakis, Emmanouil T, Forny, Merima, Forny, Patrick, Frei, Caroline, Froese, D Sean, Goetze, Sandra, Harshman, Keith, Howald, Cédric, Lamparter, David, Morscher, Raphael J, Pedrioli, Patrick G A, Plessl, Tanja, Poms, Martin, Rätsch, Gunnar, Shao, Wenguang, Simmons, Luke, Traversi, Florian, van Drogen, Audrey, Wollscheid, Bernd, Xenarios, Ioannis, Zamboni, Nicola   +26 more
core   +2 more sources

Survival proteomes: the emerging proteotype of antimicrobial resistance [PDF]

FEMS Microbiology Reviews, 2016
Antimicrobial resistance is one of the greatest challenges in modern medicine. Infectious diseases that have historically been eliminated with routine antibiotic therapy are now re-emerging as life threatening illnesses. A better understanding of the specific mechanisms that contribute to resistance are required to optimize the treatment of infectious ...
Amber J, Park, Jonathan R, Krieger, Cezar M, Khursigara   +2 more
openaire   +2 more sources

Olfactory bulb proteomics reveals widespread proteostatic disturbances in mixed dementia and guides for potential serum biomarkers to discriminate alzheimer disease and mixed dementia phenotypes [PDF]

, 2021
The most common form of mixed dementia (MixD) is constituted by abnormal protein deposits associated with Alzheimer's disease (AD) that coexist with vascular disease.
Cartas-Cejudo, Paz, Fernández Irigoyen, Joaquín, Lachén Montes, Mercedes, Santamaría, Enrique, Íñigo-Marco, Ignacio   +4 more
core   +1 more source

Molecular evolution of human adenoviruses [PDF]

, 2013
The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the previously unsequenced HAdV ...
Betensky, Rebecca Aubrey, Chodosh, James, Dehghan, Shoaleh, Dyer, David W., Jones, Morris S., Lee, Jeong Yoon, Liu, Elizabeth B., Rajaiya, Jaya, Robinson, Christopher, Seto, Donald, Singh, Gurdeep, Yousuf, Mohammad Abu   +11 more
core   +1 more source

Proteotypic classification of spontaneous and transgenic mammary neoplasms [PDF]

Breast Cancer Research, 2004
Abstract Introduction Mammary tumors in mice are categorized by using morphologic and architectural criteria. Immunolabeling for terminal differentiation markers was compared among a variety of mouse mammary neoplasms because expression of terminal differentiation markers, and especially of keratins ...
Mikaelian, I, Blades, N, Churchill, G A, Fancher, K, Knowles, B B, Eppig, J T, Sundberg, J P   +6 more
openaire   +2 more sources