Results 51 to 60 of about 587 (160)

Proteotyping

, 2016
Proteotyping provides the means to identify and quantify the actual expression patterns of proteins and their associated pathways, which provides a more accurate picture of infectious agents and their pathogenic potential.
Karlsson, Anders, Boulund, Fredrik, Lindgren, \uc5sa, Kristiansson, Erik, Moore, Edward R.B., Svensson-Stadler, Liselott, Gonzales-Siles, Lucia, Karlsson, Roger, Edward R.B. Moore, Fredrik Boulund, Lucia Gonzales-Siles, Lindgren, Åsa,, Moore, Edward R.B.,, Roger Karlsson, Karlsson, Anders,, Anders Karlsson, Karlsson, Roger,, Erik Kristiansson, Åsa Lindgren, Gonzales-Siles, Lucia,, Liselott Svensson-Stadler, Boulund, Fredrik,, Svensson-Stadler, Liselott,, Kristiansson, Erik,   +23 more
core   +1 more source

Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma

npj Systems Biology and Applications, 2021
We proteotyped blood plasma from 30 mouse knockout strains and corresponding wild-type mice from the International Mouse Phenotyping Consortium. We used targeted proteomics with internal standards to quantify 375 proteins in 218 samples.
Yassene Mohammed, Sarah A. Michaud, Helena Pětrošová, Juncong Yang, Milan Ganguly, David Schibli, Ann M. Flenniken, Lauryl M. J. Nutter, Hibret A. Adissu, K. C. Kent Lloyd, Colin McKerlie, Christoph H. Borchers   +11 more
doaj   +1 more source

A prospectus for tailoring metaproteomics database using MS/MS proteotyping

, 2023
International audienceMetaproteomics can be applied even to minute amounts of samples for which metagenomics cannot be performed due to the limited amount of material or the presence of degraded DNA as for some historical artifacts.
Armengaud, Jean
core   +2 more sources

Strain-level proteotyping and expression of specific toxins in patients with recurrent

Journal of Infection
Objectives: Recurrent Clostridioides difficile infection (CDI) remains a major clinical challenge, and routine diagnostics that detect toxin genes rarely confirm toxin expression or resolve strain relatedness.
Guillem Seguí, Beatriz Piñeiro-Iglesias, Gunnar Jacobsson, Jon Edman Waller, Roger Karlsson   +4 more
doaj   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, Volume 600, Issue 15, Page 2117-2128, August 2026.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Meta‐Analysis: Redefining Liver Disease Risk in Heterozygous Alpha‐1 Antitrypsin Deficiency

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 4, Page 430-440, August 2026.
SERPINA1 MZ/SZ genotypes is a common but under‐recognised liver risk state. Despite modest shifts in liver function tests, it is associated with approximately doubled odds of fibrosis, cirrhosis, and liver transplantation, supporting its inclusion in chronic liver disease risk assessment.
Adam M. Syanda, Dimitra Georgantaki, Riona T. T. Linn, Amara Agbai, Hassan Tahir, Manako Sakai, Richard Thompson, Mariam Molokhia, S. Tamir Rashid   +8 more
wiley   +1 more source

Reconstruction of protein networks from an atlas of maize seed proteotypes [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Here we report deep, quantitative, and replicated proteome analysis of a developing multicellular organism. We quantified protein abundance and levels of protein phosphorylation during development of the maize seed. The depth and quantitative nature of the data enabled a network-based approach to identify kinase-substrate
Walley, Justin W, Shen, Zhouxin, Sartor, Ryan, Wu, Kevin J, Osborn, Joshua, Smith, Laurie G, Briggs, Steven P   +6 more
openaire   +5 more sources

Early Alzheimer´s disease blood biomarkers are associated with a higher risk for postoperative long‐term cognitive decline: Insights from the FINDERI study

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract BACKGROUND The study aim is to investigate whether blood biomarkers (BBMs) of Alzheimer's disease (AD) pathology are associated with postoperative cognitive dysfunction (POCD) after cardiac surgery. METHODS Cognitive performance was assessed before and 12 months postoperatively using the Montreal Cognitive Assessment (MoCA) and categorized ...
Niels Hansen, Monika Sadlonova, Hermann Esselmann, Christopher M. Celano, Carlotta Derad, Thomas Asendorf, Maike Hohberg, Mohammed Chebbok, Stephanie Heinemann, Barbara Morgado, Tobias Titsch, Katharina Packroß, Clara Maria Knopp, Matilda‐Marie Becker, Irina Günther, Iryna Krasiuk, Alina Isabel Rediske, Nicholas Paul Süttmann, Paul Thomas Itting, Oliver Wirths, Ingo Kutschka, Hassina Baraki, Christine A. F. von Arnim, Jens Wiltfang, FINDERI investigators   +24 more
wiley   +1 more source

Assigning statistical significance to proteotypic peptides via database searches [PDF]

Journal of Proteomics, 2011
Querying MS/MS spectra against a database containing only proteotypic peptides reduces data analysis time due to reduction of database size. Despite the speed advantage, this search strategy is challenged by issues of statistical significance and coverage.
Gelio, Alves, Aleksey Y, Ogurtsov, Yi-Kuo, Yu   +2 more
openaire   +2 more sources

Comparison of In‐Gel and SP3 Based Sample Preparation Protocols for LC‐MS/MS Based Proteomics

PROTEOMICS, Volume 26, Issue 7, Page 6-16, July 2026.
ABSTRACT Sensitivity, robustness, and reproducibility of sample preparation are main determinants of data quality in bottom‐up mass spectrometry‐based proteomics. To this end, in‐gel protein clean‐up and digestion has been used for decades and is characterized by its robustness and compatibility with harsh lysis conditions.
Luisa Schwarzmüller, Dario Frey, Piotr Zadora, Martin Schneider, Stefan Wiemann, Dominic Helm   +5 more
wiley   +1 more source