Results 51 to 60 of about 333 (136)
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract BACKGROUND The study aim is to investigate whether blood biomarkers (BBMs) of Alzheimer's disease (AD) pathology are associated with postoperative cognitive dysfunction (POCD) after cardiac surgery. METHODS Cognitive performance was assessed before and 12 months postoperatively using the Montreal Cognitive Assessment (MoCA) and categorized ...
Niels Hansen +24 more
wiley +1 more source
Comparison of In‐Gel and SP3 Based Sample Preparation Protocols for LC‐MS/MS Based Proteomics
PROTEOMICS, Volume 26, Issue 7, Page 6-16, July 2026.ABSTRACT Sensitivity, robustness, and reproducibility of sample preparation are main determinants of data quality in bottom‐up mass spectrometry‐based proteomics. To this end, in‐gel protein clean‐up and digestion has been used for decades and is characterized by its robustness and compatibility with harsh lysis conditions.
Luisa Schwarzmüller +5 more
wiley +1 more source
BMC Bioinformatics, 2012 Background Influenza is one of the oldest and deadliest infectious diseases known to man. Reassorted strains of the virus pose the greatest risk to both human and animal health and have been associated with all pandemics of the past century, with the ...
Lun Aaron TL +2 more
doaj +1 more source
Prevalence of high‐risk plasma p‐tau217 levels and 5‐year transition of risk status in 70‐year‐olds
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION High‐risk plasma p‐tau217 levels predict amyloid‐β pathology in Alzheimer's disease, but little is known about the prevalence and temporal dynamics in the general population. METHODS Participants from the Gothenburg H70 Birth Cohort Study in Sweden were examined (n = 1157) and re‐examined after 5–7 years (n = 771).
Anna Dittrich +9 more
wiley +1 more source
Development and validation of MethylCog, a blood DNA methylation proxy for cognition
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Heterogeneity in cognitive ability increases with age and predicts mild cognitive impairment (MCI) and dementia, but scalable blood‐based biomarkers are lacking. We developed and validated MethylCog, a parsimonious DNA methylation (DNAm) marker of general cognitive ability (g).
Deirdre M. O'Shea +9 more
wiley +1 more source
Reproducible quantitative proteotype data matrices for systems biology
Molecular Biology of the Cell, 2015 Historically, many mass spectrometry–based proteomic studies have aimed at compiling an inventory of protein compounds present in a biological sample, with the long-term objective of creating a proteome map of a species. However, to answer fundamental questions about the behavior of biological systems at the protein level, accurate and unbiased ...
Röst, Hannes L. +2 more
openaire +5 more sources
Sensitive and reproducible determination of clinical HDL proteotypes [PDF]
, 2020 Abstract Background High-density lipoprotein (HDL) is a heterogenous mixture of blood-circulating multimolecular particles containing many different proteins, lipids, and RNAs. Recent advancements in mass spectrometry-based proteotype analysis strategies enable the sensitive and reproducible ...
Sandra Goetze +9 more
openaire +1 more source
Usage and positivity rates of Alzheimer's disease biomarkers in a memory clinic
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Usage of biomarker tests for Alzheimer's disease pathology and rates of positivity were assessed at the Washington University Memory Diagnostic Center. METHODS Patients who underwent at least one biomarker test for clinical purposes between June 2021 and March 2025 were included (n = 1136). Data were retrospectively extracted from
Anna Hofmann +20 more
wiley +1 more source
Precision medicine for Alzheimer's disease in Down syndrome
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION Down syndrome (DS) exhibits a genetic form of Alzheimer's disease (AD). We used a blood‐based proteomic algorithm to predict cognitive status, treatment responders, and change to vitamin E in DS adults from a completed clinical trial, “Vitamin E in Aged Persons with Down Syndrome,” which originally showed no significant cognitive ...
Sonal Sukreet +6 more
wiley +1 more source
Penalized Estimation in Finite Mixtures of Multivariate Regression Models via the EM‐PGM Algorithm
Statistics in Medicine, Volume 45, Issue 8-9, April 2026.ABSTRACT In many areas of medical and life sciences research, multiple diagnostic criteria and phenotypic outcomes are assessed simultaneously to characterize diseases and biological traits. These multivariate outcomes are often associated with high‐dimensional covariates and subject to underlying population heterogeneity, presenting challenges for ...
Heeyeon Kang, Sunyoung Shin
wiley +1 more source