Results 51 to 60 of about 507 (153)

FluShuffle and FluResort: new algorithms to identify reassorted strains of the influenza virus by mass spectrometry

BMC Bioinformatics, 2012
Background Influenza is one of the oldest and deadliest infectious diseases known to man. Reassorted strains of the virus pose the greatest risk to both human and animal health and have been associated with all pandemics of the past century, with the ...
Lun Aaron TL, Wong Jason WH, Downard Kevin M   +2 more
doaj   +1 more source

Assigning statistical significance to proteotypic peptides via database searches [PDF]

Journal of Proteomics, 2011
Querying MS/MS spectra against a database containing only proteotypic peptides reduces data analysis time due to reduction of database size. Despite the speed advantage, this search strategy is challenged by issues of statistical significance and coverage.
Gelio, Alves, Aleksey Y, Ogurtsov, Yi-Kuo, Yu   +2 more
openaire   +2 more sources

Proteotyping as alternate typing method to differentiate Campylobacter coli clades

, 2019
Besides Campylobacter jejuni, Campylobacter coli is the most common bacterial cause of gastroenteritis worldwide. C. coli is subdivided into three clades, which are associated with sample source.
Bader, Oliver, Emele, Matthias Frederik, Lugert, Raimond, Možina, Sonja Smole, Masanta, Wycliffe Omurwa, Riedel, Thomas, Bohne, Wolfgang, Groß, Uwe, Zautner, Andreas Erich   +8 more
core   +1 more source

Development and validation of MethylCog, a blood DNA methylation proxy for cognition

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Heterogeneity in cognitive ability increases with age and predicts mild cognitive impairment (MCI) and dementia, but scalable blood‐based biomarkers are lacking. We developed and validated MethylCog, a parsimonious DNA methylation (DNAm) marker of general cognitive ability (g).
Deirdre M. O'Shea, Lily Wang, David Lukacsovich, Devi Dhanekula, Wei Zhang, Conor Galvin, Mahesh Joshi, Lilah Besser, Tatjana Rundek, James E. Galvin   +9 more
wiley   +1 more source

Proteotyping: Tandem Mass Spectrometry Shotgun Proteomic Characterization and Typing of Pathogenic Microorganisms

, 2016
Proteotyping provides the means to identify and quantify the actual expression patterns of proteins and their associated pathways, which provides a more accurate picture of infectious agents and their pathogenic potential.
Karlsson, Anders, Boulund, Fredrik, Lindgren, \uc5sa, Kristiansson, Erik, Moore, Edward R.B., Svensson-Stadler, Liselott, Gonzales-Siles, Lucia, Karlsson, Roger   +7 more
core   +1 more source

Usage and positivity rates of Alzheimer's disease biomarkers in a memory clinic

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Usage of biomarker tests for Alzheimer's disease pathology and rates of positivity were assessed at the Washington University Memory Diagnostic Center. METHODS Patients who underwent at least one biomarker test for clinical purposes between June 2021 and March 2025 were included (n = 1136). Data were retrospectively extracted from
Anna Hofmann, Benjamin Saef, William J. B. Powell, Madeline Paczynski, Maria R. Ponisio, Clara Vila‐Castelar, Zachary Posey, Inez Y. Oh, Mackenzie R. Hofford, Melissa Aldinger, Randall J. Bateman, Cyrus A. Raji, Tammie L. S. Benzinger, Carlos Cruchaga, Alan Dow, Rachel Buckley, Chengjie Xiong, John C. Morris, B. Joy Snider, Aditi Gupta, Suzanne E. Schindler   +20 more
wiley   +1 more source

Precision medicine for Alzheimer's disease in Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Down syndrome (DS) exhibits a genetic form of Alzheimer's disease (AD). We used a blood‐based proteomic algorithm to predict cognitive status, treatment responders, and change to vitamin E in DS adults from a completed clinical trial, “Vitamin E in Aged Persons with Down Syndrome,” which originally showed no significant cognitive ...
Sonal Sukreet, Elise K. Kim, Melissa Petersen, Fan Zhang, Sid E. O'Bryant, Michael S. Rafii, Robert A. Rissman   +6 more
wiley   +1 more source

Reproducible quantitative proteotype data matrices for systems biology

Molecular Biology of the Cell, 2015
Historically, many mass spectrometry–based proteomic studies have aimed at compiling an inventory of protein compounds present in a biological sample, with the long-term objective of creating a proteome map of a species. However, to answer fundamental questions about the behavior of biological systems at the protein level, accurate and unbiased ...
Röst, Hannes L., Malmström, Lars, Aebersold, Ruedi   +2 more
openaire   +5 more sources

Penalized Estimation in Finite Mixtures of Multivariate Regression Models via the EM‐PGM Algorithm

Statistics in Medicine, Volume 45, Issue 8-9, April 2026.
ABSTRACT In many areas of medical and life sciences research, multiple diagnostic criteria and phenotypic outcomes are assessed simultaneously to characterize diseases and biological traits. These multivariate outcomes are often associated with high‐dimensional covariates and subject to underlying population heterogeneity, presenting challenges for ...
Heeyeon Kang, Sunyoung Shin
wiley   +1 more source

High Quality Catalog of Proteotypic Peptides from Human Heart [PDF]

Journal of Proteome Research, 2008
Proteomics research is beginning to expand beyond the more traditional shotgun analysis of protein mixtures to include targeted analyses of specific proteins using mass spectrometry. Integral to the development of a robust assay based on targeted mass spectrometry is prior knowledge of which peptides provide an accurate and sensitive proxy of the ...
Kelli G, Kline, Barbara, Frewen, Michael R, Bristow, Michael J, Maccoss, Christine C, Wu   +4 more
openaire   +2 more sources