Results 61 to 70 of about 333 (136)

High Quality Catalog of Proteotypic Peptides from Human Heart [PDF]

Journal of Proteome Research, 2008
Proteomics research is beginning to expand beyond the more traditional shotgun analysis of protein mixtures to include targeted analyses of specific proteins using mass spectrometry. Integral to the development of a robust assay based on targeted mass spectrometry is prior knowledge of which peptides provide an accurate and sensitive proxy of the ...
Kelli G, Kline, Barbara, Frewen, Michael R, Bristow, Michael J, Maccoss, Christine C, Wu   +4 more
openaire   +2 more sources

Proteotype coevolution and quantitative diversity across 11 mammalian species

Science Advances, 2022
Evolutionary profiling has been largely limited to the nucleotide level. Using consistent proteomic methods, we quantified proteomic and phosphoproteomic layers in fibroblasts from 11 common mammalian species, with transcriptomes as reference. Covariation analysis indicates that transcript and protein expression levels and variabilities across mammals ...
Qian Ba, Yuanyuan Hei, Anasuya Dighe, Wenxue Li, Jamie Maziarz, Irene Pak, Shisheng Wang, Günter P. Wagner, Yansheng Liu   +8 more
openaire   +2 more sources

Early Cancer Detection: What's Going on and What's Next

MedComm, Volume 7, Issue 3, March 2026.
Multicancer early detection (MCED) platforms have emerged as a promising strategy for the safe and effective early detection of multiple cancer types, with the potential to reduce metastatic burden and improve clinical outcomes, particularly for aggressive malignancies that lack effective population‐level screening.
Emma Di Carlo
wiley   +1 more source

A Novel Autoimmune Presentation of Wiskott‐Aldrich Syndrome: Type 1 Diabetes

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized by microthrombocytopenia, eczema, and recurrent infections. While autoimmune complications are common in WAS, including autoimmune hemolytic anemia, vasculitis, and glomerulonephritis, type 1 diabetes has not been previously described.
Melanie Natasha Rayan, Yara Alshawabkeh, Samad Zia, Luma Ghalib   +3 more
wiley   +1 more source

The olfactory bulb proteotype differs across frontotemporal dementia spectrum

Journal of Proteomics, 2019
Mild olfactory dysfunction has been observed in frontotemporal dementias (FTD). However, the underlying molecular mechanisms associated to this deficit are poorly understood. We applied quantitative proteomics to analyze pathological effects on the olfactory bulb (OB) from progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTLD-
Lachén-Montes, Mercedes, González-Morales, Andrea, Schvartz, Domitille, Zelaya, María Victoria, Ausin, Karina, Fernández-Irigoyen, Joaquín, Sanchez, Jean-Charles, Santamaría, Enrique   +7 more
openaire   +7 more sources

The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 201-213, February 2026.
ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz, Camila S. Stolf, Kai Bao, Mabelle F. Monteiro, Lucas M. Carvalho, Angelika Silbereisen, Georgios N. Belibasakis, Renato C. V. Casarin, Nagihan Bostanci   +8 more
wiley   +1 more source

Apolipoprotein E ε4 homozygosity exacerbates retinal and cerebral microvascular dysfunction in Alzheimer's disease: A mediation analysis of vascular contributions to cognitive decline

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer's disease (AD), with homozygous carriers (ε4/ε4) experiencing accelerated cognitive decline. While its role in amyloid and tau pathology is established, its impact on retinal and cerebral microvasculature remains underexplored. METHODS A total of 107 AD (
Yuntao Liu, Hanyu Zhu, Youjie Wang, Xiaoqian Luan, Jiahui Chen, Jiajing Qian, Jianing Shen, Yinhe Liu, Caiyun Wen, Lin Cao, Bo Tang, Ho Ko, William Robert Kwapong, Zhen Wang   +13 more
wiley   +1 more source

Plasma ApoE proteotyping for ApoE ε4 stratification in the anti-amyloid therapies era

Alzheimer’s Research & Therapy
Background Apolipoprotein E (ApoE) ε4 status informs risk stratification and safety management for anti-amyloid therapies, but genotyping typically requires dedicated procedures, longer turnaround times, and higher costs compared with automated ...
Federico Coraglia, Giordano Cecchetti, Giulia Rugarli, Edoardo G. Spinelli, Alma Ghirelli, Stefano Pisano, Elisa Canu, Massimo Filippi, Federica Agosta   +8 more
doaj   +1 more source

Investigating Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease: ExosomeAD Study Design and Baseline Characteristics

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Brain‐derived salivary extracellular vesicles (EVs) contain mRNA, miRNA, and protein species which have the potential to be used for molecular characterization of brain health. Prior analysis of salivary EV mRNA identified Alzheimer's disease (AD)‐ and inflammation‐related biomarkers that may be diagnostically useful in this regard,
Victoria Sanborn, Jonathan D. Drake, Hannah Alaimo, Em Teixeira, Jenna R Pracht, Charles Denby, Mandy G Pereira, Sicheng Wen, Peter J. Quesenberry, Jill A. Kreiling, Lori A. Daiello   +10 more
wiley   +1 more source

Plasma Biomarker Characterization of Alzheimer’s Disease Psychosis in Study ACP‐204‐006

Alzheimer's &Dementia, Volume 21, Issue S5, December 2025.
Abstract Background Alzheimer’s disease (AD) is diagnosed and staged based on biological criteria that utilize biomarkers. However, biomarker data are sparse in patients with psychosis and significant cognitive decline. Here we present screening metrics based on study biomarker requirements in patients diagnosed using 2011 National Institute on Aging ...
Bryan Dirks, Samantha M Friend, Becky M Howell, Christine M Murphy, Peter M Zhang, Xiaoshu Feng, Sanjeev S Pathak   +6 more
wiley   +1 more source