Results 61 to 70 of about 507 (153)
Proteotype coevolution and quantitative diversity across 11 mammalian species
Science Advances, 2022 Evolutionary profiling has been largely limited to the nucleotide level. Using consistent proteomic methods, we quantified proteomic and phosphoproteomic layers in fibroblasts from 11 common mammalian species, with transcriptomes as reference. Covariation analysis indicates that transcript and protein expression levels and variabilities across mammals ...
Qian Ba +8 more
openaire +2 more sources
Early Cancer Detection: What's Going on and What's Next
MedComm, Volume 7, Issue 3, March 2026.Multicancer early detection (MCED) platforms have emerged as a promising strategy for the safe and effective early detection of multiple cancer types, with the potential to reduce metastatic burden and improve clinical outcomes, particularly for aggressive malignancies that lack effective population‐level screening.
Emma Di Carlo
wiley +1 more source
A Novel Autoimmune Presentation of Wiskott‐Aldrich Syndrome: Type 1 Diabetes
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.ABSTRACT Background Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized by microthrombocytopenia, eczema, and recurrent infections. While autoimmune complications are common in WAS, including autoimmune hemolytic anemia, vasculitis, and glomerulonephritis, type 1 diabetes has not been previously described.
Melanie Natasha Rayan +3 more
wiley +1 more source
, 2019 Tandem mass spectrometry-based proteotyping allows characterizing microorganisms in terms of taxonomy and is becoming an important tool for investigating microbial diversity from several ecosystems.
Jean Armengaud (16857) +5 more
core +1 more source
The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring
Journal of Clinical Periodontology, Volume 53, Issue 2, Page 201-213, February 2026.ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz +8 more
wiley +1 more source
Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer's disease (AD), with homozygous carriers (ε4/ε4) experiencing accelerated cognitive decline. While its role in amyloid and tau pathology is established, its impact on retinal and cerebral microvasculature remains underexplored. METHODS A total of 107 AD (
Yuntao Liu +13 more
wiley +1 more source
The olfactory bulb proteotype differs across frontotemporal dementia spectrum
Journal of Proteomics, 2019 Mild olfactory dysfunction has been observed in frontotemporal dementias (FTD). However, the underlying molecular mechanisms associated to this deficit are poorly understood. We applied quantitative proteomics to analyze pathological effects on the olfactory bulb (OB) from progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTLD-
Lachén-Montes, Mercedes +7 more
openaire +7 more sources
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Brain‐derived salivary extracellular vesicles (EVs) contain mRNA, miRNA, and protein species which have the potential to be used for molecular characterization of brain health. Prior analysis of salivary EV mRNA identified Alzheimer's disease (AD)‐ and inflammation‐related biomarkers that may be diagnostically useful in this regard,
Victoria Sanborn +10 more
wiley +1 more source
A prospectus for tailoring metaproteomics database using MS/MS proteotyping
, 2023 International audienceMetaproteomics can be applied even to minute amounts of samples for which metagenomics cannot be performed due to the limited amount of material or the presence of degraded DNA as for some historical artifacts.
Armengaud, Jean
core
, 2019 Tandem mass spectrometry-based proteotyping allows characterizing microorganisms in terms of taxonomy and is becoming an important tool for investigating microbial diversity from several ecosystems.
Jean Armengaud (16857) +5 more
core +1 more source