Investigation of MALDI-TOF Mass Spectrometry for Assessing the Molecular Diversity of Campylobacter jejuni and Comparison with MLST and cgMLST: A Luxembourg One-Health Study [PDF]
, 2021 There is a need for active molecular surveillance of human and veterinary Campylobacter infections. However, sequencing of all isolates is associated with high costs and a considerable workload. Thus, there is a need for a straightforward complementary
Becker, Sören L. +7 more
core +3 more sources
Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals [PDF]
Cell, 2019 ISSN:0092 ...
Romanov, Natalie +5 more
openaire +5 more sources
, 2023 PM003/2016. Publisher Copyright: © 2022 The Author(s)The capabilities of bioanalytical mass spectrometry to (i) detect and differentiate viruses at the peptide level whilst maintaining high sample throughput and (ii) to provide diagnosis and prognosis ...
Almeida-Santos, Maria M. +10 more
core +3 more sources
Reproducible quantitative proteotype data matrices for systems biology
Molecular Biology of the Cell, 2015 Historically, many mass spectrometry–based proteomic studies have aimed at compiling an inventory of protein compounds present in a biological sample, with the long-term objective of creating a proteome map of a species. However, to answer fundamental questions about the behavior of biological systems at the protein level, accurate and unbiased ...
Röst, Hannes L. +2 more
openaire +3 more sources
Discrimination between hypervirulent and non-hypervirulent ribotypes of Clostridioides difficile by MALDI-TOF mass spectrometry and machine learning [PDF]
, 2023 Hypervirulent ribotypes (HVRTs) of Clostridioides difcile such as ribotype (RT) 027 are epidemiologically important. This study evaluated whether MALDI-TOF can distinguish between strains of HVRTs and non-HVRTs commonly found in Europe.
Abdrabou, Ahmed Mohamed Mostafa +8 more
core +1 more source
The olfactory bulb proteotype differs across frontotemporal dementia spectrum
Journal of Proteomics, 2019 Mild olfactory dysfunction has been observed in frontotemporal dementias (FTD). However, the underlying molecular mechanisms associated to this deficit are poorly understood. We applied quantitative proteomics to analyze pathological effects on the olfactory bulb (OB) from progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTLD-
Lachén-Montes, Mercedes +7 more
openaire +6 more sources
Evaluation of Filter, Paramagnetic, and STAGETips Aided Workflows for Proteome Profiling of Symbiodiniaceae Dinoflagellate [PDF]
, 2021 The integrity of coral reef ecosystems worldwide rests on a fine-tuned symbiotic interaction between an invertebrate and a dinoflagellate microalga from the family Symbiodiniaceae.
Kumar, M +6 more
core +3 more sources
Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia. [PDF]
Nat CommunDeep single-cell multi-omic profiling offers a promising approach to understand and overcome drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML). Here, we combine single-cell ex vivo drug profiling (pharmacoscopy) with single-cell
Wegmann R +41 more
europepmc +2 more sources
A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: Findings from a multi cohort validity analysis [PDF]
, 2021 BACKGROUND: The development of blood-based biomarker tests that are accurate and robust for Alzheimer\u27s disease (AD) pathology have the potential to aid clinical diagnosis and facilitate enrollment in AD drug trials.
Bateman, Randall J +14 more
core +1 more source
Development of a rapid and specific MALDI-TOF mass spectrometric assay for SARS-CoV-2 detection [PDF]
, 2023 We have developed a rapid and highly specific assay for detecting and monitoring SARS-CoV-2 infections by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
Barka, Frederik +6 more
core +1 more source