Results 61 to 70 of about 587 (160)

Prevalence of high‐risk plasma p‐tau217 levels and 5‐year transition of risk status in 70‐year‐olds

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION High‐risk plasma p‐tau217 levels predict amyloid‐β pathology in Alzheimer's disease, but little is known about the prevalence and temporal dynamics in the general population. METHODS Participants from the Gothenburg H70 Birth Cohort Study in Sweden were examined (n = 1157) and re‐examined after 5–7 years (n = 771).
Anna Dittrich, Burak Arslan, Tobias Skillbäck, Lina Rydén, Hlin Kvartsberg, Johan Gobom, Kaj Blennow, Henrik Zetterberg, Silke Kern, Ingmar Skoog   +9 more
wiley   +1 more source

Proteotyping of Streptococcus pneumoniae, using tandem mass spectrometry for identification of biomarkers for species and strain differentiation

, 2016
Background. Streptococcus pneumoniae (pneumococcus) is the leading cause of community-acquired pneumonia and a major cause of morbidity and mortality worldwide. S.
Jakobsson, Hedvig E, Gonzales-Siles, Lucia, Boulund, Fredrik,, Salvà-Serra, Francisco, Karlsson, Roger, Moore, Edward R.B.,, Kristiansson, Erik,   +6 more
core   +2 more sources

FluShuffle and FluResort: new algorithms to identify reassorted strains of the influenza virus by mass spectrometry

BMC Bioinformatics, 2012
Background Influenza is one of the oldest and deadliest infectious diseases known to man. Reassorted strains of the virus pose the greatest risk to both human and animal health and have been associated with all pandemics of the past century, with the ...
Lun Aaron TL, Wong Jason WH, Downard Kevin M   +2 more
doaj   +1 more source

Reproducible quantitative proteotype data matrices for systems biology

Molecular Biology of the Cell, 2015
Historically, many mass spectrometry–based proteomic studies have aimed at compiling an inventory of protein compounds present in a biological sample, with the long-term objective of creating a proteome map of a species. However, to answer fundamental questions about the behavior of biological systems at the protein level, accurate and unbiased ...
Röst, Hannes L., Malmström, Lars, Aebersold, Ruedi   +2 more
openaire   +5 more sources

Development and validation of MethylCog, a blood DNA methylation proxy for cognition

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Heterogeneity in cognitive ability increases with age and predicts mild cognitive impairment (MCI) and dementia, but scalable blood‐based biomarkers are lacking. We developed and validated MethylCog, a parsimonious DNA methylation (DNAm) marker of general cognitive ability (g).
Deirdre M. O'Shea, Lily Wang, David Lukacsovich, Devi Dhanekula, Wei Zhang, Conor Galvin, Mahesh Joshi, Lilah Besser, Tatjana Rundek, James E. Galvin   +9 more
wiley   +1 more source

Sensitive and reproducible determination of clinical HDL proteotypes [PDF]

, 2020
Abstract Background High-density lipoprotein (HDL) is a heterogenous mixture of blood-circulating multimolecular particles containing many different proteins, lipids, and RNAs. Recent advancements in mass spectrometry-based proteotype analysis strategies enable the sensitive and reproducible ...
Sandra Goetze, Kathrin Frey, Lucia Rohrer, Silvija Radosavljevic, Jan Krützfeldt, Ulf Landmesser, Marco Bueter, Patrick G. A. Pedrioli, Arnold von Eckardstein, Bernd Wollscheid   +9 more
openaire   +1 more source

Usage and positivity rates of Alzheimer's disease biomarkers in a memory clinic

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Usage of biomarker tests for Alzheimer's disease pathology and rates of positivity were assessed at the Washington University Memory Diagnostic Center. METHODS Patients who underwent at least one biomarker test for clinical purposes between June 2021 and March 2025 were included (n = 1136). Data were retrospectively extracted from
Anna Hofmann, Benjamin Saef, William J. B. Powell, Madeline Paczynski, Maria R. Ponisio, Clara Vila‐Castelar, Zachary Posey, Inez Y. Oh, Mackenzie R. Hofford, Melissa Aldinger, Randall J. Bateman, Cyrus A. Raji, Tammie L. S. Benzinger, Carlos Cruchaga, Alan Dow, Rachel Buckley, Chengjie Xiong, John C. Morris, B. Joy Snider, Aditi Gupta, Suzanne E. Schindler   +20 more
wiley   +1 more source

The olfactory bulb proteotype differs across frontotemporal dementia spectrum

Journal of Proteomics, 2019
Mild olfactory dysfunction has been observed in frontotemporal dementias (FTD). However, the underlying molecular mechanisms associated to this deficit are poorly understood. We applied quantitative proteomics to analyze pathological effects on the olfactory bulb (OB) from progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTLD-
Lachén-Montes, Mercedes, González-Morales, Andrea, Schvartz, Domitille, Zelaya, María Victoria, Ausin, Karina, Fernández-Irigoyen, Joaquín, Sanchez, Jean-Charles, Santamaría, Enrique   +7 more
openaire   +6 more sources

Precision medicine for Alzheimer's disease in Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Down syndrome (DS) exhibits a genetic form of Alzheimer's disease (AD). We used a blood‐based proteomic algorithm to predict cognitive status, treatment responders, and change to vitamin E in DS adults from a completed clinical trial, “Vitamin E in Aged Persons with Down Syndrome,” which originally showed no significant cognitive ...
Sonal Sukreet, Elise K. Kim, Melissa Petersen, Fan Zhang, Sid E. O'Bryant, Michael S. Rafii, Robert A. Rissman   +6 more
wiley   +1 more source

Penalized Estimation in Finite Mixtures of Multivariate Regression Models via the EM‐PGM Algorithm

Statistics in Medicine, Volume 45, Issue 8-9, April 2026.
ABSTRACT In many areas of medical and life sciences research, multiple diagnostic criteria and phenotypic outcomes are assessed simultaneously to characterize diseases and biological traits. These multivariate outcomes are often associated with high‐dimensional covariates and subject to underlying population heterogeneity, presenting challenges for ...
Heeyeon Kang, Sunyoung Shin
wiley   +1 more source