Results 81 to 90 of about 719 (174)

A Novel Autoimmune Presentation of Wiskott‐Aldrich Syndrome: Type 1 Diabetes

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized by microthrombocytopenia, eczema, and recurrent infections. While autoimmune complications are common in WAS, including autoimmune hemolytic anemia, vasculitis, and glomerulonephritis, type 1 diabetes has not been previously described.
Melanie Natasha Rayan, Yara Alshawabkeh, Samad Zia, Luma Ghalib   +3 more
wiley   +1 more source

The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 201-213, February 2026.
ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz, Camila S. Stolf, Kai Bao, Mabelle F. Monteiro, Lucas M. Carvalho, Angelika Silbereisen, Georgios N. Belibasakis, Renato C. V. Casarin, Nagihan Bostanci   +8 more
wiley   +1 more source

Assessment of a plasma amyloid probability score to estimate amyloid positron emission tomography findings among adults with cognitive impairment [PDF]

, 2022
Importance: The diagnostic evaluation for Alzheimer disease may be improved by a blood-based diagnostic test identifying presence of brain amyloid plaque pathology.
et al,, Holtzman, David M, Hu, Yan, Siegel, Barry A   +3 more
core   +1 more source

Apolipoprotein E ε4 homozygosity exacerbates retinal and cerebral microvascular dysfunction in Alzheimer's disease: A mediation analysis of vascular contributions to cognitive decline

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer's disease (AD), with homozygous carriers (ε4/ε4) experiencing accelerated cognitive decline. While its role in amyloid and tau pathology is established, its impact on retinal and cerebral microvasculature remains underexplored. METHODS A total of 107 AD (
Yuntao Liu, Hanyu Zhu, Youjie Wang, Xiaoqian Luan, Jiahui Chen, Jiajing Qian, Jianing Shen, Yinhe Liu, Caiyun Wen, Lin Cao, Bo Tang, Ho Ko, William Robert Kwapong, Zhen Wang   +13 more
wiley   +1 more source

Comparison of two automated ApoE4 proteotype immunoassays

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background The polymorphic APOE gene is a susceptibility gene for Alzheimer's disease (AD). The ε4 allele is associated with increased risk for AD, particularly late‐onset disease, in a dose‐dependent manner. Additionally, homozygous ε4/ε4 individuals have increased risk of adverse events when undergoing amyloid lowering treatments.
Daniel Figdore, Susan Ashrafzadeh‐Kian, Joshua A Bornhorst, Alicia Algeciras‐Schimnich   +3 more
wiley   +1 more source

Investigating Salivary Extracellular Vesicles as Biomarkers for Alzheimer's Disease: ExosomeAD Study Design and Baseline Characteristics

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Brain‐derived salivary extracellular vesicles (EVs) contain mRNA, miRNA, and protein species which have the potential to be used for molecular characterization of brain health. Prior analysis of salivary EV mRNA identified Alzheimer's disease (AD)‐ and inflammation‐related biomarkers that may be diagnostically useful in this regard,
Victoria Sanborn, Jonathan D. Drake, Hannah Alaimo, Em Teixeira, Jenna R Pracht, Charles Denby, Mandy G Pereira, Sicheng Wen, Peter J. Quesenberry, Jill A. Kreiling, Lori A. Daiello   +10 more
wiley   +1 more source

High-resolution differentiation and identification of the clinically relevant pathogens Haemophilus influenzae and Haemophilus aegyptius: combined whole-cell MALDI-TOF MS and nano-LC-MS/MS proteotyping for defining protein biomarkers

Microbiology Spectrum
Precise differentiation between closely related species is crucial for effective clinical diagnosis and treatment. Haemophilus influenzae and Haemophilus aegyptius are phenotypically similar but differ in pathogenic potential, with H. influenzae involved
Hamideh Hamidi, Guillem Seguí, Alexandra Gillberg, Alireza Ghassempour, Edward R. B. Moore, Roger Karlsson   +5 more
doaj   +1 more source

Smelling the Dark Proteome : Functional Characterization of PITH Domain-Containing Protein 1 (C1orf128) in Olfactory Metabolism [PDF]

, 2021
The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining in public resources and omics ...
Ausín, Karina, Azkargorta, Mikel, de la Torre, Rafael, Elortza, Felix, Fernández-Irigoyen, Joaquín, Ferrer, Isidre, Iloro, Ibon, Kondo, Hiroyuki, Lachén-Montes, Mercedes, Mendizuri, Naroa, Ohigashi, Izumi, Pérez-Mediavilla, Alberto, Robledo, Patricia, Santamaría, Enrique   +13 more
core  

MALDI TOF MS and currently related proteomic technologies in reconciling bacterial systematics [PDF]

, 2020
The chapter is on development and application of matrix assisted laser desorption ionisation time of flight mass spectrometry (MALDI-TOF) to identification and and classification of ...
Belgacem, Omar, Bruce, Kenneth, Cave, Rory, Dekio, Itaru, Duncan, Louise, Gharbia, Saheer E., Mkrtchyan, Hermine V., Selami, Lyna, Shah, Ajit J., Shah, Haroun N., Shah, Laila, Ward, Malcom, Xu, Zhen   +12 more
core   +1 more source

Plasma Biomarker Characterization of Alzheimer’s Disease Psychosis in Study ACP‐204‐006

Alzheimer's &Dementia, Volume 21, Issue S5, December 2025.
Abstract Background Alzheimer’s disease (AD) is diagnosed and staged based on biological criteria that utilize biomarkers. However, biomarker data are sparse in patients with psychosis and significant cognitive decline. Here we present screening metrics based on study biomarker requirements in patients diagnosed using 2011 National Institute on Aging ...
Bryan Dirks, Samantha M Friend, Becky M Howell, Christine M Murphy, Peter M Zhang, Xiaoshu Feng, Sanjeev S Pathak   +6 more
wiley   +1 more source