Results 71 to 80 of about 507 (153)

Plasma Biomarker Characterization of Alzheimer’s Disease Psychosis in Study ACP‐204‐006

Alzheimer's &Dementia, Volume 21, Issue S5, December 2025.
Abstract Background Alzheimer’s disease (AD) is diagnosed and staged based on biological criteria that utilize biomarkers. However, biomarker data are sparse in patients with psychosis and significant cognitive decline. Here we present screening metrics based on study biomarker requirements in patients diagnosed using 2011 National Institute on Aging ...
Bryan Dirks, Samantha M Friend, Becky M Howell, Christine M Murphy, Peter M Zhang, Xiaoshu Feng, Sanjeev S Pathak   +6 more
wiley   +1 more source

Retinal microvascular alterations in Alzheimer's disease: Linking blood plasma biomarkers and cerebral small vessel pathology

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract BACKGROUND Retinal microvascular alterations, detectable via color fundus photography (CFP), may reflect cerebral microvascular pathology in Alzheimer's disease (AD). However, their associations with blood‐based biomarkers and cerebral small vessel disease (SVD) remain unclear.
William Robert Kwapong, Ning Wu, Weihong Lin, Jianing Shen, Youjie Wang, Jiajing Qian, Caiyun Wen, Xiaoqian Luan, Yuntao Liu, Haoran Cheng, Huihua Qiu, Carol Y. Cheung, Chunwen Zheng, Yinhe Liu, Yunjun Yang, Vincent Mok, Zhen Wang   +16 more
wiley   +1 more source

The Brain Health Index: Integrating vulnerability, resilience, and cognitive function into a unified measure of cognitive health and risk of neurodegenerative disease

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION Assessing brain health and identifying cognitive impairment risk remains challenging, with only 11.4% of MCI cases receiving timely diagnoses. We developed the Brain Health Index (BHI), integrating the Vulnerability Index, Resilience Index, and Number Symbol Coding Task into a unified metric. METHODS We evaluated 469 participants (
Michael J. Kleiman, Gregory Gibbs, Mahesh S. Joshi, James E. Galvin   +3 more
wiley   +1 more source

Association and interaction of blood homocysteine and p‐tau217 levels with temporal cortical thinning and cognitive impairment in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract INTRODUCTION The relationships between blood homocysteine (Hcy), amyloid beta (Aβ), tau pathology, and their combined effects on cortical thinning and cognitive impairment in Alzheimer's disease (AD) remain poorly understood. METHODS Participants were stratified into Aβ+ and Aβ− groups by positron emission tomography.
Qiang Wang, Xiaomei Zhong, Pengbo Gao, Zhidai Xiao, Ben Chen, Haoye Tan, Qin Liu, Kexin Yao, Shuang Liang, JiaFu Li, Mingfeng Yang, Danyan Xu, Gaohong Lin, Zhangying Wu, Haishan Shi, Min Zhang, Xiaolei Shi, Huanmin Liu, Yijie Zeng, Yunheng Chen, Yicheng Lin, Shuwei Zhang, Cong Ouyang, Shihan Tian, Yujing Gan, Mingyong Zeng, Jieqin Lv, Xiang Liang, Yuwang Cheng, Jianwen Guo, Pengcheng Ran, Yuping Ning, Huarong Zhou   +32 more
wiley   +1 more source

Proteotyping bacteria and fungi by phylopeptidomics: preanalytical factors review and potential

, 2023
International audienceHigh-throughput identification of microorganisms is key for clinical diagnostics and microbiology in general. Mass spectrometry for proteotyping microorganisms has been shown efficient because rapid and low cost. Recent studies have
Armengaud, Jean
core  

Recent advances in proteotyping pathogens and environmental microorganisms by tandem mass spectrometry

, 2022
International audienceQuestion. Tandem mass spectrometry-based proteotyping of microorganisms has key advantages over other approaches. Due to a greater number of signals recorded, the methodology allows the identification of microorganisms at highly ...
Chabas, Madisson, Jouffret, Virginie, Pible, Olivier, Culotta, Karen, Armengaud, Jean, Alpha-Bazin, Béatrice, Lozano, Clément, Grenga, Lucia, Hardouin, Pauline, Hayoun, Karim, Gouveia, Duarte   +10 more
core   +1 more source

Proteotyping of Streptococcus pneumoniae, using tandem mass spectrometry for identification of biomarkers for species and strain differentiation

, 2016
Background. Streptococcus pneumoniae (pneumococcus) is the leading cause of community-acquired pneumonia and a major cause of morbidity and mortality worldwide. S.
Jakobsson, Hedvig E, Gonzales-Siles, Lucia, Boulund, Fredrik,, Salvà-Serra, Francisco, Karlsson, Roger, Moore, Edward R.B.,, Kristiansson, Erik,   +6 more
core   +2 more sources

Table_1_Evaluation of Sample Preparation Methods for Fast Proteotyping of Microorganisms by Tandem Mass Spectrometry.XLSX

, 2019
Tandem mass spectrometry-based proteotyping allows characterizing microorganisms in terms of taxonomy and is becoming an important tool for investigating microbial diversity from several ecosystems.
Jean Armengaud (16857), Karim Hayoun (7350236), Olivier Pible (1696414), Béatrice Alpha-Bazin (7350239), Lucia Grenga (2158018), Duarte Gouveia (4574704)   +5 more
core   +1 more source

From satellites to peptides: Unraveling the microbial diversity of high-altitude Andean lakes by Tandem-Mass-Proteotyping

, 2023
Introduction: Out of up to one trillion microbial species, only 104 have been cultured (1), indicating that the vast majority of microbial taxa remain undiscovered.
Boy, Jens, Armengaud, Jean, Lozano, Clément, Boy, Diana, Leuko, Stefan, Runzheimer, Katharina, Moeller, Ralf   +6 more
core  

Additional file 1 of Comparison of intact protein and digested peptide techniques for high throughput proteotyping of ApoE

, 2022
Additional file 1: Table S1. Sciex 7500 source conditions. Table S2. Sciex 7500 parameters. Table S3. Exploris 480 parameters. Fig. S1. Box plots of the distribution of IS corrected peak areas derived from LC-MS/MS measurement of the ApoE peptides ...
Dragana Milosevic (8099285), Alicia Algeciras-Schimnich (14126955), Dan Figdore (14126952), Anthony Maus (8099282), Joshua Bornhorst (14126958)   +4 more
core   +1 more source