Results 71 to 80 of about 719 (174)
Development and validation of MethylCog, a blood DNA methylation proxy for cognition
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Heterogeneity in cognitive ability increases with age and predicts mild cognitive impairment (MCI) and dementia, but scalable blood‐based biomarkers are lacking. We developed and validated MethylCog, a parsimonious DNA methylation (DNAm) marker of general cognitive ability (g).
Deirdre M. O'Shea +9 more
wiley +1 more source
Usage and positivity rates of Alzheimer's disease biomarkers in a memory clinic
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Usage of biomarker tests for Alzheimer's disease pathology and rates of positivity were assessed at the Washington University Memory Diagnostic Center. METHODS Patients who underwent at least one biomarker test for clinical purposes between June 2021 and March 2025 were included (n = 1136). Data were retrospectively extracted from
Anna Hofmann +20 more
wiley +1 more source
Precision medicine for Alzheimer's disease in Down syndrome
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION Down syndrome (DS) exhibits a genetic form of Alzheimer's disease (AD). We used a blood‐based proteomic algorithm to predict cognitive status, treatment responders, and change to vitamin E in DS adults from a completed clinical trial, “Vitamin E in Aged Persons with Down Syndrome,” which originally showed no significant cognitive ...
Sonal Sukreet +6 more
wiley +1 more source
High Quality Catalog of Proteotypic Peptides from Human Heart [PDF]
Journal of Proteome Research, 2008 Proteomics research is beginning to expand beyond the more traditional shotgun analysis of protein mixtures to include targeted analyses of specific proteins using mass spectrometry. Integral to the development of a robust assay based on targeted mass spectrometry is prior knowledge of which peptides provide an accurate and sensitive proxy of the ...
Kelli G, Kline +4 more
openaire +2 more sources
Penalized Estimation in Finite Mixtures of Multivariate Regression Models via the EM‐PGM Algorithm
Statistics in Medicine, Volume 45, Issue 8-9, April 2026.ABSTRACT In many areas of medical and life sciences research, multiple diagnostic criteria and phenotypic outcomes are assessed simultaneously to characterize diseases and biological traits. These multivariate outcomes are often associated with high‐dimensional covariates and subject to underlying population heterogeneity, presenting challenges for ...
Heeyeon Kang, Sunyoung Shin
wiley +1 more source
Enzymatic dissociation induces transcriptional and proteotype bias in brain cell populations [PDF]
International Journal of Molecular Sciences, 2020 AbstractDifferent cell isolation techniques exist for transcriptomic and proteotype profiling of brain cells. Here, we provide a systematic investigation of the influence of different cell isolation protocols on transcriptional and proteotype profiles in mouse brain tissue by taking into account single-cell transcriptomics of brain cells, proteotypes ...
Daniele Mattei +12 more
openaire +6 more sources
Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases [PDF]
, 2023 BackgroundSmell impairment is one of the earliest features in Alzheimer's (AD) and Parkinson's diseases (PD). Due to sex differences exist in terms of smell and olfactory structures as well as in the prevalence and manifestation of both neurological ...
Cartas Cejudo, Paz +4 more
core +2 more sources
Sensitive and reproducible determination of clinical HDL proteotypes [PDF]
, 2020 AbstractBackgroundHigh-density lipoprotein (HDL) is a heterogenous mixture of blood-circulating multimolecular particles containing many different proteins, lipids, and RNAs. Recent advancements in mass spectrometry-based proteotype analysis strategies enable the sensitive and reproducible quantification of proteins across large patient cohorts ...
Sandra Goetze +9 more
openaire +1 more source
Early Cancer Detection: What's Going on and What's Next
MedComm, Volume 7, Issue 3, March 2026.Multicancer early detection (MCED) platforms have emerged as a promising strategy for the safe and effective early detection of multiple cancer types, with the potential to reduce metastatic burden and improve clinical outcomes, particularly for aggressive malignancies that lack effective population‐level screening.
Emma Di Carlo
wiley +1 more source
Classification of mouse B cell types using surfaceome proteotype maps [PDF]
Nature Communications, 2019 Abstract System-wide quantification of the cell surface proteotype and identification of extracellular glycosylation sites is challenging when samples are limited. Here, we miniaturize and automate the previously described Cell Surface Capture (CSC) technology, increasing sensitivity, reproducibility and throughput.
Marc van Oostrum +9 more
openaire +4 more sources