Results 41 to 50 of about 587 (160)

Direct Meta-Analyses Reveal Unexpected Microbial Life in the Highly Radioactive Water of an Operating Nuclear Reactor Core

Microorganisms, 2020
The pools of nuclear reactor facilities constitute harsh environments for life, bathed with ionizing radiation, filled with demineralized water and containing toxic radioactive elements.
Pauline C. M. Petit, Olivier Pible, Valérie Van Eesbeeck, Claude Alban, Gérard Steinmetz, Mohamed Mysara, Pieter Monsieurs, Jean Armengaud, Corinne Rivasseau   +8 more
doaj   +1 more source

Proteotypic classification of spontaneous and transgenic mammary neoplasms [PDF]

Breast Cancer Research, 2004
Abstract Introduction Mammary tumors in mice are categorized by using morphologic and architectural criteria. Immunolabeling for terminal differentiation markers was compared among a variety of mouse mammary neoplasms because expression of terminal differentiation markers, and especially of keratins ...
Mikaelian, I, Blades, N, Churchill, G A, Fancher, K, Knowles, B B, Eppig, J T, Sundberg, J P   +6 more
openaire   +2 more sources

Genotype-Proteotype Linkage in the Wiskott-Aldrich Syndrome [PDF]

The Journal of Immunology, 2005
Abstract Wiskott-Aldrich syndrome (WAS) is a platelet/immunodeficiency disease arising from mutations of WAS protein (WASP), a hemopoietic cytoskeletal protein. Clinical symptoms vary widely from mild (X-linked thrombocytopenia) to life threatening.
Maxim I, Lutskiy, Fred S, Rosen, Eileen, Remold-O'Donnell   +2 more
openaire   +2 more sources

Accuracy of an Automated Plasma Apolipoprotein E4 Proteotyping Immunoassay for Determination of APOE Genotype [PDF]

Alzheimers Dement
Abstract Background Anti‐amyloid therapies (AAT) for Alzheimer's disease are associated with the risk of amyloid‐related imaging abnormalities (ARIA). APOE4 homozygotes (E4/E4) have the highest risk, followed by APOE4 carriers (E4), making APOE genotyping essential for risk assessment.
Smith R, Alkhodair Y, Yadegari M, DeMarco M.   +3 more
europepmc   +2 more sources

Assessment and Prediction of Human Proteotypic Peptide Stability for Proteomics Quantification

Analytical Chemistry, 2023
Mass spectrometry coupled to liquid chromatography is one of the most powerful technologies for proteome quantification in biomedical samples. In peptide-centric workflows, protein mixtures are enzymatically digested to peptides prior their analysis.
Chiva, Cristina, Elhamraoui, Zahra, Solé, Amanda, Serret, Marc, Wilhelm, Mathias, Sabidó, Eduard   +5 more
openaire   +3 more sources

A Pangenome Approach for Discerning Species-Unique Gene Markers for Identifications of Streptococcus pneumoniae and Streptococcus pseudopneumoniae

Frontiers in Cellular and Infection Microbiology, 2020
Correct identifications of isolates and strains of the Mitis-Group of the genus Streptococcus are particularly difficult, due to high genetic similarity, resulting from horizontal gene transfer and homologous recombination, and unreliable phenotypic and ...
Lucia Gonzales-Siles, Lucia Gonzales-Siles, Lucia Gonzales-Siles, Roger Karlsson, Roger Karlsson, Roger Karlsson, Patrik Schmidt, Francisco Salvà-Serra, Francisco Salvà-Serra, Francisco Salvà-Serra, Francisco Salvà-Serra, Francisco Salvà-Serra, Daniel Jaén-Luchoro, Daniel Jaén-Luchoro, Susann Skovbjerg, Susann Skovbjerg, Susann Skovbjerg, Edward R. B. Moore, Edward R. B. Moore, Edward R. B. Moore, Edward R. B. Moore, Margarita Gomila   +21 more
doaj   +1 more source

Estimation of the allelic status of apolipoprotein E4 isoforms with fully automated LUMIPULSE® assays

Exploration of Neuroscience, 2023
Aim: Apolipoprotein E (ApoE) isoforms, especially the ApoE4 isoform, are genetic risk factors for Alzheimer’s disease (AD). Moreover, the APOE ε4 haplotype has a dose-dependent association with an increased risk of amyloid-related imaging abnormalities ...
Tatsushi Yuri, Rosina Degrieck, Dagmara Minczakiewicz, Hideo Sato, Jo Kamada, Takuya Nakazawa, Ina Vandenbroucke, Katsumi Aoyagi, Hisashi Nojima   +8 more
doaj   +1 more source

Breast Cancer Classification Based on Proteotypes Obtained by SWATH Mass Spectrometry

Cell Reports, 2019
Summary: Accurate classification of breast tumors is vital for patient management decisions and enables more precise cancer treatment. Here, we present a quantitative proteotyping approach based on sequential windowed acquisition of all theoretical ...
Pavel Bouchal, Olga T. Schubert, Jakub Faktor, Lenka Capkova, Hana Imrichova, Karolina Zoufalova, Vendula Paralova, Roman Hrstka, Yansheng Liu, Holger Alexander Ebhardt, Eva Budinska, Rudolf Nenutil, Ruedi Aebersold   +12 more
doaj   +1 more source

Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis

Frontiers in Microbiology, 2020
Like other RNA viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in host cells, continuously modulating the molecular environment.
Mercedes Lachén-Montes, Mercedes Lachén-Montes, Mercedes Lachén-Montes, Fernando J. Corrales, Fernando J. Corrales, Joaquín Fernández-Irigoyen, Joaquín Fernández-Irigoyen, Joaquín Fernández-Irigoyen, Enrique Santamaría, Enrique Santamaría, Enrique Santamaría   +10 more
doaj   +1 more source

Rapid and Culture Free Identification of Francisella in Hare Carcasses by High-Resolution Tandem Mass Spectrometry Proteotyping

Frontiers in Microbiology, 2020
Zoonotic pathogens that can be transmitted via food to humans have a high potential for large-scale emergencies, comprising severe effects on public health, critical infrastructures, and the economy. In this context, the development of laboratory methods
Natalie Witt, Natalie Witt, Sandro Andreotti, Anne Busch, Anne Busch, Kerstin Neubert, Knut Reinert, Herbert Tomaso, David Meierhofer   +8 more
doaj   +1 more source