Results 41 to 50 of about 507 (153)

A Pangenome Approach for Discerning Species-Unique Gene Markers for Identifications of Streptococcus pneumoniae and Streptococcus pseudopneumoniae

Frontiers in Cellular and Infection Microbiology, 2020
Correct identifications of isolates and strains of the Mitis-Group of the genus Streptococcus are particularly difficult, due to high genetic similarity, resulting from horizontal gene transfer and homologous recombination, and unreliable phenotypic and ...
Lucia Gonzales-Siles, Lucia Gonzales-Siles, Lucia Gonzales-Siles, Roger Karlsson, Roger Karlsson, Roger Karlsson, Patrik Schmidt, Francisco Salvà-Serra, Francisco Salvà-Serra, Francisco Salvà-Serra, Francisco Salvà-Serra, Francisco Salvà-Serra, Daniel Jaén-Luchoro, Daniel Jaén-Luchoro, Susann Skovbjerg, Susann Skovbjerg, Susann Skovbjerg, Edward R. B. Moore, Edward R. B. Moore, Edward R. B. Moore, Edward R. B. Moore, Margarita Gomila   +21 more
doaj   +1 more source

Estimation of the allelic status of apolipoprotein E4 isoforms with fully automated LUMIPULSE® assays

Exploration of Neuroscience, 2023
Aim: Apolipoprotein E (ApoE) isoforms, especially the ApoE4 isoform, are genetic risk factors for Alzheimer’s disease (AD). Moreover, the APOE ε4 haplotype has a dose-dependent association with an increased risk of amyloid-related imaging abnormalities ...
Tatsushi Yuri, Rosina Degrieck, Dagmara Minczakiewicz, Hideo Sato, Jo Kamada, Takuya Nakazawa, Ina Vandenbroucke, Katsumi Aoyagi, Hisashi Nojima   +8 more
doaj   +1 more source

Assessment and Prediction of Human Proteotypic Peptide Stability for Proteomics Quantification

Analytical Chemistry, 2023
Mass spectrometry coupled to liquid chromatography is one of the most powerful technologies for proteome quantification in biomedical samples. In peptide-centric workflows, protein mixtures are enzymatically digested to peptides prior their analysis.
Chiva, Cristina, Elhamraoui, Zahra, Solé, Amanda, Serret, Marc, Wilhelm, Mathias, Sabidó, Eduard   +5 more
openaire   +3 more sources

Breast Cancer Classification Based on Proteotypes Obtained by SWATH Mass Spectrometry

Cell Reports, 2019
Summary: Accurate classification of breast tumors is vital for patient management decisions and enables more precise cancer treatment. Here, we present a quantitative proteotyping approach based on sequential windowed acquisition of all theoretical ...
Pavel Bouchal, Olga T. Schubert, Jakub Faktor, Lenka Capkova, Hana Imrichova, Karolina Zoufalova, Vendula Paralova, Roman Hrstka, Yansheng Liu, Holger Alexander Ebhardt, Eva Budinska, Rudolf Nenutil, Ruedi Aebersold   +12 more
doaj   +1 more source

Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis

Frontiers in Microbiology, 2020
Like other RNA viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in host cells, continuously modulating the molecular environment.
Mercedes Lachén-Montes, Mercedes Lachén-Montes, Mercedes Lachén-Montes, Fernando J. Corrales, Fernando J. Corrales, Joaquín Fernández-Irigoyen, Joaquín Fernández-Irigoyen, Joaquín Fernández-Irigoyen, Enrique Santamaría, Enrique Santamaría, Enrique Santamaría   +10 more
doaj   +1 more source

Rapid and Culture Free Identification of Francisella in Hare Carcasses by High-Resolution Tandem Mass Spectrometry Proteotyping

Frontiers in Microbiology, 2020
Zoonotic pathogens that can be transmitted via food to humans have a high potential for large-scale emergencies, comprising severe effects on public health, critical infrastructures, and the economy. In this context, the development of laboratory methods
Natalie Witt, Natalie Witt, Sandro Andreotti, Anne Busch, Anne Busch, Kerstin Neubert, Knut Reinert, Herbert Tomaso, David Meierhofer   +8 more
doaj   +1 more source

Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma

npj Systems Biology and Applications, 2021
We proteotyped blood plasma from 30 mouse knockout strains and corresponding wild-type mice from the International Mouse Phenotyping Consortium. We used targeted proteomics with internal standards to quantify 375 proteins in 218 samples.
Yassene Mohammed, Sarah A. Michaud, Helena Pětrošová, Juncong Yang, Milan Ganguly, David Schibli, Ann M. Flenniken, Lauryl M. J. Nutter, Hibret A. Adissu, K. C. Kent Lloyd, Colin McKerlie, Christoph H. Borchers   +11 more
doaj   +1 more source

Sensitive and reproducible determination of clinical HDL proteotypes [PDF]

, 2020
Abstract Background High-density lipoprotein (HDL) is a heterogenous mixture of blood-circulating multimolecular particles containing many different proteins, lipids, and RNAs. Recent advancements in mass spectrometry-based proteotype analysis strategies enable the sensitive and reproducible ...
Sandra Goetze, Kathrin Frey, Lucia Rohrer, Silvija Radosavljevic, Jan Krützfeldt, Ulf Landmesser, Marco Bueter, Patrick G. A. Pedrioli, Arnold von Eckardstein, Bernd Wollscheid   +9 more
openaire   +1 more source

Reconstruction of protein networks from an atlas of maize seed proteotypes [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Here we report deep, quantitative, and replicated proteome analysis of a developing multicellular organism. We quantified protein abundance and levels of protein phosphorylation during development of the maize seed. The depth and quantitative nature of the data enabled a network-based approach to identify kinase-substrate ...
Walley, Justin W, Shen, Zhouxin, Sartor, Ryan, Wu, Kevin J, Osborn, Joshua, Smith, Laurie G, Briggs, Steven P   +6 more
openaire   +5 more sources

Prevalence of high‐risk plasma p‐tau217 levels and 5‐year transition of risk status in 70‐year‐olds

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION High‐risk plasma p‐tau217 levels predict amyloid‐β pathology in Alzheimer's disease, but little is known about the prevalence and temporal dynamics in the general population. METHODS Participants from the Gothenburg H70 Birth Cohort Study in Sweden were examined (n = 1157) and re‐examined after 5–7 years (n = 771).
Anna Dittrich, Burak Arslan, Tobias Skillbäck, Lina Rydén, Hlin Kvartsberg, Johan Gobom, Kaj Blennow, Henrik Zetterberg, Silke Kern, Ingmar Skoog   +9 more
wiley   +1 more source