A Robust and Universal Metaproteomics Workflow for Research Studies and Routine Diagnostics Within 24 h Using Phenol Extraction, FASP Digest, and the MetaProteomeAnalyzer [PDF]
, 2019 The investigation of microbial proteins by mass spectrometry (metaproteomics) is a key technology for simultaneously assessing the taxonomic composition and the functionality of microbial communities in medical, environmental, and biotechnological ...
Behne, A. +12 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 Correct identifications of isolates and strains of the Mitis-Group of the genus Streptococcus are particularly difficult, due to high genetic similarity, resulting from horizontal gene transfer and homologous recombination, and unreliable phenotypic and ...
Lucia Gonzales-Siles +21 more
doaj +1 more source
Exploration of Neuroscience, 2023 Aim: Apolipoprotein E (ApoE) isoforms, especially the ApoE4 isoform, are genetic risk factors for Alzheimer’s disease (AD). Moreover, the APOE ε4 haplotype has a dose-dependent association with an increased risk of amyloid-related imaging abnormalities ...
Tatsushi Yuri +8 more
doaj +1 more source
P4P: a peptidome-based strain-level genome comparison web tool [PDF]
, 2017 Peptidome similarity analysis enables researchers to gain insights into differential peptide profiles, providing a robust tool to discriminate strain-specific peptides, true intra-species differences among biological replicates or even microorganism ...
Blanco-Míguez, Aitor +3 more
core +1 more source
Rapid classification of clostridioides difficile strains using maldi-tof ms peak-based assay in comparison with pcr-ribotyping [PDF]
, 2021 Typing methods are needed for epidemiological tracking of new emerging and hyperviru-lent strains because of the growing incidence, severity and mortality of Clostridioides difficile infections (CDI).
Arcangeletti M. C. +8 more
core +1 more source
Genotype-Proteotype Linkage in the Wiskott-Aldrich Syndrome [PDF]
The Journal of Immunology, 2005 AbstractWiskott-Aldrich syndrome (WAS) is a platelet/immunodeficiency disease arising from mutations of WAS protein (WASP), a hemopoietic cytoskeletal protein. Clinical symptoms vary widely from mild (X-linked thrombocytopenia) to life threatening.
Maxim I, Lutskiy +2 more
openaire +2 more sources
Discovery of Species-unique Peptide Biomarkers of Bacterial Pathogens by Tandem Mass Spectrometry-based Proteotyping [PDF]
, 2020 Mass spectrometry (MS) and proteomics offer comprehensive characterization and identification of microorganisms and discovery of protein biomarkers that are applicable for diagnostics of infectious diseases.
Boulund, Fredrik +13 more
core +1 more source
Breast Cancer Classification Based on Proteotypes Obtained by SWATH Mass Spectrometry
Cell Reports, 2019 Summary: Accurate classification of breast tumors is vital for patient management decisions and enables more precise cancer treatment. Here, we present a quantitative proteotyping approach based on sequential windowed acquisition of all theoretical ...
Pavel Bouchal +12 more
doaj +1 more source
Mapping the dynamic high-density lipoprotein synapse [PDF]
, 2023 Background and aims Heterogeneous high-density lipoprotein (HDL) particles, which can contain hundreds of proteins, affect human health and disease through dynamic molecular interactions with cell surface proteins.
Frey, Kathrin +7 more
core +1 more source
Combination of MALDI-TOf mass spectrometry and machine learning for rapid antimicrobial resistance screening: the CASE of Campylobacter spp [PDF]
, 2022 While MALDI-TOF mass spectrometry (MS) is widely considered as the reference method for the rapid and inexpensive identification of microorganisms in routine laboratories, less attention has been addressed to its ability for detection of antimicrobial ...
Becker, S. L. +7 more
core +5 more sources