Results 41 to 50 of about 333 (136)

Assessment and Prediction of Human Proteotypic Peptide Stability for Proteomics Quantification

Analytical Chemistry, 2023
Mass spectrometry coupled to liquid chromatography is one of the most powerful technologies for proteome quantification in biomedical samples. In peptide-centric workflows, protein mixtures are enzymatically digested to peptides prior their analysis.
Chiva, Cristina, Elhamraoui, Zahra, Solé, Amanda, Serret, Marc, Wilhelm, Mathias, Sabidó, Eduard   +5 more
openaire   +3 more sources

Estimation of the allelic status of apolipoprotein E4 isoforms with fully automated LUMIPULSE® assays

Exploration of Neuroscience, 2023
Aim: Apolipoprotein E (ApoE) isoforms, especially the ApoE4 isoform, are genetic risk factors for Alzheimer’s disease (AD). Moreover, the APOE ε4 haplotype has a dose-dependent association with an increased risk of amyloid-related imaging abnormalities ...
Tatsushi Yuri, Rosina Degrieck, Dagmara Minczakiewicz, Hideo Sato, Jo Kamada, Takuya Nakazawa, Ina Vandenbroucke, Katsumi Aoyagi, Hisashi Nojima   +8 more
doaj   +1 more source

Breast Cancer Classification Based on Proteotypes Obtained by SWATH Mass Spectrometry

Cell Reports, 2019
Summary: Accurate classification of breast tumors is vital for patient management decisions and enables more precise cancer treatment. Here, we present a quantitative proteotyping approach based on sequential windowed acquisition of all theoretical ...
Pavel Bouchal, Olga T. Schubert, Jakub Faktor, Lenka Capkova, Hana Imrichova, Karolina Zoufalova, Vendula Paralova, Roman Hrstka, Yansheng Liu, Holger Alexander Ebhardt, Eva Budinska, Rudolf Nenutil, Ruedi Aebersold   +12 more
doaj   +1 more source

Proteomics Insights Into the Molecular Basis of SARS-CoV-2 Infection: What We Can Learn From the Human Olfactory Axis

Frontiers in Microbiology, 2020
Like other RNA viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in host cells, continuously modulating the molecular environment.
Mercedes Lachén-Montes, Mercedes Lachén-Montes, Mercedes Lachén-Montes, Fernando J. Corrales, Fernando J. Corrales, Joaquín Fernández-Irigoyen, Joaquín Fernández-Irigoyen, Joaquín Fernández-Irigoyen, Enrique Santamaría, Enrique Santamaría, Enrique Santamaría   +10 more
doaj   +1 more source

Rapid and Culture Free Identification of Francisella in Hare Carcasses by High-Resolution Tandem Mass Spectrometry Proteotyping

Frontiers in Microbiology, 2020
Zoonotic pathogens that can be transmitted via food to humans have a high potential for large-scale emergencies, comprising severe effects on public health, critical infrastructures, and the economy. In this context, the development of laboratory methods
Natalie Witt, Natalie Witt, Sandro Andreotti, Anne Busch, Anne Busch, Kerstin Neubert, Knut Reinert, Herbert Tomaso, David Meierhofer   +8 more
doaj   +1 more source

Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma

npj Systems Biology and Applications, 2021
We proteotyped blood plasma from 30 mouse knockout strains and corresponding wild-type mice from the International Mouse Phenotyping Consortium. We used targeted proteomics with internal standards to quantify 375 proteins in 218 samples.
Yassene Mohammed, Sarah A. Michaud, Helena Pětrošová, Juncong Yang, Milan Ganguly, David Schibli, Ann M. Flenniken, Lauryl M. J. Nutter, Hibret A. Adissu, K. C. Kent Lloyd, Colin McKerlie, Christoph H. Borchers   +11 more
doaj   +1 more source

Proteotyping bacteria: Characterization, differentiation and identification of pneumococcus and other species within the Mitis Group of the genus Streptococcus by tandem mass spectrometry proteomics.

PLoS ONE, 2018
A range of methodologies may be used for analyzing bacteria, depending on the purpose and the level of resolution needed. The capability for recognition of species distinctions within the complex spectrum of bacterial diversity is necessary for progress ...
Roger Karlsson, Lucia Gonzales-Siles, Margarita Gomila, Antonio Busquets, Francisco Salvà-Serra, Daniel Jaén-Luchoro, Hedvig E Jakobsson, Anders Karlsson, Fredrik Boulund, Erik Kristiansson, Edward R B Moore   +10 more
doaj   +1 more source

Reconstruction of protein networks from an atlas of maize seed proteotypes [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Here we report deep, quantitative, and replicated proteome analysis of a developing multicellular organism. We quantified protein abundance and levels of protein phosphorylation during development of the maize seed. The depth and quantitative nature of the data enabled a network-based approach to identify kinase-substrate
Walley, Justin W, Shen, Zhouxin, Sartor, Ryan, Wu, Kevin J, Osborn, Joshua, Smith, Laurie G, Briggs, Steven P   +6 more
openaire   +5 more sources

Meta‐Analysis: Redefining Liver Disease Risk in Heterozygous Alpha‐1 Antitrypsin Deficiency

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 4, Page 430-440, August 2026.
SERPINA1 MZ/SZ genotypes is a common but under‐recognised liver risk state. Despite modest shifts in liver function tests, it is associated with approximately doubled odds of fibrosis, cirrhosis, and liver transplantation, supporting its inclusion in chronic liver disease risk assessment.
Adam M. Syanda, Dimitra Georgantaki, Riona T. T. Linn, Amara Agbai, Hassan Tahir, Manako Sakai, Richard Thompson, Mariam Molokhia, S. Tamir Rashid   +8 more
wiley   +1 more source

Assigning statistical significance to proteotypic peptides via database searches [PDF]

Journal of Proteomics, 2011
Querying MS/MS spectra against a database containing only proteotypic peptides reduces data analysis time due to reduction of database size. Despite the speed advantage, this search strategy is challenged by issues of statistical significance and coverage.
Gelio, Alves, Aleksey Y, Ogurtsov, Yi-Kuo, Yu   +2 more
openaire   +2 more sources