Results 111 to 120 of about 123,279 (307)

Resolving a Complex Neonatal Phenotype by Rapid Trio Whole‐Genome Sequencing: A De Novo 11q14.3–q22.3 Deletion and a Splicing‐Altering Synonymous ANK1 Variant

Journal of Clinical Laboratory Analysis, EarlyView.
Clinical utility of trio WGS and time metrics in a neonate with congenital anomalies and hemolytic anemia. ABSTRACT Background Neonates with complex and evolving phenotypes often lack sufficiently specific clinical features to guide targeted genetic testing.
Hyun‐Woo Lee, Ja‐Hyun Jang, Beom Hee Lee, Hee‐Jeong Youk, Eun Sun Kim, Kee Hyun Cho, Yun Sil Chang, Heui Seung Jo, Mi‐Ae Jang   +8 more
wiley   +1 more source

Prothrombin conversion and thrombin decay in patients with cirrhosis—role of prothrombin and antithrombin deficiencies [PDF]

International audienceBackground: Thrombin generation (TG) in the presence of thrombomodulin (TG -TM) in the plasma of patients with cirrhosis (PWC) is tilted toward a hypercoagulable phenotype.
Lebreton, Aurelien, Sinegre, Thomas, Abergel, Armand, Lecompte, Thomas   +3 more
core   +1 more source

Preliminary Evaluation of a Novel Lupus Anticoagulant Activity Assay Unaffected by Anticoagulants

Journal of Clinical Laboratory Analysis, EarlyView.
A novel one‐step lupus anticoagulant (LA) assay based on the LA‐sensitivity ratio (LA‐SR) was developed to simplify diagnostic testing and reduce potential interference from anticoagulants. The LA‐SR method showed good agreement with guideline‐based LA testing (dRVVT and/or LA‐sensitive APTT) for the detection of LA and demonstrated limited influence ...
Ayu Hidaka, Risa Kaneshige, Seika Nakamura, Yukari Motoki, Junzo Nojima   +4 more
wiley   +1 more source

Venous thromboembolism, oral contraceptives and high prothrombin levels [PDF]

, 2003
TheG20210A prothrombin mutation, associated with elevated prothrombin levels, is a risk factor for venous thromboembolism (VTE) and displays a strong interaction with oral contraceptives (OC).
COSMI B, Valdre L., COCCHERI S, Cosmi B., BERNARDI, Francesco, VALDRE L, Coccheri S., LEGNANI C, Bernardi F., Palareti G., Legnani C., Boggian O., BOGGIAN O   +12 more
core   +1 more source

Inherited thrombophilia in a Han Chinese family caused by prothrombin Ile441Met mutation

Research and Practice in Thrombosis and Haemostasis
Background: Inherited thrombophilia (IT) is a genetically determined predisposition to thromboembolic events. Beyond the well-known G20210A mutation, there has been limited research on other prothrombin mutations in the Chinese population.
Si-Yuan Wen, Fei-Fei Chen, Ji-De Chen, Pan Tao, Chi Meng, Jing Huang, Xin Kang, Wei Chen, Chang-Qing Zhou   +8 more
doaj   +1 more source

Early prediction of multiple organ failure for sepsis patients based on machine learning algorithms

Journal of Intelligent Medicine, EarlyView.
Abstract In recent years, there has been a notable rise in sepsis incidence leading to more multiple organ failure and higher mortality. The lack of effective treatments for sepsis highlights the importance of early prediction in preventing multiple organ failure. This study aimed to develop a model for the early prediction of multiple organ failure in
Runnan He, Nan Su, Yuqing Wang, Yulin Sun, Xin Weng, Tania Pereira, Chenggong Hu, Keliang Xie, Meijun Pang, Kuo Zhang, Chuanxiang Huang, Xiuyun Liu   +11 more
wiley   +1 more source

The effect of prothrombin, the precursor of thrombin, on the proliferation and migration of colorectal cancer cells [PDF]

Archives of Biological Sciences
Thrombotic disorders are some of the main comorbidities in cancer patients. So far, research has indicated that thrombin, a key regulator of hemostasis, contributes to cancer progression.
Cumbo Marija, Dunjić-Manevski Sofija, Gvozdenov Maja, Mitić Martina Mia, Đorđević Valentina, Tomić Branko   +5 more
doaj   +1 more source

Early prediction of acute kidney injury in traumatic and non‐traumatic rhabdomyolysis using an interpretable machine learning model: A multicenter study with external validation

Journal of Intelligent Medicine, EarlyView.
Abstract Acute kidney injury (AKI) is a common and severe complication of rhabdomyolysis (RM), and early risk stratification remains challenging because of its multifactorial and heterogeneous nature. We developed and externally validated an interpretable machine learning (ML) model for early prediction of AKI in RM across traumatic and non‐traumatic ...
Chunli Liu, Jie Shi, Fengjuan Wang, Liang Ma, Huangang Hu, Li Zhang, Jie Song, Heng Jin, Dingwei Yang, Xiaoqin Guo, Haojun Fan, Qi Lv   +11 more
wiley   +1 more source

Prothrombin complex concentrates: an update. [PDF]

, 2010
Prothrombin complex concentrates: an ...
LIPPI, Giuseppe, Franchini M
core   +1 more source

A nonneutralizing antibody as cause of prothrombin deficiency in a patient with follicular lymphoma

Clinical Case Reports
Key Clinical Message Acquired inhibitors of blood coagulation are rare but of clinical importance. Prothrombin is a vitamin K‐dependent protein, and acquired antibodies toward prothrombin are often associated with the presence of lupus anticoagulant.
Cecilia Augustsson, Knut Taxbro, Karin Strandberg, Eva Zetterberg   +3 more
doaj   +1 more source