Results 101 to 110 of about 190,185 (400)
Clinical Pharmacology &Therapeutics, EarlyView.Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang +2 more
wiley +1 more source
, 2009 There is no accepted way of measuring prothrombin time without time loss for patients undergoing major surgery who are at risk of intraoperative dilution and consumption coagulopathy due to bleeding and volume replacement with crystalloids or colloids ...
Lord, Sarah J +7 more
core +1 more source
Clinical review: Prothrombin complex concentrates - evaluation of safety and thrombogenicity
Critical Care, 2011 Prothrombin complex concentrates (PCCs) are used mainly for emergency reversal of vitamin K antagonist therapy. Historically, the major drawback with PCCs has been the risk of thrombotic complications.
B. Sørensen +4 more
semanticscholar +1 more source
Prothrombin Time, an Indicator for Psoriasis Activity: A Case - Control Study
Iranian South Medical Journal, 2020 Background: Psoriasis is a common chronic and recurrent inflammatory skin disorder related to the immune system and characterized by the rapid growth of skin cells.
Majid Morovati-Sharifabad +2 more
doaj
Clinical Pharmacology &Therapeutics, EarlyView.Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu +6 more
wiley +1 more source
Polymorphisms in the Prothrombin Gene and their Association with Plasma Prothrombin Levels
, 2001 SummaryTo find genetic causes of high plasma prothrombin levels, an established prothrombotic risk factor, we searched for sequence variations in the prothrombin gene.
A. van Hylckama Vlieg +4 more
core +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Anorexia nervosa (AN) is a serious illness in which more than half of all deaths are due to malnutrition. Critically low energy and protein intake are known causes of massive weight loss, whereas micronutrient deficiencies due to a low‐calorie food pattern remain poorly characterized in children with AN. Micronutrient deficiencies in
Zenaida Iordan +6 more
wiley +1 more source
Partial activation of prothrombin and generation of prothrombin-R with cathepsin B
, 1960 Maximal yields of prothrombin-R were readily produced from a number of prothrombin derivatives when these were mixed with purified cathepsin B at pH 7.9.
Marion I. Barnhart
core +1 more source
Development of a paper-based lateral flow Prothrombin assay
, 2022 Disorders of haemostasis result in both excessive bleeding and clotting and are a major global cause of morbidity and mortality, particularly in the developing world. A small number of simple tests can be used to screen and monitor for such dysfunctions,
Killard, Anthony +4 more
core +1 more source