Results 121 to 130 of about 134,214 (298)

Prothrombin kringle-2 activates cultured rat brain microglia.

, 2002
Microglia, the major immune effector cells in the CNS, become activated when the brain suffers injury. In this study, we observed that prothrombin, a zymogen of thrombin, induced NO release and mRNA expression of inducible NO synthase, IL-1beta, and TNF ...
Pyo, H, Kim, SU, Kim, TH, Ryu, J, Kim, SS, Min, KJ, Rhim, TY, Jou, I, Joe, EH, Jin, B   +9 more
core   +1 more source

Prothrombin-Sepharose-Purified Factor V and Its Role in Prothrombin Conversion

, 2017
Bovine Factor V isolated by the method of Esnouf and Jobin (1967) has been further purified by affiniy chromotgraphy through prothrombin-sepharose. Factor V bound quantitative to the prothrombin-sepharose column.
T.C ONG, T.C, Ong
core   +1 more source

Factors Associated With Bilateral Involvement in Non‐Infectious Labyrinthitis: A Case–Control Study

The Laryngoscope, EarlyView.
Non‐infectious labyrinthitis may progress from unilateral to bilateral inner‐ear involvement, resulting in greater functional impairment. In this retrospective case–control study of 50 patients, younger age, female sex, and the presence of systemic disease were associated with bilateral involvement. These exploratory findings may help identify patients
Douglas Henderson, Blanca Amador Borrero, Aurélien Cadix, Karine Champion, Damien Sene, Philippe Herman, Charlotte Hautefort, Alain Londero, Michael Eliezer, Cassandre Djian   +9 more
wiley   +1 more source

An Analysis of Human Prothrombin by Starch Block Electrophoresis

, 1958
Prothrombin preparations, obtained from human ACD blood plasma and characterized by certain chemical, physical and biological measurement, were subjected to various types of electrophoretic analysis.
Gerard F. Lanchantin
core   +1 more source

Skeletal Muscle Mass Improvement and Survival After TIPS in Patients With Cirrhosis and Low Skeletal Muscle Index

Portal Hypertension &Cirrhosis, EarlyView.
Sarcopenia is common in patients with cirrhosis and contributes to poor prognosis. This study investigated whether transjugular intrahepatic portosystemic shunt (TIPS) is associated with improvement in skeletal muscle mass and whether such improvement translates into better transplant‐free survival in patients with cirrhosis and low skeletal muscle ...
Qinnian Li, Jiamin Xu, Chenrui Zhang, Rongfang Tu, Weimin Bao, Yingmei Tang   +5 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

The Relationship Between Blood Lipids, Coagulation Indexes, Blood Homocysteine and Sudden Deafness: A Retrospective Study and Mendelian Randomization Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Certain blood components, including blood lipids, coagulation parameters, and homocysteine, have been suggested to correlate with the incidence and prognosis of sudden sensorineural hearing loss (SSNHL). However, the nature of these associations remains controversial.
Feng‐Xin Yang, Yu‐Wan Song, Yan Wang, Kun Zhao, Hu‐Hui‐Fen He, Jing‐Jing Qiu, Da‐Wei Liu, Bo Li, Yan Sun   +8 more
wiley   +1 more source

Clinical case of cutaneous vasculopathy due to mutation of prothrombin gene F2(20210)GA

Vestnik Dermatologii i Venerologii
The article describes a case of skin vasculopathy due to systemic coagulopathy. In the setting of complete well-being, a 37-year-old female patient developed extensive areas of skin necrosis, predominantly in the lower extremities, over a period of 3 ...
Anastasiia D. Kovaleva, Maria V. Sokolova, Aleksandr V. Patrushev, Irena E. Belousova   +3 more
doaj   +1 more source

AUTOPROTHROMBIN C: A SECOND ENZYME FROM PROTHROMBIN

, 1962
In addition to thrombin, there is another derivative of prothrombin which is an end product of prothrombin activation. It is an accelerator of prothrombin activation, and is called autoprothrombin C. The activity develops from purified bovine prothrombin
Walter H. Seegers, Ewa Marciniak
core   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source