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Anaesthesia, 2020
Modern four‐factor prothrombin complex concentrate was designed originally for rapid targeted replacement of the coagulation factors II, VII, IX and X.
Gabor Erdoes +13 more
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Modern four‐factor prothrombin complex concentrate was designed originally for rapid targeted replacement of the coagulation factors II, VII, IX and X.
Gabor Erdoes +13 more
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THE ACETYLATION OF PROTHROMBIN
Canadian Journal of Biochemistry and Physiology, 1960Purified bovine prothrombin was acetylated to a range of 27 to 30% of its amino groups. Except for just significant amounts it lost its power to generate thrombin-C. Upon activation the yield of thrombin-E was 100% on the basis of the thrombin-C yield that was obtained on an aliquot sample of the prothrombin before acetylation.
Ricardo H. Landaburu, Walter H. Seegers
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American Journal of Physiology-Legacy Content, 1958
In experiments with purified biothrombin, it was found that strong solutions of sodium citrate or protamine sulfate (0.1% w/v) or purified platelet factor 3 depress the esterase activity and leave the clotting power unaltered. Apparently a depression of esterase activity is beneficial for the autocatalytic activation of purified prothrombin.
Walter H. Seegers, Ricardo H. Landaburu
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In experiments with purified biothrombin, it was found that strong solutions of sodium citrate or protamine sulfate (0.1% w/v) or purified platelet factor 3 depress the esterase activity and leave the clotting power unaltered. Apparently a depression of esterase activity is beneficial for the autocatalytic activation of purified prothrombin.
Walter H. Seegers, Ricardo H. Landaburu
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Pathophysiology of Haemostasis and Thrombosis, 1986
Using recombinant DNA techniques, DNA fragments coding for bovine prothrombin mRNA have been cloned and characterized. Structural studies have revealed that prothrombin mRNA encodes a precursor protein having an amino-terminal extension of 43 amino acid residues.
Ross T. A. MacGillivray, David M. Irwin
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Using recombinant DNA techniques, DNA fragments coding for bovine prothrombin mRNA have been cloned and characterized. Structural studies have revealed that prothrombin mRNA encodes a precursor protein having an amino-terminal extension of 43 amino acid residues.
Ross T. A. MacGillivray, David M. Irwin
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Critical Reviews in Eukaryotic Gene Expression, 1998
Prothrombin and thrombin are involved in diverse biological functions. The structure of prothrombin has been studied extensively and its cDNA has been cloned from several species. The tissue-specific expression of this protein has been studied, as well as the developmental expression pattern.
William Sun, Sandra J. Friezner Degen
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Prothrombin and thrombin are involved in diverse biological functions. The structure of prothrombin has been studied extensively and its cDNA has been cloned from several species. The tissue-specific expression of this protein has been studied, as well as the developmental expression pattern.
William Sun, Sandra J. Friezner Degen
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[Rinsho ketsueki] The Japanese journal of clinical hematology, 2021
Dysprothrombinemia is the rarest inherited bleeding disorder that is characterized by a decrease in the prothrombin activity, but normal antigen levels. In this study, we report the case of a compound heterozygote of two mutations in prothrombin; Met337Thr and Arg388His, which has previously been identified as "Prothrombin Himi." A systemic blood ...
Yusuke Kamihara +7 more
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Dysprothrombinemia is the rarest inherited bleeding disorder that is characterized by a decrease in the prothrombin activity, but normal antigen levels. In this study, we report the case of a compound heterozygote of two mutations in prothrombin; Met337Thr and Arg388His, which has previously been identified as "Prothrombin Himi." A systemic blood ...
Yusuke Kamihara +7 more
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Decarboxylation of bovine prothrombin fragment 1 and prothrombin [PDF]
Biochemistry, 1979 Bovine prothrombin fragment 1 and prothrombin undergo decarboxylation of their gamma-carboxyglutamic acid residues when the lyophilized proteins are heated in vacuo at 110 degrees C for several hours. The fully decarboxylated fragment 1 product has lost its barium-binding ability as well as the calcium-binding function which causes fluorescence ...
Kenneth G. Mann +2 more
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Prothrombin madrid : A new familial abnormality of prothrombin
Thrombosis Research, 1979Abstract An abnormal prothrombin has been detected in a 13 yr-old girl, with history of excessive bleeding. Prothrombin time and activated partial thromboplastin time were markedly prolonged. Prothrombin activity was very low when measured by biological assay using either physiological activators (3% by one stage assay and 20 US u/ml by two stage ...
A. Bezeaud +4 more
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Journal of the American Medical Association, 1947
To the Editor:— The recent current comment on Stability of Prothrombin inThe Journal, September 9, page 36, contains Certain statements to which I am compelled to take exception; particularly to one: "Unreliable values for prothrombin obtained by the one stage method etc." It might be well to inquire concerning the actual facts.
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To the Editor:— The recent current comment on Stability of Prothrombin inThe Journal, September 9, page 36, contains Certain statements to which I am compelled to take exception; particularly to one: "Unreliable values for prothrombin obtained by the one stage method etc." It might be well to inquire concerning the actual facts.
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Prothrombin Metz : Purification and Characterization of a Variant of Human Prothrombin [PDF]
Thrombosis and Haemostasis, 1979 For the purification of the abnormal prothrombin (Pt Metz), advantage has been taken of the existence in the family of three siblings who, being double heterozygotes for Pt Metz and a hypoprothrombinemia, have no normal Pt. Purification procedures included barium citrate adsorption and chromatography on DEAE Sephadex as for normal Pt.
J Elion, M Ribieto, D Labie, F Josso
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