Results 261 to 270 of about 153,345 (297)
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American Journal of Physiology-Legacy Content, 1956
In the activation of a prothrombin solution, only part of the prothrombin becomes biothrombin, some becomes autoprothrombin I and some becomes autoprothrombin II. Thrombin-thrombin is also obtained, and perhaps other derivatives of prothrombin are formed. Prothrombin thus has multiple potentialities and these can be developed in diverse ways.
J A, PENNER, W H, SEEGERS
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In the activation of a prothrombin solution, only part of the prothrombin becomes biothrombin, some becomes autoprothrombin I and some becomes autoprothrombin II. Thrombin-thrombin is also obtained, and perhaps other derivatives of prothrombin are formed. Prothrombin thus has multiple potentialities and these can be developed in diverse ways.
J A, PENNER, W H, SEEGERS
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Lupus, 2012
Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with ...
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Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with ...
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Prothrombin Segovia: A new congenital abnormality of prothrombin
Scandinavian Journal of Haematology, 1986A family with a new congenital dysprothrombinemia is presented. The propositus is a 21‐yr‐old man who presented simultaneously with hemartrosis of the left knee and an extensive hematoma following a minor trauma. Prothrombin time and activated partial thromboplastin time were prolonged.
P. R. Fisac +5 more
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Prothrombin Poissy: a new variant of human prothrombin
British Journal of Haematology, 1987SummaryA new congenital dysprothrombinaemia is described in a newborn baby girl who presented severe bleeding from the second day of life. Routine coagulation tests showed very prolonged prothrombin time and activated partial thromboplastin time with about 2% prothrombin activity in a one‐stage assay.
A. Bros +5 more
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Polymorphisms in the Prothrombin Gene and their Association with Plasma Prothrombin Levels [PDF]
Thrombosis and Haemostasis, 2001 SummaryTo find genetic causes of high plasma prothrombin levels, an established prothrombotic risk factor, we searched for sequence variations in the prothrombin gene. We selected subjects with the 20210-GG genotype (since the 20210-A allele is already known to be associated with high levels) and elevated prothrombin levels (≥ 130 U/dl) from the Leiden
F.R. Rosendaal +4 more
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Electroimmunoassay of prothrombin
Thrombosis Research, 1987Electroimmunoassay of normal (10-Gla) and Gla-deficient prothrombins containing 0 to 9 Gla (gamma-carboxyglutamyl) residues performed in EDTA against anti- (normal) prothrombin showed that each of the Gla-deficient proteins contained as much antigenic activity as does the normal molecule. In the presence of Ca2+, however, normal prothrombin appeared to
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Congenital Prothrombin Deficiency
Seminars in Thrombosis and Hemostasis, 2009Prothrombin deficiency is among the rarest inherited coagulation disorders, with a prevalence of approximately 1:2,000,000. Two main phenotypes can be distinguished: (1) hypoprothrombinemia (type I deficiency), characterized by concomitantly low levels of activity and antigen; and (2) dysprothrombinemia (type II deficiency), characterized by the normal
Lancellotti, Stefano +1 more
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British Journal of Haematology, 1983
Summary. A Cuban family with a new congenital dysprothrombinaemia is described. The propositus was a 5‐year‐old female who presented with umbilical bleeding after birth followed by easy bruising and bleeding tendency throughout her life. The main laboratory features of the defect included prolongation of prothrombin time and partial thromboplastin ...
Cruz A, R. Rubio, Corral Jf, Almagro D
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Summary. A Cuban family with a new congenital dysprothrombinaemia is described. The propositus was a 5‐year‐old female who presented with umbilical bleeding after birth followed by easy bruising and bleeding tendency throughout her life. The main laboratory features of the defect included prolongation of prothrombin time and partial thromboplastin ...
Cruz A, R. Rubio, Corral Jf, Almagro D
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Preparation of bovine prothrombin complex and purified prothrombin
Thrombosis Research, 1972Abstract A simplified procedure is described for the large-scale purification of bovine prothrombin complex. The protein was adsorbed on barium carbonate, eluted with 3.5% sodium citrate solution, and fractionated with ammonium sulfate. Additionally, prothrombin was separated from autoprothrombin III (Factor X) and further purified by DEAE-cellulose ...
Walter H. Seegers, Lowell E. McCoy
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Monoclonal antibodies to prothrombin
Thrombosis Research, 1987Hybridoma technology was used for the production of murine monoclonal antibodies to bovine normal prothrombin. Hybrid cell cultures were assayed for the production of antibodies, both in the absence and presence of calcium ions, by Enzyme-Linked Immunosorbent Assay (ELISA). Antibody-producing cell lines were cloned two times and grown as ascites tumors.
Oscar Sudilovsky, Om P. Malhotra
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