Results 71 to 80 of about 14,526,235 (284)

The risk of early mortality of polytrauma patients associated to ISS, NISS, APACHE II values and prothrombin time [PDF]

, 2013
BACKGROUND: The early hemodynamic normalization of polytrauma patients may lead to better survival outcomes. The aim of this study was to assess the diagnostic quality of trauma and physiological scores from widely used scoring systems in polytrauma ...
Otmar Trentz, Mica, Ladislav, Keel, Marius, Ladislav Mica, Marius Keel, Trentz, Otmar, Kaspar Rufibach, Rufibach, Kaspar   +7 more
core   +3 more sources

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with Surgeries

Canadian Journal of Gastroenterology and Hepatology, 2019
Background. Prothrombin time (PT) can predict survival in several types of malignancies. This study aims to investigate the predictive values of PT levels in patients with cholangiocarcinoma (CCA). Methods.
Hui-shan Wang, Xian-xiu Ge, Quan-peng Li, Jun-jie Nie, Lin Miao   +4 more
doaj   +1 more source

Lupus anticoagulant testing: Dilute prothrombin time (dPT)

, 2023
Lupus anticoagulants (LA) rarely affect routine prothrombin time assays because the high phospholipid (PL) content in thromboplastin reagents tends to overwhelm the antibodies.
Moore, G.
core   +1 more source

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Cryo-EM Structure of a Type I Anti-Prothrombin Antibody Reveals a Novel Kringle-1 Epitope and Its Functional Impact [PDF]

Structural Dynamics
Introduction.Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies (aPLs) that disrupt coagulation and increase thrombosis risk.
Suresh Kumar, Nicola Pozzi
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Nomogram for predicting bleeding events in nonvalvular atrial fibrillation patients receiving rivaroxaban: A retrospective study

Health Science Reports
Background and Aims To construct a bleeding events prediction model of nonvalvular atrial fibrillation (NVAF) patients receiving rivaroxaban. Methods We conducted a retrospective cohort study in patients with NVAF who received rivaroxaban from June 2017 ...
Chang Cao, Yijiao Xu, Weiwen Jiang, Shujing Wu, Yun Shen, Xiaotong Xia, Lumin Wang, Huijun Zhang, Hongni Jiang, Xiaoyu Li, Xiaoye Li, Yanrong Ye   +11 more
doaj   +1 more source

Evaluation of Coagulation Profile and Transfusion Support in Pre-eclampsia Patients: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Pre-eclampsia (PE) is an obstetric disorder characterised by high morbidity and mortality rates, yet it lacks a definitive etiology.
Sivaranjani Vijayasundaram, Kavitha Govindasamy, Anitha Thayanidhi, Arumugam Pothipillai   +3 more
doaj   +1 more source

Prothrombin and the One-stage Prothrombin Time [PDF]

BMJ, 1955
A J, QUICK, C V, HUSSEY
openaire   +2 more sources