Results 61 to 70 of about 20,673,795 (179)

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Proto-oncogene expression in peripheral blood mononuclear cells in IgA nephropathy [PDF]

, 1991
Proto-oncogene expression in peripheral blood mononuclear cells in IgA nephropathy. We have investigated the expression of proto-oncogenes in mononuclear cells obtained from patients with IgA nephropathy using a RNA hybridization technique. Patients with
Ebihara, Isao, Suzuki, Shigenobu, Tomino, Yasuhiko, Nakamura, Tsukasa, Koide, Hikaru   +4 more
core   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Müller Glia Subtypes Define Neuro‐Glial Associations and Spatial Morphogen Axes in the Zebrafish Retina

Glia, Volume 74, Issue 11, November 2026.
Zebrafish Müller glia are heterogeneous in the early larval retina. Zebrafish Müller glia subtypes define a spatial axis of retinoic acid metabolism. Neuron‐associated glial programs identified in Zebrafish Müller glia are evolutionarily conserved in mammals. ABSTRACT Müller glia are instrumental macroglia of the vertebrate retina, once thought to be a
Samuel S. Storey, Carrie L. Hehr, Shaelene Standing, Sarah McFarlane   +3 more
wiley   +1 more source

Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck [PDF]

, 2006
Background The proto-oncogene pituitary tumor-transforming gene (PTTG) has been shown to be abundantly overexpressed in a large variety of neoplasms likely promoting neo-vascularization and tumor invasiveness.
Solbach, Christine, Peters Silke, Eckerdt, Frank, Peters, Silke, Knecht, Rainald, Roller, Marc, Roller Marc, Eckerdt Frank, Solbach Christine, Knecht Rainald   +9 more
core   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, Volume 15, Issue 34, 11 September 2026.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Qianjinweijingtang Decoction and Its Granule Inhibit Respiratory Syncytial Virus Infection and the Associated Inflammatory Response

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The classical herbal formula Qianjinweijingtang in both decoction and granule forms, exhibits anti‐RSV activity. Isoliquiritigenin, quercetin, and gallic acid are identified as key active compounds. The mechanism involves interfering with viral entry and downregulating HIF‐1α and inflammatory responses, positioning the granule formulation as a ...
Chu‐Yi Liao, Mei‐Lan Yang, Ze‐Ping Chen, Bin Chen, Yu‐Jun Tang, Zhen Wang, Hui‐Nan Zhao, Su‐Hua Deng, Jin‐Hai Ye, Zhong Liu, Li‐Feng Chen, Man‐Mei Li   +11 more
wiley   +1 more source

A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product

, 1983
Organisms amenable to easy genetic analysis should prove helpful in assessing the function of at least those proto-oncogene products which are highly conserved in different eukaryotic cells.
Sander, C., Donath, C., Gallwitz, D.
core   +1 more source