Analyses of domains and domain fusions in human proto-oncogenes [PDF]
BMC Bioinformatics, 2009 Background Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers.
Wan Ping +5 more
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Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma [PDF]
Liver Research, 2021 Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.
Fang Wang, Peter Breslin S J, Wei Qiu
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Insertional Oncogenesis by Non-Acute Retroviruses: Implications for Gene Therapy [PDF]
Viruses, 2011 Retroviruses cause cancers in a variety of animals and humans. Research on retroviruses has provided important insights into mechanisms of oncogenesis in humans, including the discovery of viral oncogenes and cellular proto-oncogenes. The subject of this
Hung Fan, Chassidy Johnson
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Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. [PDF]
PLoS ONE, 2009 Epigenetic alterations have been implicated in the pathogenesis of solid tumors, however, proto-oncogenes activated by promoter demethylation have been sporadically reported.
Ian M Smith +16 more
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Proto-oncogenes in a eukaryotic unicellular organism play essential roles in plasmodial growth in host cells [PDF]
BMC Genomics, 2018 Background The eukaryotic unicellular protist Plasmodiophora brassicae is an endocellular parasite of cruciferous plants. In host cortical cells, this protist develops a unicellular structure that is termed the plasmodium.
Kai Bi +8 more
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The expression of tumour suppressors and proto-oncogenes in tissues susceptible to their hereditary cancers. [PDF]
Br J Cancer, 2015 BackgroundStudies of familial cancers have found that only a small subset of tissues are affected by inherited mutations in a given tumour suppressor gene (TSG) or proto-oncogene (POG), even though the mutation is present in all tissues.
Muir B, Nunney L.
europepmc +3 more sources
RNA-DNA differences are rarer in proto-oncogenes than in tumor suppressor genes. [PDF]
Sci Rep, 2012 It has long been assumed that DNA sequences and corresponding RNA transcripts are almost identical; a recent discovery, however, revealed widespread RNA-DNA differences (RDDs), which represent a largely unexplored aspect of human genome variation. It has
Gao F, Lin Y, Zhang RR.
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Germline Variants in Proto-Oncogenes and Tumor Suppressor Genes in Women with Cervical Cancer [PDF]
BiomedicinesBackground/Objectives: Cervical cancer (CC) remains a significant global health challenge, characterized by genetic heterogeneity and a complex molecular landscape, both of which contribute to its pathogenesis.
Ksenia Lenkova +6 more
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Dynamical Behaviour of a Time Delay Model of the ERK and STAT5 Interaction [PDF]
Bioautomation, 2007 In this paper we have done sensitive analysis of a time delay model which describes the ERK and STAT5 interaction. The results show that the type of the equilibrium point of the model can be a compound saddle-focus or a compound saddle-knot.
Kotev V.
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Genetic aspects of etiology and development of thyroid gland cancer [PDF]
Саратовский научно-медицинский журнал, 2012 Recent studies on thyroid gland cancer development and progression have identified new classes of tumor markers, proto-oncogenes, tumor-suppressing genes, cell receptor genes, identified genetic tumor-predisposing polymorphism and some other ...
Kovalenko Yu.V., Tolstokorov A.S.
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