Results 1 to 10 of about 5,394 (238)
Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
Liver Research, 2021 Hepatocellular carcinoma (HCC) is a very deadly disease. HCC initiation and progression involve multiple genetic events, including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor genes.
Fang Wang, Peter Breslin S J, Wei Qiu
doaj +1 more source
Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. [PDF]
PLoS ONE, 2009 Epigenetic alterations have been implicated in the pathogenesis of solid tumors, however, proto-oncogenes activated by promoter demethylation have been sporadically reported.
Ian M Smith +16 more
doaj +1 more source
Frontiers in Bioscience-Scholar, 2023 Background: Smoking is considered the single highest risk factor for lung cancer and has been suggested to be associated with accelerated somatic mutations in respiratory mucosa that lead to the development of lung cancer.
Amresh Kumar Mishra +2 more
doaj +1 more source
Characterization of Leukemia-Inducing Genes Using a Proto-Oncogene/Homeobox Gene Retroviral Human cDNA Library in a Mouse In Vivo Model. [PDF]
PLoS ONE, 2015 The purpose of this research is to develop a method to screen a large number of potential driver mutations of acute myeloid leukemia (AML) using a retroviral cDNA library and murine bone marrow transduction-transplantation system.
Su Hwa Jang, Sohyun Lee, Hee Yong Chung
doaj +1 more source
Anais Brasileiros de Dermatologia, 2014 Costello syndrome (CS) is a rare genetic disorder, first described by Costello in 1971, caused by mutations in the HRAS proto-oncogene. Clinical findings include facial dysmorphism, skin disorders, cognitive impairment, cardiac and musculoskeletal ...
Isy Lima Peixoto +5 more
doaj +1 more source
ProtoPred: Advancing Oncological Research Through Identification of Proto-Oncogene Proteins
IEEE Access, 2021 Proto-oncogenes are the genes that have the potential to transform normal cells into cancer cells as a result of mutations. They usually contain encoding of proteins whose function is to inhibit cell differentiation, stimulate cell division, and prevent ...
Sharaf J. Malebary +2 more
doaj +1 more source
Insertional Oncogenesis by Non-Acute Retroviruses: Implications for Gene Therapy
Viruses, 2011 Retroviruses cause cancers in a variety of animals and humans. Research on retroviruses has provided important insights into mechanisms of oncogenesis in humans, including the discovery of viral oncogenes and cellular proto-oncogenes. The subject of this
Hung Fan, Chassidy Johnson
doaj +1 more source
BMC Genomics, 2018 Background The eukaryotic unicellular protist Plasmodiophora brassicae is an endocellular parasite of cruciferous plants. In host cortical cells, this protist develops a unicellular structure that is termed the plasmodium.
Kai Bi +8 more
doaj +1 more source
Importância do vírus da leucemia felina na linfomagênese: Revisão
Pubvet, 2018 O vírus da Leucemia felina (FeLV) é um retrovírus oncogênico frequentemente relacionado ao linfoma em felinos domésticos. O principal mecanismo pelo qual o FeLV induz neoplasia é através da mutagênese insercional adquirida somaticamente, podendo o ...
Dayse Helena Lages da Silva +3 more
doaj +1 more source