Results 211 to 220 of about 5,394 (238)
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Proto-oncogenes and embryonic development
Biochimie, 1988The role of proto-oncogenes in embryonic development was investigated using one of the most characterized vertebrates, the amphibian Xenopus laevis. Genes which belong to the major proto-oncogene families have been detected in Xenopus genome. The developmental control of the myc gene was assayed using a characterized Xenopus myc probe and specific ...
Marcel Méchali +10 more
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Proto-oncogenes and cardiac development
Trends in Cardiovascular Medicine, 1992Proto-oncogene products participate in signaling processes that extend from the cell surface to the nucleus. Recent investigations have focused attention on the role that proto-oncogenes play in the proliferation, differentiation, and hypertrophic growth of cardiac myocytes.
N V, Matiuck, J L, Swain
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Proto-oncogenes in mammalian development
Current Biology, 1992The phenotypic analysis of mice carrying germline mutations in protooncogenes is beginning to provide convincing genetic evidence for the important role that these genes play in mammalian development and differentiation. Two approaches are being taken to elucidate the biological function of proto-oncogenes in vivo.
L M, Forrester, M, Brunkow, A, Bernstein
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Leukemia & Lymphoma, 1997
The mouse double minute 2 (mdm2) proto-oncogene was originally discovered as one of three genes that was amplified in a tumorigenic cell line derived from non-transformed Balb/c cells. Consistent with the expression pattern of mdm2 in these cells, it was later shown that the transforming potential of the mdm2 proto-oncogene can be activated by ...
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The mouse double minute 2 (mdm2) proto-oncogene was originally discovered as one of three genes that was amplified in a tumorigenic cell line derived from non-transformed Balb/c cells. Consistent with the expression pattern of mdm2 in these cells, it was later shown that the transforming potential of the mdm2 proto-oncogene can be activated by ...
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Proto-Oncogenes And Cardiac Hypertrophy
Annual Review of Physiology, 1989Generalized or focal myocardial hypenrophy is a component of most types of cardiac disease. Abnormalities of this growth process, which include in adequate, idiopathic, and pathological hypertrophy, have great clinical sig nificance. Postnatal heart enlargement is produced largely by increased size of striated muscle cells (hypertrophy) and increased
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1988
Retroviral oncogenes originally were derived from genes in eukaryotic cells. The seminal discovery that DNA sequences within normal, uninfected, nonmalignant cells were homologous to retroviral oncogenes was made in 1976. Cellular proto-oncogenes have exon and intron structures typical of eukaryotic genes.
Kathy B. Burck +2 more
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Retroviral oncogenes originally were derived from genes in eukaryotic cells. The seminal discovery that DNA sequences within normal, uninfected, nonmalignant cells were homologous to retroviral oncogenes was made in 1976. Cellular proto-oncogenes have exon and intron structures typical of eukaryotic genes.
Kathy B. Burck +2 more
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Proto‐oncogenes in cell differentiation
BioEssays, 1990AbstractProto‐oncogene products may be multi‐functional proteins with various roles in cell differentiation as well as cell proliferation. The molecular biology of the gene products of three well characterized proto‐oncogenes (c‐fos, c‐myc and c‐src) are described, and the roles of three other proto‐oncogene products, involved in hormone and growth ...
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Ciba Foundation symposium, 1990
Maturation promoting factor (MPF) is a cytoplasmic activity that causes oocytes arrested in prophase to resume meiosis. An inactive form of MPF termed pre-MPF exists in fully grown oocytes. In Xenopus oocytes, progesterone induces maturation and pre-MPF activation. These early maturation events require protein synthesis.
Vande, Woude +7 more
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Maturation promoting factor (MPF) is a cytoplasmic activity that causes oocytes arrested in prophase to resume meiosis. An inactive form of MPF termed pre-MPF exists in fully grown oocytes. In Xenopus oocytes, progesterone induces maturation and pre-MPF activation. These early maturation events require protein synthesis.
Vande, Woude +7 more
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Proto-Oncogenes and Human Cancers
New England Journal of Medicine, 1987The idea that specific genes or groups of genes are responsible for the induction or maintenance of cancer is by no means new. Recent research efforts to understand such genetic sequences have focused on the study of cellular oncogenes or proto-oncogenes.
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