Results 41 to 50 of about 57,684 (329)
Myb proteins inhibit fibroblast transformation by v-Rel
Molecular Cancer, 2006 Genes that cause cancer have been divided into two general classes – oncogenes that act in a dominant fashion to transform normal cells into a malignant state, and tumor suppressor genes that act in a dominant fashion to prevent such transformation.
Lipsick Joseph S +2 more
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Clofibrate treatment in pigs: Effects on parameters critical with respect to peroxisome proliferator-induced hepatocarcinogenesis in rodents [PDF]
, 2007 BACKGROUND: In rodents treatment with fibrates causes hepatocarcinogenesis, probably as a result of oxidative stress and an impaired balance between apoptosis and cell proliferation in the liver.
Eder, Klaus +4 more
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RET proto-oncogene and thyroid cancer [PDF]
Endocrine Pathology, 1997 The RET proto-oncogene has not only conclusively been identified as responsible for the three subtypes of the inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN-2) but also shown to be involved in the molecular evolution of sporadic medullary and papillary thyroid carcinoma as well as Hirschsprung's disease.
openaire +3 more sources
Proto‐oncogenes and oncogenes in epidermal neoplasia [PDF]
Experimental Dermatology, 1995 Abstract This review briefly will focus on the role of selected proto‐onco‐genes and their activated forms during the regulation of cell proliferation, cell death and tumor formation in the epidermis. In addition, the multiple and complex functions of these proteins in normal as well as transformed cells will be discussed.
G. Sliutz, M. M. Simon, T. A. Luger
openaire +3 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
DeepCBS: shedding light on the impact of mutations occurring at CTCF binding sites
Frontiers in GeneticsCTCF-mediated chromatin loops create insulated neighborhoods that constrain promoter-enhancer interactions, serving as a unit of gene regulation. Disruption of the CTCF binding sites (CBS) will lead to the destruction of insulated neighborhoods, which in
Yiheng Wang +5 more
doaj +1 more source
Nature Communications, 2016 miRNAs can function either as proto-oncogenes or tumour suppressors in several cancers; however their function in tumour initiating cells is unclear. Here, Zhang et al.
Wen Cai Zhang +21 more
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Characterization of a human cell line stably over-expressing the candidate oncogene, dual specificity phosphatase 12. [PDF]
PLoS ONE, 2011 Analysis of chromosomal rearrangements within primary tumors has been influential in the identification of novel oncogenes. Identification of the "driver" gene(s) within cancer-derived amplicons is, however, hampered by the fact that most amplicons ...
Erica L Cain +2 more
doaj +1 more source
Exploring the IL-21–STAT3 Axis as Therapeutic Target for Sézary Syndrome [PDF]
, 2014 Sézary syndrome is an aggressive cutaneous T-cell lymphoma. The malignant cells (Sézary cells) are present in skin, lymph nodes, and blood, and express constitutively activated signal transducer and activator of transcription (STAT)3.
Brenne +46 more
core +1 more source