Results 71 to 80 of about 226,605 (267)

Proto‐oncogenes and oncogenes in epidermal neoplasia [PDF]

Experimental Dermatology, 1995
Abstract This review briefly will focus on the role of selected proto‐onco‐genes and their activated forms during the regulation of cell proliferation, cell death and tumor formation in the epidermis. In addition, the multiple and complex functions of these proteins in normal as well as transformed cells will be discussed.
G. Sliutz, M. M. Simon, T. A. Luger
openaire   +3 more sources

Prospects for the use of statins in the treatment of neurofibromatosis type 1

Успехи молекулярной онкологии, 2022
Neurofibromatosis type 1 is caused by a germline mutation in the NF1 gene encoding the tumor suppressor neurofibromin. Deficiency of this protein causes hyperactivation of Ras proto-oncogenes. This leads to the development of tumors. Ras proteins undergo
R. N. Mustafin
doaj   +1 more source

The Proto-Oncogene ERG in Megakaryoblastic Leukemias [PDF]

Cancer Research, 2005
Abstract Aneuploidy is one of the hallmarks of cancer. Acquired additions of chromosome 21 are a common finding in leukemias, suggesting a contributory role to leukemogenesis. About 10% of patients with a germ line trisomy 21 (Down syndrome) are born with transient megakaryoblastic leukemia. We and others have shown acquired mutations in
Shai Izraeli, Sabine Strehl, Liat Rainis, Keren Machol, Keren Machol, Berthold Göttgens, Ester Rosenthal, Tsutomu Toki, John E. Pimanda, Etsuro Ito   +9 more
openaire   +3 more sources

G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas.

Cancer Research, 2007
Diffuse large B-cell lymphoma is the most common lymphoid malignancy in adults. It is a heterogeneous disease with variability in outcome. Genomic instability of a subset of proto-oncogenes, including c-MYC, BCL6, RhoH, PIM1, and PAX5, can contribute to ...
Michelle L Duquette, M. D. Huber, N. Maizels   +2 more
semanticscholar   +1 more source

Oncogenes in immune cells as potential therapeutic targets

ImmunoTargets and Therapy, 2018
Gulnur K Zakiryanova,1 Sarah Wheeler,2 Michael R Shurin2 1Department Biophysics and Biomedicine, Faculty Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan; 2Division of Clinical Immunopathology, Department of Pathology ...
Zakiryanova GK, Wheeler S, Shurin MR
doaj  

Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.

Cold Spring Harbor Symposia on Quantitative Biology, 2005
Networks of proto-oncogenes and tumor suppressors that control cancer cell proliferation also regulate stem cell self-renewal and possibly stem cell aging. Proto-oncogenes promote regenerative capacity by promoting stem cell function but must be balanced
Ricardo Pardal, A. Molofsky, Shenghui He, Sean J. Morrison, Sean J. Morrison   +4 more
semanticscholar   +1 more source

Role of Molecular Biology in Cancer Treatment: A Review Article

Iranian Journal of Public Health, 2017
Background: Cancer is a genetic disease and mainly arises due to a number of reasons include activation of oncogenes, malfunction of tumor suppressor genes or mutagenesis due to external factors. Methods: This article was written from the data collected
Aman IMRAN, Hafiza Yasara QAMAR, Qurban ALI, Hafsa NAEEM, Mariam RIAZ, Saima AMIN, Naila KANWAL, Fawad ALI, Muhammad Farooq SABAR, Idrees Ahmad NASIR   +9 more
doaj  

Ciclo celular: mecanismos reguladores e marcadores bioquímicos

Revista Brasileira de Cancerologia, 2023
Os mecanismos reguladores do ciclo celular e sua inter-relação com fatores de crescimento, oncogenes e anti-oncogenes têm se constituído nas áreas de maior avanço no estudo da biologia do câncer.
Silvia H. Rabenhorst, Roberto C. Burini, Fernando C. L. Schmitt   +2 more
doaj   +1 more source

The RET proto-oncogene in human cancers [PDF]

Oncogene, 2000
The activation of the RET proto-oncogene contributes to the development of human cancers in two different ways. Somatic rearrangements of RET with a variety of activating genes, which contribute to unscheduled expression and constitutive dimerization of the chimeric RET/PTC oncoproteins in thyroid follicular cells, are frequently found in radiation ...
openaire   +3 more sources

Functional Polymorphisms Associated with Disease-Free Survival in Resected Carcinoma of the Esophagus [PDF]

, 2010
Purpose: The aim of this study was to determine whether clinical outcome after surgical resection of esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) could be predicted by functional polymorphisms in different proto-oncogenes ...
A Ewart-Toland, A Nakamura, AK Walch, B Conne, BJ Boersma, C Mariette, C Mariette, DP Kelsen, DW Cescon, E Tanaka, FL Greene, G Manzoni de, GL Bond, H Saito, Hugo W. Tilanus, I Sturm, JB Hulscher, Jurjen J. Boonstra, KK Krishnadath, L Sobin, M Kaghad, Medical Research Council Oesophageal Cancer Working G, N Masuda, PC Wu, Ronald van Marion, RS Heist, SJ Fleishman, SM Lagarde, W Polkowski, Winand N. M. Dinjens, Y Shin   +30 more
core   +4 more sources