Concomitant Proton Pump Inhibitor Use and Survival in Urothelial Carcinoma Treated with Atezolizumab
Purpose: Emerging evidence indicates that gut microbiota dysbiosis can reduce the effectiveness of immune checkpoint inhibitors (ICI). Proton pump inhibitors (PPI) are known to induce gut microbiota changes.
A. Hopkins +4 more
semanticscholar +1 more source
ObjectivesThe purpose of this study was to reconfirm the association between the risk of fracture and proton pump inhibitor use and to establish evidence for defining a high-risk group of patients among proton pump inhibitor users.MethodsA nested case ...
Jong Joo Kim +3 more
doaj +1 more source
Proton Pump Inhibitors and Clopidogrel [PDF]
Proton pump inhibitors are often prescribed for patients on clopidogrel to prevent gastrointestinal bleeding complications. Recent data suggest higher rates of adverse cardiovascular events in patients on proton pump inhibitors and clopidogrel, in comparison to patients on clopidogrel only.
Michael A, Gaglia, Ron, Waksman
openaire +2 more sources
Clopidogrel and proton pump inhibitors [PDF]
In their comprehensive review of antithrombotic agents following acute coronary syndromes, Matteau and Bhatt[1][1] discuss the drug interaction between proton pump inhibitors and clopidogrel. They note that the COGENT trial, led by Bhatt, found no increased risk of major cardiovascular events at ...
openaire +5 more sources
Comparison of Proton Pump Inhibitor and Triple Therapy Regimen for Laryngospharyngeal Reflux Disease
Background: Laryngopharyngeal reflux is retrograde flow of contents of the stomach to the larynx and the pharynx. The study aims to compare two regimens (proton pump inhibitor monotherapy versus triple therapy) on the outcome of Helicobactor pylori ...
Apar Pokharel +2 more
doaj +1 more source
Proton pump inhibitors are associated with increased risk of development of chronic kidney disease [PDF]
Background Acute interstitial nephritis secondary to proton pump inhibitors (PPIs) frequently goes undiagnosed due to its subacute clinical presentation, which may later present as chronic kidney disease (CKD).
Arora, Pradeep +6 more
core +2 more sources
Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters [PDF]
OBJECTIVES: The secondary use of medical data contained in electronic medical records, such as hospital discharge letters, is a valuable resource for the improvement of clinical care (e.g. in terms of medication safety) or for research purposes. However,
Demuth, Ilja +4 more
core +1 more source
Iron deficiency anemia from iron malabsorption caused by proton pump inhibitors
Background Iron deficiency anemia without evidence for blood loss can present a diagnostic challenge. Proton pump inhibitors have been associated with iron deficiency anemia for many years, yet the relationship between the two until recently was not ...
Michael Boxer
doaj +1 more source
Proton Pump Inhibitors and CKD [PDF]
Proton pump inhibitors (PPIs) are taken by millions of people around the world, often for many months or even years, and some take PPIs on a permanent basis. PPIs, which are available both by prescription and over the counter, generally have an excellent overall safety profile.
Dennis G, Moledina, Mark A, Perazella
openaire +2 more sources
Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study [PDF]
Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication.
Beecher +41 more
core +1 more source

